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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Erdmann, Detlev, Ranya Sweis, Michael S. Wong, Laura E. Niklason, Tracey V. du Laney, L Scott Levin, Bruce Klitzman, and Kevin C. Olbrich. “Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury.” Plast Reconstr Surg 111, no. 2 (February 2003): 775–80. https://doi.org/10.1097/01.PRS.0000041534.99907.75.

Full Text

Stenken, Julie A., William M. Reichert, and Bruce Klitzman. “Magnetic resonance imaging of a tissue/implanted device biointerface using in vivo microdialysis sampling.” Anal Chem 74, no. 18 (September 15, 2002): 4849–54. https://doi.org/10.1021/ac020234w.

Full Text

Wisniewski, N., B. Klitzman, B. Miller, and W. M. Reichert. “Decreased analyte transport through implanted membranes: differentiation of biofouling from tissue effects.” J Biomed Mater Res 57, no. 4 (December 15, 2001): 513–21. https://doi.org/10.1002/1097-4636(20011215)57:4<513::aid-jbm1197>3.0.co;2-e.

Full Text

Ettinger, S. N., C. C. Poellmann, N. A. Wisniewski, A. A. Gaskin, J. S. Shoemaker, J. M. Poulson, M. W. Dewhirst, and B. Klitzman. “Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis.” Cancer Res 61, no. 21 (November 1, 2001): 7964–70.

Scholars@Duke

Duncan, G. T., A. C. Lockhart, J. R. Ross, B. Klitzman, K. Olbrich, V. M. Lee, A. D. Proia, and H. I. Hurwitz. “Wound angiogenesis in healthy volunteers using OPSI technology: A potential surrogate marker for antiangiogenesis agents.” Clinical Cancer Research. AMER ASSOC CANCER RESEARCH, November 1, 2001.

Scholars@Duke

Ravin, A. G., K. C. Olbrich, L. S. Levin, A. L. Usala, and B. Klitzman. “Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats.” J Biomed Mater Res 58, no. 3 (May 1, 2001): 313–18. https://doi.org/10.1002/1097-4636(2001)58:3<313::aid-jbm1023>3.0.co;2-o.

Full Text

Klitzman, B., R. N. Sweis, and K. C. Olbrich. “Chronic percutaneous intravital microscopy using orthogonal polarization spectral imaging.” In Faseb Journal, 15:A53–A53. FEDERATION AMER SOC EXP BIOL, 2001.

Scholars@Duke

Wisniewski, N., N. Rajamand, W. Reichert, B. Klitzman, and U. Ungerstedt. “Metabolites at a biomaterial-tissue interface sampled by microdialysis - a comparison of the subcutaneous foreign body response in humans and rats over 8 days.” Annals of Biomedical Engineering, December 1, 2000.

Scholars@Duke

Dewhirst, M. W., B. Klitzman, R. D. Braun, D. M. Brizel, Z. A. Haroon, and T. W. Secomb. “Review of methods used to study oxygen transport at the microcirculatory level.” Int J Cancer 90, no. 5 (October 20, 2000): 237–55.

Scholars@Duke

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