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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Burlingham, W., S. Kusaka, L. Chin, D. Hullett, S. Knechtle, H. Sollinger, T. Oberley, J. Pirsch, A. D. Kirk, and B. N. Becker. “Focal infiltrates in kidney allografts: developing a model for clinical transplant peripheral tolerance.” Graft 2 (1999): 253–60.

Scholars@Duke

Kirk, A. D. “Let’s blame the little guys: platelets as an instigator of allograft rejection.” Graft, 1999.

Scholars@Duke

Kirk, A. D. “Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories.” Crit Rev Immunol 19, no. 5–6 (1999): 349–88.

Scholars@Duke

Armstrong, N., P. Buckley, T. Oberley, J. Fechner, Y. Dong, X. Hong, A. Kirk, D. Neville, and S. Knechtle. “Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9.” Transplantation 66, no. 1 (July 15, 1998): 5–13. https://doi.org/10.1097/00007890-199807150-00002.

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Harlan, D. M., and A. D. Kirk. “Anti-CD154 therapy to prevent graft rejection.” Graft 1 (1998): 63–63.

Scholars@Duke

Van der Werf, W. J., A. M. D’Alessandro, S. J. Knechtle, G. Pilli, R. M. Hoffmann, R. H. Judd, J. S. Odorico, et al. “Infant pediatric liver transplantation results equal those for older pediatric patients.” J Pediatr Surg 33, no. 1 (January 1998): 20–23. https://doi.org/10.1016/s0022-3468(98)90353-0.

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Kirk, A. D., L. M. Jacobson, D. M. Heisey, N. A. Fass, H. W. Sollinger, and J. D. Pirsch. “Posttransplant diastolic hypertension: associations with intragraft transforming growth factor-beta, endothelin, and renin transcription.” Transplantation 64, no. 12 (December 27, 1997): 1716–20. https://doi.org/10.1097/00007890-199712270-00015.

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Kirk, A. D., D. M. Harlan, N. N. Armstrong, T. A. Davis, Y. Dong, G. S. Gray, X. Hong, D. Thomas, J. H. Fechner, and S. J. Knechtle. “CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.” Proc Natl Acad Sci U S A 94, no. 16 (August 5, 1997): 8789–94. https://doi.org/10.1073/pnas.94.16.8789.

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Jerome, K. R., A. D. Kirk, G. Pecher, W. W. Ferguson, and O. J. Finn. “A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis.” Cancer Immunol Immunother 43, no. 6 (January 1997): 355–60. https://doi.org/10.1007/s002620050344.

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Kirk, A. D., D. M. Heisey, A. M. D’Alessandro, S. J. Knechtle, J. S. Odorico, S. C. Rayhill, H. W. Sollinger, and J. D. Pirsch. “Clinical hepatitis after transplantation of hepatitis C virus-positive kidneys: HLA-DR3 as a risk factor for the development of posttransplant hepatitis.” Transplantation 62, no. 12 (December 27, 1996): 1758–62. https://doi.org/10.1097/00007890-199612270-00011.

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