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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Gupta, NA, Kolachala, VL, Jiang, R, Abramowsky, C, Shenoi, A, Kosters, A, Pavuluri, H, Anania, F, and Kirk, AD. "Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver." American Journal of Physiology. Gastrointestinal and Liver Physiology 307, no. 11 (December 2014): G1088-G1099.

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Singh, K, Stempora, L, Harvey, RD, Kirk, AD, Larsen, CP, Blazar, BR, and Kean, LS. "Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 12 (December 2014): 2691-2703.

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Roedder, S, Sigdel, T, Salomonis, N, Hsieh, S, Dai, H, Bestard, O, Metes, D, Zeevi, A, Gritsch, A, Cheeseman, J, Macedo, C, Peddy, R, Medeiros, M, Vincenti, F, Asher, N, Salvatierra, O, Shapiro, R, Kirk, A, Reed, EF, and Sarwal, MM. "The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study." Plos Medicine 11, no. 11 (November 11, 2014): e1001759-null.

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Mou, D, Espinosa, J, Lo, DJ, and Kirk, AD. "CD28 negative T cells: is their loss our gain?." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 11 (November 2014): 2460-2466. (Review)

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Chinnadurai, R, Garcia, MA, Sakurai, Y, Lam, WA, Kirk, AD, Galipeau, J, and Copland, IB. "Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo." Stem Cell Reports 3, no. 1 (July 2014): 60-72.

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Samy, KP, Martin, BM, Turgeon, NA, and Kirk, AD. "Islet cell xenotransplantation: a serious look toward the clinic." Xenotransplantation 21, no. 3 (May 8, 2014): 221-229. (Review)

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Kirk, AD, Guasch, A, Xu, H, Cheeseman, J, Mead, SI, Ghali, A, Mehta, AK, Wu, D, Gebel, H, Bray, R, Horan, J, Kean, LS, Larsen, CP, and Pearson, TC. "Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 5 (May 2014): 1142-1151.

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Neujahr, DC, Uppal, K, Force, SD, Fernandez, F, Lawrence, C, Pickens, A, Bag, R, Lockard, C, Kirk, AD, Tran, V, Lee, K, Jones, DP, and Park, Y. "Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 4 (April 2014): 841-848.

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Lo, DJ, Kaplan, B, and Kirk, AD. "Biomarkers for kidney transplant rejection." Nature Reviews. Nephrology 10, no. 4 (April 2014): 215-225. (Review)

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O'Leary, JG, Demetris, AJ, Friedman, LS, Gebel, HM, Halloran, PF, Kirk, AD, Knechtle, SJ, McDiarmid, SV, Shaked, A, Terasaki, PI, Tinckam, KJ, Tomlanovich, SJ, Wood, KJ, Woodle, ES, Zachary, AA, and Klintmalm, GB. "The role of donor-specific HLA alloantibodies in liver transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 4 (April 2014): 779-787.

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