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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Beasley, GM, Pappas, TN, and Kirk, AD. "Procedure Delegation by Attending Surgeons Performing Concurrent Operations in Academic Medical Centers: Balancing Safety and Efficiency." Annals of Surgery 261, no. 6 (June 2015): 1044-1045.

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Mou, D, Espinosa, JE, Stempora, L, Iwakoshi, NN, and Kirk, AD. "Viral-induced CD28 loss evokes costimulation independent alloimmunity." The Journal of Surgical Research 196, no. 2 (June 2015): 241-246.

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Martin, BM, Samy, KP, Lowe, MC, Thompson, PW, Cano, J, Farris, AB, Song, M, Dove, CR, Leopardi, FV, Strobert, EA, Jenkins, JB, Collins, BH, Larsen, CP, and Kirk, AD. "Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 5 (May 2015): 1241-1252.

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Lo, DJ, Anderson, DJ, Song, M, Leopardi, F, Farris, AB, Strobert, E, Chapin, S, Devens, B, Karrer, E, and Kirk, AD. "A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 4 (April 2015): 984-992.

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Velazquez, VM, Uebelhoer, LS, Thapa, M, Ibegbu, CC, Courtney, C, Bosinger, SE, Magliocca, JF, Adams, AB, Kirk, AD, Knechtle, SJ, Kalman, D, Suthar, MS, and Grakoui, A. "Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development." Hepatology (Baltimore, Md.) 61, no. 3 (March 2015): 843-856.

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MacConmara, M, Nwadei, I, and Kirk, AD. "Immunosuppressive Biologic Agents." In Transplantation of the Liver: Third Edition, 1343-1353. January 28, 2015.

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Ruiz, R, and Kirk, AD. "Long-Term Toxicity of Immunosuppressive Therapy." In Transplantation of the Liver: Third Edition, 1354-1363. January 28, 2015.

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Bray, RA, Brannon, P, Breitenbach, C, Bryan, C, Chen, D-F, Lai, J, McRacken, T, Kirk, A, Kaplan, B, Pearson, T, and Gebel, HM. "The new OPTN kidney allocation policy: potential for inequitable access among highly sensitized patients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 1 (January 2015): 284-285. (Letter)

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Gupta, NA, Kolachala, VL, Jiang, R, Abramowsky, C, Shenoi, A, Kosters, A, Pavuluri, H, Anania, F, and Kirk, AD. "Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver." American Journal of Physiology. Gastrointestinal and Liver Physiology 307, no. 11 (December 2014): G1088-G1099.

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Singh, K, Stempora, L, Harvey, RD, Kirk, AD, Larsen, CP, Blazar, BR, and Kean, LS. "Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 12 (December 2014): 2691-2703.

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