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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Shaw, B. I., D. K. Cheng, Q. Cheng, C. R. Acharya, A. D. Kirk, and E. T. Chambers. “A Novel Genomic Approach for Acute Rejection across All Age Groups in Kidney Transplantation.” In American Journal of Transplantation, 19:519–519. WILEY, 2019.


Shaw, B. I., L. Stempora, C. Chan, R. B. Ettenger, P. C. Grimm, H. Lee, E. F. Reed, et al. “Antithymocyte Globulin is Associated with Mature T Cell Phenotypes and Decreased Risk of Non-EBV Infections in Transplanted Children.” In American Journal of Transplantation, 19:466–67. WILEY, 2019.


Song, M., K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, and A. D. Kirk. “CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation.” In American Journal of Transplantation, 19:430–430. WILEY, 2019.


Schmitz, R., M. S. Mulvihill, P. M. Schroder, Z. Fitch, F. Leopardi, D. Magnani, J. Kwun, S. J. Knechtle, and A. D. Kirk. “Depletional Induction Therapy in Non-Human Primates - Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG.” In American Journal of Transplantation, 19:597–597. WILEY, 2019.


Klintmalm, Goran B., Bruce Kaplan, and Allan D. Kirk. “FDA jeopardizes the lives of lung transplant recipients and in the process severely increases the cost to develop new immunosuppression.” Am J Transplant 19, no. 4 (April 2019): 971–72.

Full Text

Fitch, Z. W., Q. Gao, R. P. Davis, M. S. Mulvihill, M. Song, F. Leopardi, M. Ribeiro, et al. “Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens.” In American Journal of Transplantation, 19:473–74. WILEY, 2019.


Chambers, E. T., O. Martinez, M. Robien, C. Chan, R. Ettenger, P. Grimm, H. Lee, et al. “NK Cells Are Associated with Alloimmune Failure in Transplanted Children.” In American Journal of Transplantation, 19:339–339. WILEY, 2019.


Lubkin, David T., Muath Bishawi, Andrew S. Barbas, Todd V. Brennan, and Allan D. Kirk. “Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.” Crit Care Med 46, no. 12 (December 2018): 2018–28.

Full Text