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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989
Weight: 
-20

Publications

Kendall, W. F., M. D. Darrabie, H. M. El-Shewy, and E. C. Opara. “Effect of alginate composition and purity on alginate microspheres.” Journal of Microencapsulation 21, no. 8 (December 2004): 821–28. https://doi.org/10.1080/02652040400015452.

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Schroeder, Rebecca A., Bradley H. Collins, Elizabeth Tuttle-Newhall, Kerri Robertson, Jeffrey Plotkin, Lynt B. Johnson, and Paul C. Kuo. “Intraoperative fluid management during orthotopic liver transplantation..” J Cardiothorac Vasc Anesth 18, no. 4 (August 2004): 438–41. https://doi.org/10.1053/j.jvca.2004.05.020.

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El-Shewy, Hesham M., F Kendall William, Marcus Darrabie, Bradley H. Collins, and Emmanuel C. Opara. “Polyvinyl Pyrrolidone: A Novel Cryoprotectant in Islet Cell Cryopreservation..” Cell Transplant 13, no. 3 (April 2004): 237–43. https://doi.org/10.3727/000000004783983927.

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Palestrant, Daniel, Zoie E. Holzknecht, Bradley H. Collins, William Parker, Sara E. Miller, and R Randal Bollinger. “Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining..” Ultrastruct Pathol 28, no. 1 (January 2004): 23–27.

Scholars@Duke

Collins, B. H., C. E. Marroquin, J. E. Tuttle-Newhall, D. M. Desai, S. R. Smith, D. W. Butterly, R. R. Bollinger, and P. C. Kuo. “The management of end stage renal disease in the recipients of extrarenal transplants.” In American Journal of Transplantation, 4:537–537. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Rocha, Paulo N., David W. Butterly, Arthur Greenberg, Donal N. Reddan, Janet Tuttle-Newhall, Bradley H. Collins, Paul C. Kuo, et al. “Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection..” Transplantation 75, no. 9 (May 15, 2003): 1490–95. https://doi.org/10.1097/01.TP.0000060252.57111.AC.

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Heneghan, Michael A., J Elizabeth Tuttle-Newhall, Paul V. Suhocki, Andrew J. Muir, Michael Morse, Jeffrey D. Bornstein, Pamela B. Sylvestre, Bradley Collins, Paul C. Kuo, and Don C. Rockey. “De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant..” Am J Transplant 3, no. 5 (May 2003): 634–38. https://doi.org/10.1034/j.1600-6143.2003.00110.x.

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Tuttle-Newhall, Janet E., Bradley H. Collins, Paul C. Kuo, and Rebecca Schoeder. “Organ donation and treatment of the multi-organ donor..” Curr Probl Surg 40, no. 5 (May 2003): 266–310. https://doi.org/10.1016/S0011-3840(03)00011-X.

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