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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos Abramowsky, Asha Shenoi, Astrid Kosters, Haritha Pavuluri, Frank Anania, and Allan D. Kirk. “Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver.” Am J Physiol Gastrointest Liver Physiol 307, no. 11 (December 1, 2014): G1088–99.

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Singh, K., L. Stempora, R. D. Harvey, A. D. Kirk, C. P. Larsen, B. R. Blazar, and L. S. Kean. “Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.” Am J Transplant 14, no. 12 (December 2014): 2691–2703.

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Roedder, Silke, Tara Sigdel, Nathan Salomonis, Sue Hsieh, Hong Dai, Oriol Bestard, Diana Metes, et al. “The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study.” Plos Med 11, no. 11 (November 2014): e1001759.

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Chinnadurai, Raghavan, Marco A. Garcia, Yumiko Sakurai, Wilbur A. Lam, Allan D. Kirk, Jacques Galipeau, and Ian B. Copland. “Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo.” Stem Cell Reports 3, no. 1 (July 8, 2014): 60–72.

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Samy, Kannan P., Benjamin M. Martin, Nicole A. Turgeon, and Allan D. Kirk. “Islet cell xenotransplantation: a serious look toward the clinic.” Xenotransplantation 21, no. 3 (May 2014): 221–29.

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Kirk, A. D., A. Guasch, H. Xu, J. Cheeseman, S. I. Mead, A. Ghali, A. K. Mehta, et al. “Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.” Am J Transplant 14, no. 5 (May 2014): 1142–51.

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Neujahr, D. C., K. Uppal, S. D. Force, F. Fernandez, C. Lawrence, A. Pickens, R. Bag, et al. “Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation.” Am J Transplant 14, no. 4 (April 2014): 841–48.

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O’Leary, J. G., A. J. Demetris, L. S. Friedman, H. M. Gebel, P. F. Halloran, A. D. Kirk, S. J. Knechtle, et al. “The role of donor-specific HLA alloantibodies in liver transplantation.” Am J Transplant 14, no. 4 (April 2014): 779–87.

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