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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Kirk, A. D., M. A. Ibrahim, R. R. Bollinger, D. V. Dawson, and O. J. Finn. “Renal allograft-infiltrating lymphocytes. A prospective analysis of in vitro growth characteristics and clinical relevance.” Transplantation 53, no. 2 (February 1992): 329–38.

Full Text

Kirk, A. D., and O. J. Finn. “T cells expressing the antigen receptor mediate non-MHC directed human renal allograft cytotoxicity.” Surgical Forum 52 (1991): 384–86.


Weiss, E. A., A. D. Kirk, and J. A. Wolfe. “The appearance of major histocompatibilit y complex class II antigens in rat small bowel allograft-induced graft-versus-host disease.” Transplantation Proceedings 19, no. 3 (January 1, 1987): 3019–21.