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Bruce Klitzman, PhD

Associate Professor of Surgery
Assistant Research Professor in Cell Biology
Associate Professor of Biomedical Engineering
Office: 479 & 489 Med Sci Res Bl 1, 203 Research Dr, 203 Research Dr, Durham, NC 27710
Campus Mail: DUMC Box 3906 Med Ctr, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Kanick, Stephen C., Peter A. Schneider, Bruce Klitzman, Natalie A. Wisniewski, and Kerstin Rebrin. “Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers.” Microvasc Res 124 (July 2019): 6–18. https://doi.org/10.1016/j.mvr.2019.02.002.

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Scheuermann, Uwe, Mohamed M. Ibrahim, John Yerxa, William Parker, Matthew G. Hartwig, Bruce Klitzman, and Andrew S. Barbas. “Machine Perfusion of Liver Grafts With Implantable Oxygen Biosensors: Proof of Concept Study in a Rodent Model.” Transplant Direct 5, no. 7 (July 2019): e463. https://doi.org/10.1097/TXD.0000000000000905.

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Patel, Preet, Mahmoud Ibrahim, Ryan Schweller, Bruce Klitzman, and Mohamid Ibrahim. “NOVEL IMPLANTABLE BIOSENSORS FOR LIFETIME-BASED MONITORING OF OXYGENATION TO PREDICT WOUND HEALING.” In Wound Repair and Regeneration, 27:A19–A19. WILEY, 2019.

Scholars@Duke

Wang, H. N., J. K. Register, A. M. Fales, N. Gandra, P. Strobbia, E. H. Cho, A. Boico, G. M. Palmer, B. Klitzman, and T. Vo-Dinh. “Implantable "smart tattoo" SERS nanosensors for in vivo detection of nucleic acid biotargets in a large animal model.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10894, 2019. https://doi.org/10.1117/12.2514634.

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Wang, H. N., J. K. Register, A. M. Fales, N. Gandra, E. H. Cho, A. Boico, G. M. Palmer, B. Klitzman, and T. Vo-Dinh. “Surface-enhanced Raman scattering nanosensors for in vivo detection of nucleic acid targets in a large animal model.” Nano Research 11, no. 8 (August 1, 2018): 4005–16. https://doi.org/10.1007/s12274-018-1982-3.

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Blueschke, Gert, Alina Boico, Ayele H. Negussie, Pavel Yarmolenko, Bradford J. Wood, Ivan Spasojevic, Ping Fan, et al. “Enhanced Drug Delivery to the Skin Using Liposomes.” Plast Reconstr Surg Glob Open 6, no. 7 (July 2018): e1739. https://doi.org/10.1097/GOX.0000000000001739.

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Reese, Aspen T., Eugenia H. Cho, Bruce Klitzman, Scott P. Nichols, Natalie A. Wisniewski, Max M. Villa, Heather K. Durand, et al. “Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.” Elife 7 (June 19, 2018). https://doi.org/10.7554/eLife.35987.

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Ibrahim, Mohamed M., Jennifer S. Chien, Mahmoud M. Mohammed, Timothy King, and Bruce Klitzman. “Detection of Acute Vascular Occlusion Using Oxygen Monitoring in Myocutaneous Flaps.” In Wound Repair and Regeneration, 26:A15–A15. WILEY, 2018.

Scholars@Duke

Ibrahim, Mohamed M., Ryan M. Schweller, Mahmoud M. Mohammed, David B. Powers, and Bruce Klitzman. “Implantable Oxygen Platform for Continuous, Real-time Detection of Vascular Perfusion and Ischemia.” In Wound Repair and Regeneration, 26:A8–A8. WILEY, 2018.

Scholars@Duke

Ibrahim, Mohamed, Jennifer Bond, Manuel A. Medina, Lei Chen, Carlos Quiles, George Kokosis, Latif Bashirov, Bruce Klitzman, and Howard Levinson. “Characterization of the Foreign Body Response to Common Surgical Biomaterials in a Murine Model.” Eur J Plast Surg 40, no. 5 (November 2017): 383–92. https://doi.org/10.1007/s00238-017-1308-9.

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