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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Kenyon, N. S., M. Chatzipetrou, M. Masetti, A. Ranuncoli, M. Oliveira, J. L. Wagner, A. D. Kirk, D. M. Harlan, L. C. Burkly, and C. Ricordi. “Engraftment and long-term survival of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154 (hu5c8).” In Diabetes, 48:A59–A59. AMER DIABETES ASSOC, 1999.

Scholars@Duke

Burlingham, W., S. Kusaka, L. Chin, D. Hullett, S. Knechtle, H. Sollinger, T. Oberley, J. Pirsch, A. D. Kirk, and B. N. Becker. “Focal infiltrates in kidney allografts: developing a model for clinical transplant peripheral tolerance.” Graft 2 (1999): 253–60.

Scholars@Duke

Knechtle, S. J., A. D. Kirk, J. H. Fechner, X. Hong, Y. Dong, M. M. Hamawy, and D. M. Harlan. “Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand.” Transplantation Proceedings 31, no. 3 SUPPL. 2 (January 1, 1999): 27S-28S. https://doi.org/10.1016/S0041-1345(99)00100-1.

Full Text

Kirk, A. D. “Let’s blame the little guys: platelets as an instigator of allograft rejection.” Graft, 1999.

Scholars@Duke

Kirk, A. D. “Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories..” Crit Rev Immunol 19, no. 5–6 (1999): 349–88.

Scholars@Duke

Armstrong, N., P. Buckley, T. Oberley, J. Fechner, Y. Dong, X. Hong, A. Kirk, D. Neville, and S. Knechtle. “Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9..” Transplantation 66, no. 1 (July 15, 1998): 5–13.

Scholars@Duke

Harlan, D. M., and A. D. Kirk. “Anti-CD154 therapy to prevent graft rejection.” Graft 1 (1998): 63–63.

Scholars@Duke

Van der Werf, W. J., A. M. D’Alessandro, S. J. Knechtle, G. Pilli, R. M. Hoffmann, R. H. Judd, J. S. Odorico, et al. “Infant pediatric liver transplantation results equal those for older pediatric patients..” J Pediatr Surg 33, no. 1 (January 1998): 20–23.

Scholars@Duke

Kirk, A. D., L. M. Jacobson, D. M. Heisey, N. A. Fass, H. W. Sollinger, and J. D. Pirsch. “Posttransplant diastolic hypertension: associations with intragraft transforming growth factor-beta, endothelin, and renin transcription..” Transplantation 64, no. 12 (December 27, 1997): 1716–20.

Scholars@Duke

Kirk, A. D., D. M. Harlan, N. N. Armstrong, T. A. Davis, Y. Dong, G. S. Gray, X. Hong, D. Thomas, J. H. Fechner, and S. J. Knechtle. “CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates..” Proc Natl Acad Sci U S A 94, no. 16 (August 5, 1997): 8789–94. https://doi.org/10.1073/pnas.94.16.8789.

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