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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Neujahr, DC, Uppal, K, Force, SD, Fernandez, F, Lawrence, C, Pickens, A, Bag, R, Lockard, C, Kirk, AD, Tran, V, Lee, K, Jones, DP, and Park, Y. "Bile Acid Aspiration Associated With Lung Chemical Profile Linked to Other Biomarkers of Injury After Lung Transplantation." American Journal of Transplantation 14, no. 4 (April 2014): 841-848.

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Lo, DJ, Kaplan, B, and Kirk, AD. "Biomarkers for kidney transplant rejection." Nature Reviews Nephrology 10, no. 4 (April 2014): 215-225.

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O'Leary, JG, Demetris, AJ, Friedman, LS, Gebel, HM, Halloran, PF, Kirk, AD, Knechtle, SJ, McDiarmid, SV, Shaked, A, Terasaki, PI, Tinckam, KJ, Tomlanovich, SJ, Wood, KJ, Woodle, ES, Zachary, AA, and Klintmalm, GB. "The role of donor-specific HLA alloantibodies in liver transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 4 (April 2014): 779-787.

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Krummey, SM, Cheeseman, JA, Conger, JA, Jang, PS, Mehta, AK, Kirk, AD, Larsen, CP, and Ford, ML. "High CTLA-4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA-4 Coinhibition and Resistance to Belatacept." American Journal of Transplantation 14, no. 3 (March 2014): 607-614.

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Rosenblum, JM, and Kirk, AD. "Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy." Immunological Reviews 258, no. 1 (March 2014): 167-182.

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Xu, H, Perez, SD, Cheeseman, J, Mehta, AK, and Kirk, AD. "The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 2 (February 2014): 319-332.

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Kim, EJ, Kwun, J, Gibby, AC, Hong, JJ, Farris, AB, Iwakoshi, NN, Villinger, F, Kirk, AD, and Knechtle, SJ. "Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 1 (January 2014): 59-69.

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Lo, DJ, Farris, AB, Song, M, Leopardi, F, Anderson, DJ, Strobert, EA, Ramakrishnan, S, Turgeon, NA, Mehta, AK, Turnbull, B, Maroni, B, Violette, SM, and Kirk, AD. "Inhibition of αvβ6 Promotes Acute Renal Allograft Rejection in Nonhuman Primates." American Journal of Transplantation 13, no. 12 (December 2013): 3085-3093.

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Koura, DT, Horan, JT, Langston, AA, Qayed, M, Mehta, A, Khoury, HJ, Harvey, RD, Suessmuth, Y, Couture, C, Carr, J, Grizzle, A, Johnson, HR, Cheeseman, JA, Conger, JA, Robertson, J, Stempora, L, Johnson, BE, Garrett, A, Kirk, AD, Larsen, CP, Waller, EK, and Kean, LS. "In Vivo T Cell Costimulation Blockade with Abatacept for Acute Graft-versus-Host Disease Prevention: A First-in-Disease Trial." Biology of Blood and Marrow Transplantation 19, no. 11 (November 2013): 1638-1649.

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Beus, JM, Hashmi, SS, Selvaraj, SA, Duan, D, Stempora, LL, Monday, SA, Cheeseman, JA, Hamby, KM, Speck, SH, Larsen, CP, Kirk, AD, and Kean, LS. "Heterologous Immunity Triggered by a Single, Latent Virus in Mus musculus: Combined Costimulation- and Adhesion- Blockade Decrease Rejection." Edited by D Unutmaz. PLoS ONE 8, no. 8 (August 5, 2013): e71221-e71221.

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