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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Vann, R. D., E. F. Ritter, M. D. Plunkett, C. W. Wyble, C. V. Bensen, W. A. Gerth, W. J. Barwick, and B. Klitzman. “Patency and blood flow in gas denucleated arterial prostheses.” J Biomed Mater Res 27, no. 4 (April 1993): 493–98. https://doi.org/10.1002/jbm.820270410.

Full Text

SONNY, M., A. D. SAM, C. A. PIANTADOSI, and B. KLITZMAN. “EFFECTS OF HYPERBARIC-OXYGEN ON ARTERIOLAR DIAMETER IN RAT CREMASTER MUSCLE.” In Faseb Journal, 7:A557–A557. FEDERATION AMER SOC EXP BIOL, 1993.

Scholars@Duke

SAM, A. D., M. SONNY, C. A. PIANTADOSI, and B. KLITZMAN. “EFFECT OF HYPERBARIC-OXYGEN ON MUSCLE OXYGEN-TENSIONS.” In Faseb Journal, 7:A449–A449. FEDERATION AMER SOC EXP BIOL, 1993.

Scholars@Duke

WIGOD, M., and B. KLITZMAN. “INCREASED MICROVASCULAR ENDOTHELIAL-CELL ADHESION TO BIOMATERIALS.” In Faseb Journal, 7:A241–A241. FEDERATION AMER SOC EXP BIOL, 1993.

Scholars@Duke

Secomb, T. W., R. Hsu, M. W. Dewhirst, B. Klitzman, and J. F. Gross. “Analysis of oxygen transport to tumor tissue by microvascular networks.” Int J Radiat Oncol Biol Phys 25, no. 3 (February 15, 1993): 481–89. https://doi.org/10.1016/0360-3016(93)90070-c.

Full Text

Brizel, D. M., B. Klitzman, J. M. Cook, J. Edwards, G. Rosner, and M. W. Dewhirst. “A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model.” Int J Radiat Oncol Biol Phys 25, no. 2 (January 15, 1993): 269–76. https://doi.org/10.1016/0360-3016(93)90348-y.

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Dewhirst, M. W., D. Madwed, R. E. Meyer, E. T. Ong, B. Klitzman, G. L. Rosner, and R. Dodge. “Reduction in tumor blood flow in skin flap tumor after hydralazine is not due to a vascular steal phenomenon.” Radiation Oncology Investigations 1, no. 5 (January 1, 1993): 270–78. https://doi.org/10.1002/roi.2970010504.

Full Text

Dewhirst, M. W., E. T. Ong, D. Madwed, B. Klitzman, T. Secomb, D. Brizel, J. Bonaventura, G. Rosner, B. Kavanagh, and J. Edwards. “Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature.” Radiat Res 132, no. 1 (October 1992): 61–68.

Scholars@Duke

Wu, N. Z., B. Klitzman, R. Dodge, and M. W. Dewhirst. “Diminished leukocyte-endothelium interaction in tumor microvessels.” Cancer Res 52, no. 15 (August 1, 1992): 4265–68.

Scholars@Duke

Dewhirst, M. W., R. Z. Vinuya, E. T. Ong, B. Klitzman, G. Rosner, T. W. Secomb, and J. F. Gross. “Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature.” Radiat Res 130, no. 3 (June 1992): 345–54.

Scholars@Duke

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