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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989

Publications

Marroquin, Carlos E., J Elizabeth Tuttle-Newhall, Bradley H. Collins, Paul C. Kuo, and Rebecca A. Schroeder. “Emergencies after liver transplantation..” Semin Gastrointest Dis 14, no. 2 (April 2003): 101–10.

Scholars@Duke

Elshewy, H., W. Kendall, M. Darrabie, B. H. Collins, and E. C. Opara. “Islet cell intregrity and function after freezing with various cryoprotectants.” In Cell Transplantation, 12:184–184. COGNIZANT COMMUNICATION CORP, 2003.

Scholars@Duke

Stephenson, G. R., L. A. Szczech, B. H. Collins, P. C. Kuo, M. A. Hereghan, E. Moretti, and J. E. Tuttle-Newhall. “Mutivariate analysis of risk factors for chevron incisional hernia formation following liver transplantation..” In Hepatology, 36:672A-672A. W B SAUNDERS CO, 2002.

Scholars@Duke

Tuttle-Newhall, J. E., B. H. Collins, S. N. Vaslef, P. C. Kuo, E. Piantadosi, G. R. Stephenson, M. A. Heneghan, and N. W. Knudsen. “The effect of pre-transplant MELD score on length of stay and hospital charges after orthotopic liver transplantation..” In Hepatology, 36:193A-193A. W B SAUNDERS CO, 2002.

Scholars@Duke

Kendall, W. F., H. A. Hobbs, M. D. Darrabie, B. H. Collins, and E. C. Opara. “Alginate bead swelling and polymorphism: Effect of Na2SO4 treatment.” In Faseb Journal, 15:A727–A727. FEDERATION AMER SOC EXP BIOL, 2001.

Scholars@Duke

Kendall, W., M. Darrabie, B. Freeman, H. Hobbs, B. Collins, and E. Opara. “Effect of bead swelling on the durability of polylysine alginate microcapsules.” Current Surgery 57, no. 6 (November 2000): 636–37. https://doi.org/10.1016/s0149-7944(00)00354-8.

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