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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Sharkawy, A. A., B. Klitzman, G. A. Truskey, and W. M. Reichert. “Diffusion properties of capsular tissue.” Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction With the International Biomaterials Symposium, December 1, 1996.

Scholars@Duke

Laney, T. V. du, G. A. Truskey, and B. Klitzman. “Fibronectin enhances cell spreading and retention on ePTFE under shear in vitro.” Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction With the International Biomaterials Symposium, December 1, 1996.

Scholars@Duke

Sonntag, K. D., B. Klitzman, E. J. Burkes, J. Hoke, and J. Moshonov. “Pulpal response to cavity preparation with the Er:YAG and Mark III free electron lasers.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81, no. 6 (June 1996): 695–702. https://doi.org/10.1016/s1079-2104(96)80076-x.

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Ritter, E. F., J. P. Anthony, L. S. Levin, C. P. Demas, B. Klitzman, D. Skarada, and D. Serafin. “Microsurgical composite tissue transplantation at difficult recipient sites facilitated by preliminary installation of vein grafts as arteriovenous loops.” J Reconstr Microsurg 12, no. 4 (May 1996): 231–40. https://doi.org/10.1055/s-2007-1006482.

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Zavitsanos, G., L. Huang, W. Panza, D. Serafin, and B. Klitzman. “Limiting impairment of muscle function following ischemia and reperfusion in rabbits.” J Reconstr Microsurg 12, no. 3 (April 1996): 183–87. https://doi.org/10.1055/s-2007-1006474.

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Zhang, J., A. D. Sam, B. Klitzman, and C. A. Piantadosi. “Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen.” Undersea Hyperb Med 22, no. 4 (December 1995): 377–82.

Scholars@Duke

Kimura, H., N. Z. Wu, R. Dodge, D. P. Spencer, B. M. Klitzman, T. M. McIntyre, and M. W. Dewhirst. “Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021.” Int J Radiat Oncol Biol Phys 33, no. 3 (October 15, 1995): 627–33. https://doi.org/10.1016/0360-3016(95)00205-D.

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Skarada, D. J., G. R. Erickson, K. L. Warnecke, T. V. du Laney, C. S. Greenberg, E. F. Ritter, and B. Klitzman. “Assessments of thrombogenicity by three in vitro techniques. Student Research Award in the Undergraduate, Master Candidate, or Health Science Degree Candidate Category, 21st annual meeting of the Society for Biomaterials, San Francisco, CA, March 18-22, 1995.” J Biomed Mater Res 29, no. 9 (September 1995): 1039–45. https://doi.org/10.1002/jbm.820290903.

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HUSSEIN, M., S. ABDELALEEM, M. ELFALAKY, D. SERAFIN, and B. KLITZMAN. “CORRELATION BETWEEN SKELETAL-MUSCLE HIGH-ENERGY ADENINE-NUCLEOTIDE CONTENT AND APPLIED PRESSURE.” In Faseb Journal, 9:A693–A693. FEDERATION AMER SOC EXP BIOL, 1995.

Scholars@Duke

Zhang, J., H. Benveniste, B. Klitzman, and C. A. Piantadosi. “Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.” Stroke 26, no. 2 (February 1995): 298–304. https://doi.org/10.1161/01.str.26.2.298.

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