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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Freedman, BI, Julian, BA, Pastan, SO, Israni, AK, Schladt, D, Gautreaux, MD, Hauptfeld, V, Bray, RA, Gebel, HM, Kirk, AD, Gaston, RS, Rogers, J, Farney, AC, Orlando, G, Stratta, RJ, Mohan, S, Ma, L, Langefeld, CD, Hicks, PJ, Palmer, ND, Adams, PL, Palanisamy, A, Reeves-Daniel, AM, and Divers, J. "Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 6 (June 2015): 1615-1622.

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Suessmuth, Y, Mukherjee, R, Watkins, B, Koura, DT, Finstermeier, K, Desmarais, C, Stempora, L, Horan, JT, Langston, A, Qayed, M, Khoury, HJ, Grizzle, A, Cheeseman, JA, Conger, JA, Robertson, J, Garrett, A, Kirk, AD, Waller, EK, Blazar, BR, Mehta, AK, Robins, HS, and Kean, LS. "CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire." Blood 125, no. 25 (June 2015): 3835-3850.

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Beasley, GM, Pappas, TN, and Kirk, AD. "Procedure Delegation by Attending Surgeons Performing Concurrent Operations in Academic Medical Centers: Balancing Safety and Efficiency." Annals of Surgery 261, no. 6 (June 2015): 1044-1045.

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Mou, D, Espinosa, JE, Stempora, L, Iwakoshi, NN, and Kirk, AD. "Viral-induced CD28 loss evokes costimulation independent alloimmunity." The Journal of Surgical Research 196, no. 2 (June 2015): 241-246.

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Martin, BM, Samy, KP, Lowe, MC, Thompson, PW, Cano, J, Farris, AB, Song, M, Dove, CR, Leopardi, FV, Strobert, EA, Jenkins, JB, Collins, BH, Larsen, CP, and Kirk, AD. "Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 5 (May 2015): 1241-1252.

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Lo, DJ, Anderson, DJ, Song, M, Leopardi, F, Farris, AB, Strobert, E, Chapin, S, Devens, B, Karrer, E, and Kirk, AD. "A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 4 (April 2015): 984-992.

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Velazquez, VM, Uebelhoer, LS, Thapa, M, Ibegbu, CC, Courtney, C, Bosinger, SE, Magliocca, JF, Adams, AB, Kirk, AD, Knechtle, SJ, Kalman, D, Suthar, MS, and Grakoui, A. "Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development." Hepatology (Baltimore, Md.) 61, no. 3 (March 2015): 843-856.

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MacConmara, M, Nwadei, I, and Kirk, AD. "Immunosuppressive Biologic Agents." In Transplantation of the Liver: Third Edition, 1343-1353. January 28, 2015.

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Ruiz, R, and Kirk, AD. "Long-Term Toxicity of Immunosuppressive Therapy." In Transplantation of the Liver: Third Edition, 1354-1363. January 28, 2015.

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Bray, RA, Brannon, P, Breitenbach, C, Bryan, C, Chen, D-F, Lai, J, McRacken, T, Kirk, A, Kaplan, B, Pearson, T, and Gebel, HM. "The new OPTN kidney allocation policy: potential for inequitable access among highly sensitized patients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 1 (January 2015): 284-285. (Letter)

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