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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Bhat, V. D., B. Klitzman, K. Koger, G. A. Truskey, and W. M. Reichert. “Improving endothelial cell adhesion to vascular graft surfaces: clinical need and strategies.” J Biomater Sci Polym Ed 9, no. 11 (1998): 1117–35. https://doi.org/10.1163/156856298x00686.

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Wisniewski, N., B. Klitzman, and W. M. Reichert. “Membrane biofouling measured by microdialysis.” Proceedings of the Controlled Release Society, January 1, 1998.

Scholars@Duke

Sharkawy, A. A., B. Klitzman, G. A. Truskey, and W. M. Reichert. “Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties.” J Biomed Mater Res 37, no. 3 (December 5, 1997): 401–12. https://doi.org/10.1002/(sici)1097-4636(19971205)37:3<401::aid-jbm11>3.0.co;2-e.

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Ritter, E. F., Y. B. Kim, H. P. Reischl, D. Serafin, A. M. Rudner, and B. Klitzman. “Heparin coating of vascular prostheses reduces thromboemboli.” Surgery 122, no. 5 (November 1997): 888–92. https://doi.org/10.1016/s0039-6060(97)90329-9.

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Musselwhite, J. M., B. Klitzman, W. Maixner, and E. J. Burkes. “Laser Doppler flowmetry: a clinical test of pulpal vitality.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84, no. 4 (October 1997): 411–19. https://doi.org/10.1016/s1079-2104(97)90041-x.

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Ritter, E. F., M. Axelrod, K. W. Minn, E. Eades, A. M. Rudner, D. Serafin, and B. Klitzman. “Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol.” Plast Reconstr Surg 100, no. 4 (September 1997): 973–80. https://doi.org/10.1097/00006534-199709001-00021.

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Viscardi, P. J., E. A. Page, H. G. Clark, D. Serafin, and B. Klitzman. “Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene.” J Reconstr Microsurg 13, no. 4 (May 1997): 303–6. https://doi.org/10.1055/s-2007-1000240.

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Sharkawy, A., B. Klitzman, G. Truskey, and W. Reichert. “Diffusion properties of tissue which encapsulates subcutaneous implants.” Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering, January 1, 1997.

Scholars@Duke

Skarada, D. J., T. V. du Laney, T. M. Steele, E. F. Ritter, and B. Klitzman. “Continual in vivo assessment of 1 mm diameter vascular prostheses.” Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction With the International Biomaterials Symposium, December 1, 1996.

Scholars@Duke

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