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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Shaw, Brian I., Daniel K. Cheng, Chaitanya R. Acharya, Robert B. Ettenger, Herbert Kim Lyerly, Qing Cheng, Allan D. Kirk, and Eileen T. Chambers. “An age-independent gene signature for monitoring acute rejection in kidney transplantation.” Theranostics 10, no. 15 (2020): 6977–86.

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Gelbard, Rondi B., Hannah Hensman, Seth Schobel, Vivek Khatri, Brett M. Tracy, Christopher J. Dente, Timothy Buchman, Allan Kirk, and Eric Elster. “Random forest modeling can predict infectious complications following trauma laparotomy.” In J Trauma Acute Care Surg, 87:1125–32, 2019.

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Samy, Kannan P., Qimeng Gao, Robert Patrick Davis, Mingqing Song, Zachary W. Fitch, Michael S. Mulvihill, Andrea L. MacDonald, et al. “The role of human CD46 in early xenoislet engraftment in a dual transplant model.” Xenotransplantation 26, no. 6 (November 2019): e12540.

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Corey, Kristin, Joshua Helmkamp, Allan D. Kirk, Suresh Balu, David Thompson, Leila Mureebe, Joshua Watson, Keith Marsolo, Lesley Curtis, and Mark Sendak. “Assessing Quality of Real-World Data Supplied by an Automated Surgical Data Pipeline.” In Journal of the American College of Surgeons, 229:S89–S89. ELSEVIER SCIENCE INC, 2019.


Lisboa, Felipe A., Christopher J. Dente, Seth A. Schobel, Vivek Khatri, Benjamin K. Potter, Allan D. Kirk, and Eric A. Elster. “Utilizing Precision Medicine to Estimate Timing for Surgical Closure of Traumatic Extremity Wounds.” Ann Surg 270, no. 3 (September 2019): 535–43.

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Eppensteiner, John, Jean Kwun, Uwe Scheuermann, Andrew Barbas, Alexander T. Limkakeng, Maggie Kuchibhatla, Eric A. Elster, Allan D. Kirk, and Jaewoo Lee. “Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness.” Jci Insight 4, no. 16 (August 22, 2019).

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Mulvihill, Michael S., Kannan P. Samy, Qimeng A. Gao, Robin Schmitz, Robert P. Davis, Brian Ezekian, Francis Leopardi, et al. “Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study.” Am J Transplant 19, no. 8 (August 2019): 2350–57.

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Lin, Liwen, He Xu, Muath Bishawi, FeiFei Feng, Kannan Samy, George Truskey, Andrew S. Barbas, Allan D. Kirk, and Todd V. Brennan. “Circulating mitochondria in organ donors promote allograft rejection.” Am J Transplant 19, no. 7 (July 2019): 1917–29.

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Anderson, Douglas J., Denise J. Lo, Francis Leopardi, Mingqing Song, Elizabeth A. Strobert, Joe B. Jenkins, Christian P. Larsen, and Allan D. Kirk. “Corticosteroids and methotrexate as adjuvants to costimulation blockade in non-human primate renal transplantation.” Clin Transplant 33, no. 6 (June 2019): e13568.

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