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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

HOKE, J., J. BURKES, J. WHITE, and B. KLITZMAN. “EFFECTS OF HARD AND RESILIENT DENTURE MATERIALS ON TISSUE PERFUSION.” In Journal of Dental Research, 69:228–228. AMER ASSOC DENTAL RESEARCH, 1990.

Scholars@Duke

Smith, Y. R., B. Klitzman, M. N. Ellis, and F. C. Kull. “The effect of nicotinamide on microvascular density and thermal injury in rats.” J Surg Res 47, no. 5 (November 1989): 465–69. https://doi.org/10.1016/0022-4804(89)90103-0.

Full Text

Demas, C. P., R. Vann, E. Ritter, R. S. Sepka, B. Klitzman, and W. J. Barwick. “Decreased thrombogenicity of vascular prostheses following gas denucleation by hydrostatic pressure.” Plast Reconstr Surg 82, no. 6 (December 1988): 1042–45. https://doi.org/10.1097/00006534-198812000-00016.

Full Text

KLITZMAN, B., N. SCHRADER, and P. ELIZALDE. “INCREASES IN PERFUSED CAPILLARY DENSITY, CAPILLARY HEMATOCRIT AND SYSTEMIC HEMATOCRIT INDUCED BY CHRONIC EXPOSURE TO HYPOXIA OR COLD.” In Faseb Journal, 2:A1870–A1870. FEDERATION AMER SOC EXP BIOL, 1988.

Scholars@Duke

PERONA, B., M. CLINTON, and B. KLITZMAN. “INVIVO PLATELET-AGGREGATION IN THE MICROVASCULATURE FOLLOWING ULTRASONIC STIMULATION.” In Faseb Journal, 2:A1876–A1876. FEDERATION AMER SOC EXP BIOL, 1988.

Scholars@Duke

RITTER, E., R. VANN, R. SEPKA, and B. KLITZMAN. “REDUCTION IN THROMBOGENICITY OF MICROVASCULAR PROSTHESES.” Faseb Journal. FEDERATION AMER SOC EXP BIOL, March 25, 1988.

Scholars@Duke

Forley, B. G., L. Huang, J. Bartolome, D. Serafin, and B. Klitzman. “The potential role of polyamine inhibition in keloid therapy.” Surgical Forum, January 1, 1988.

Scholars@Duke

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