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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Kirk, A. D., L. C. Burkly, D. S. Batty, R. E. Baumgartner, J. D. Berning, K. Buchanan, J. H. Fechner, et al. “Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.” Nat Med 5, no. 6 (June 1999): 686–93. https://doi.org/10.1038/9536.

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Knechtle, S. J., A. D. Kirk, J. H. Fechner, X. Hong, Y. Dong, M. M. Hamawy, and D. M. Harlan. “Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand.” Transplant Proc 31, no. 3B Suppl (May 1999): 27S-28S. https://doi.org/10.1016/s0041-1345(99)00100-1.

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Kenyon, Norma S., Maria Chatzipetrou, Michele Masetti, Alessandra Ranuncoli, Maria Oliveira, Joseph L. Wagner, Allan D. Kirk, David M. Harlan, Linda C. Burkly, and Camillo Ricordi. “LONG-TERM INTRAHEPATIC ISLET ALLOGRAFT SURVIVAL IN NON-HUMAN PRIMATES TREATED WITH ANTI-CD154 MONOTHERAPY.” In Transplantation, 67:S550–S550. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199905150-00057.

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Tadaki, Douglas K., Amanda Williams, Allan D. Kirk, Kelvin P. Lee, and David M. Harlan. “CLONING OF PORCINE CD80 AND CHARACTERIZATION OF HUMAN T CELL COSTIMULATORY ACTIVITY.” In Transplantation, 67:S222–S222. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199904150-00886.

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Blair, P. J., J. L. Riley, D. M. Harlan, T. E. Francomano, S. J. Perfetto, A. D. Kirk, and C. H. June. “COLIGATION OF CD40L (CD154) AND CD3 RESULTS IN CD4+ T CELL ACTIVATION AND THE INDUCTION OF APOPTOSIS.” In Transplantation, 67:S131–S131. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199904150-00528.

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Baumgartner, Roxanne E., Noelle B. Patterson, Justin Berning, Linda Burkly, Rhonda Germond, David M. Harlan, Robert Kampen, Douglas K. Tadaki, Sharda G. Sabnis, and Allan D. Kirk. “RHESUS RENAL ALLOGRAFTS CONTAIN NON-DESTRUCTIVE ACTIVATED LYMPHOCYTIC INFILTRATES FOLLOWING ANTI-CD154 THERAPY.” In Transplantation, 67:S63–S63. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199904150-00254.

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Burlingham, W. J., P. J. O’Connell, J. D. Pirsch, B. N. Becker, A. D. Kirk, L. M. Jacobson, L. T. Chin, et al. “STABILITY OF THE TOLERANCE PHENOTYPE AFTER WITHDRAWAL OF IMMUNOSUPPRESSIVE DRUG THERAPY: INFLUENCE OF LOCAL AND GENETIC FACTORS INFLUENCING TNFα AND TGFβ EXPRESSION.” In Transplantation, 67:S69–S69. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199904150-00278.

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Elster, E. A., R. L. Kampen, K. A. Robson, D. K. Tadaki, P. Perdue, R. M. McCarron, and A. D. Kirk. “Apoptosis regulatory genes BCL-2 and BAX are induced immediately following ischemic/reperfusion injury.” Surgical Forum 50 (1999): 383–84.

Scholars@Duke

Kenyon, N. S., M. Chatzipetrou, M. Masetti, A. Ranuncoli, M. Oliveira, J. L. Wagner, A. D. Kirk, D. M. Harlan, L. C. Burkly, and C. Ricordi. “Engraftment and long-term survival of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154 (hu5c8).” In Diabetes, 48:A59–A59. AMER DIABETES ASSOC, 1999.

Scholars@Duke

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