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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Roedder, Silke, Tara Sigdel, Szu-Chuan Hsieh, Jennifer Cheeseman, Diana Metes, Camila Macedo, Elaine F. Reed, et al. “Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection.” Front Med (Lausanne) 4 (2017): 185. https://doi.org/10.3389/fmed.2017.00185.

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George, Roshan P., Aneesh K. Mehta, Sebastian D. Perez, Pamela Winterberg, Jennifer Cheeseman, Brandi Johnson, Jean Kwun, et al. “Premature T Cell Senescence in Pediatric CKD.” Journal of the American Society of Nephrology : Jasn 28, no. 1 (January 2017): 359–67. https://doi.org/10.1681/ASN.2016010053.

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Land, W. G., P. Agostinis, S. Gasser, A. D. Garg, and A. Linkermann. “DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing.” Am J Transplant 16, no. 12 (December 2016): 3322–37. https://doi.org/10.1111/ajt.14012.

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Klintmalm, G. B., F. Vincenti, and A. Kirk. “Steroid-Responsive Acute Rejection Should Not Be the End Point for Immunosuppressive Trials.” Am J Transplant 16, no. 11 (November 2016): 3077–78. https://doi.org/10.1111/ajt.13889.

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Darrabie, Marcus D., Jaewoo Lee, Jennifer Cheeseman, Alexander T. Limkakeng, Steven N. Vaslef, Bruce A. Sullenger, and Allan D. Kirk. “Toll-Like Receptor Signaling as a Prognostic Tool in Trauma Patients.” In Journal of the American College of Surgeons, 223:S159–60. Elsevier BV, 2016. https://doi.org/10.1016/j.jamcollsurg.2016.06.346.

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Chinnadurai, Raghavan, Ian B. Copland, Marco A. Garcia, Christopher T. Petersen, Christopher N. Lewis, Edmund K. Waller, Allan D. Kirk, and Jacques Galipeau. “Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.” Stem Cells 34, no. 9 (September 2016): 2429–42. https://doi.org/10.1002/stem.2415.

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Kirk, A. D., P. S. Malchesky, R. Shapiro, S. A. Webber, H. H. Hirsch, F. M. Marty, R. Oberbauer, et al. “Introducing the Wiley Transplant Peer Review Network.” Am J Transplant 16, no. 9 (September 2016): 2505–7. https://doi.org/10.1111/ajt.13965.

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Buchman, Timothy G., Timothy R. Billiar, Eric Elster, Allan D. Kirk, Ramzy H. Rimawi, Yoram Vodovotz, and Barbara A. Zehnbauer. “Precision Medicine for Critical Illness and Injury.” Crit Care Med 44, no. 9 (September 2016): 1635–38. https://doi.org/10.1097/CCM.0000000000002028.

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Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.” Am J Transplant 16, no. 9 (September 2016): 2612–23. https://doi.org/10.1111/ajt.13789.

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