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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

SONNTAG, K., E. J. BURKES, J. HOKE, and B. KLITZMAN. “PULPAL RESPONSE TO CAVITY PREPARATION WITH THE ERYAG LASER.” Journal of Dental Research. AMER ASSOC DENTAL RESEARCH, January 1, 1995.

Scholars@Duke

Hoke, J. A., E. J. Burkes, J. T. White, M. B. Duffy, and B. Klitzman. “Blood-flow mapping of oral tissues by laser Doppler flowmetry.” Int J Oral Maxillofac Surg 23, no. 5 (October 1994): 312–15. https://doi.org/10.1016/s0901-5027(05)80117-1.

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Kim, Y. B., H. P. Reisch, D. Serafin, and B. Klitzman. “Evaluation of the thrombogenecity of microvascular prosthesis by in vivo microscopy.” J Korean Med Sci 9, no. 5 (October 1994): 357–61. https://doi.org/10.3346/jkms.1994.9.5.357.

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Wu, N. Z., B. A. Ross, C. Gulledge, B. Klitzman, R. Dodge, and M. W. Dewhirst. “Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation.” Br J Cancer 69, no. 5 (May 1994): 883–89. https://doi.org/10.1038/bjc.1994.171.

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KLITZMAN, B., N. SCHRADER, R. E. MCLENDON, and M. W. DEWHIRST. “QUANTITATIVE MORPHOLOGY OF RAT CARCINOMA WITH RELEVANCE TO OXYGENATION.” In Faseb Journal, 8:A1046–A1046. FEDERATION AMER SOC EXP BIOL, 1994.

Scholars@Duke

Peterseim, D. S., C. H. Meyers, D. M. Craig, J. S. Heinle, A. M. Jayawant, J. J. Devaney, B. M. Klitzman, and P. Van Trigt. “Enhanced cardiac preservation with oxygenated University of Wisconsin solution.” J Surg Res 55, no. 6 (December 1993): 588–94. https://doi.org/10.1006/jsre.1993.1189.

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Wu, N. Z., B. Klitzman, G. Rosner, D. Needham, and M. W. Dewhirst. “Measurement of material extravasation in microvascular networks using fluorescence video-microscopy.” Microvasc Res 46, no. 2 (September 1993): 231–53. https://doi.org/10.1006/mvre.1993.1049.

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