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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Chinnadurai, Raghavan, Ian B. Copland, Marco A. Garcia, Christopher T. Petersen, Christopher N. Lewis, Edmund K. Waller, Allan D. Kirk, and Jacques Galipeau. “Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.” Stem Cells 34, no. 9 (September 2016): 2429–42.

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Kirk, A. D., P. S. Malchesky, R. Shapiro, S. A. Webber, H. H. Hirsch, F. M. Marty, R. Oberbauer, et al. “Introducing the Wiley Transplant Peer Review Network.” Am J Transplant 16, no. 9 (September 2016): 2505–7.

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Buchman, Timothy G., Timothy R. Billiar, Eric Elster, Allan D. Kirk, Ramzy H. Rimawi, Yoram Vodovotz, and Barbara A. Zehnbauer. “Precision Medicine for Critical Illness and Injury.” Crit Care Med 44, no. 9 (September 2016): 1635–38.

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Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.” Am J Transplant 16, no. 9 (September 2016): 2612–23.

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Kirk, Allan D., Paul S. Malchesky, Ron Shapiro, Steven A. Webber, Hans H. Hirsch, Francisco M. Marty, Rainer Oberbauer, et al. “Introducing The Wiley Transplant Peer Review Network.” Artif Organs 40, no. 7 (July 2016): 635–37.

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Cendales, Linda C., Matthew Levine, Stephen Bartlett, Jennifer Cheeseman, Cinthia I. Drachenberg, Wayne W. Hancock, Marybeth Joshi, et al. “Skin as a harbinger of rejection of underlying structures in VCA: Concordance or discordance?” In Transplantation, 100:S813–S813. LIPPINCOTT WILLIAMS & WILKINS, 2016.


Anderson, D. J., D. J. Lo, F. Leopardi, M. Song, N. A. Turgeon, E. A. Strobert, J. B. Jenkins, et al. “Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection.” Am J Transplant 16, no. 5 (May 2016): 1456–64.

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Espinosa, J., F. Herr, G. Tharp, S. Bosinger, M. Song, A. B. Farris, R. George, et al. “CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection.” Am J Transplant 16, no. 4 (April 2016): 1102–12.

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