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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Dewhirst, M. W., E. T. Ong, B. Klitzman, T. W. Secomb, R. Z. Vinuya, R. Dodge, D. Brizel, and J. F. Gross. “Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.” Radiat Res 130, no. 2 (May 1992): 171–82.

Scholars@Duke

SECOMB, T. W., R. HSU, M. W. DEWHIRST, B. KLITZMAN, and J. F. GROSS. “SIMULATION OF OXYGEN-TRANSPORT TO TUMOR-TISSUE BY MICROVASCULAR NETWORKS.” In Faseb Journal, 6:A2084–A2084. FEDERATION AMER SOC EXP BIOL, 1992.

Scholars@Duke

Bensen, C. V., R. D. Vann, K. E. Koger, and B. Klitzman. “Quantification of gas denucleation and thrombogenicity of vascular grafts.” J Biomed Mater Res 25, no. 3 (March 1991): 373–86. https://doi.org/10.1002/jbm.820250309.

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Clinton, M. S., R. S. Sepka, D. Bristol, W. C. Pederson, W. J. Barwick, D. Serafin, and B. Klitzman. “Establishment of normal ranges of laser Doppler blood flow in autologous tissue transplants.” Plast Reconstr Surg 87, no. 2 (February 1991): 299–309. https://doi.org/10.1097/00006534-199102000-00012.

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Goldberg, M., D. Serafin, and B. Klitzman. “Quantification of neutrophil adhesion to skeletal muscle venules following ischemia-reperfusion.” J Reconstr Microsurg 6, no. 3 (July 1990): 267–70. https://doi.org/10.1055/s-2007-1006829.

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Goldberg, J., R. S. Sepka, B. P. Perona, W. C. Pederson, and B. Klitzman. “Laser Doppler blood flow measurements of common cutaneous donor sites for reconstructive surgery.” Plast Reconstr Surg 85, no. 4 (April 1990): 581–86. https://doi.org/10.1097/00006534-199004000-00013.

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Eshbaugh, W. G., B. G. Forley, E. F. Ritter, D. Serafin, and B. Klitzman. “Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine.” Plast Reconstr Surg 85, no. 4 (April 1990): 593–96. https://doi.org/10.1097/00006534-199004000-00015.

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