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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Rayhill, S. C., A. M. D’Alessandro, J. S. Odorico, S. J. Knechtle, J. D. Pirsch, D. M. Heisey, A. D. Kirk, W. Van der Werf, and H. W. Sollinger. “Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: is there a difference in survival?” Ann Surg 231, no. 3 (March 2000): 417–23. https://doi.org/10.1097/00000658-200003000-00015.

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Blair, P. J., J. L. Riley, D. M. Harlan, R. Abe, D. K. Tadaki, S. C. Hoffmann, L. White, et al. “CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis.” J Exp Med 191, no. 4 (February 21, 2000): 651–60. https://doi.org/10.1084/jem.191.4.651.

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Kirk, Allan D., and David M. Harlan. “Reply to Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand.” Nature Medicine 6, no. 2 (February 2000): 114–114. https://doi.org/10.1038/72164.

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Kawai, T., D. Andrews, R. B. Colvin, D. H. Sachs, and A. B. Cosimi. “Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand.” Nat Med, February 2000. https://doi.org/10.1038/72162.

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Elster, E. A., P. J. Blair, and A. D. Kirk. “Potential of costimulation-based therapies for composite tissue allotransplantation.” Microsurgery 20, no. 8 (2000): 430–34. https://doi.org/10.1002/1098-2752(2000)20:8<430::aid-micr14>3.0.co;2-k.

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Elster, Eric A., Patrick J. Blair, and Allan D. Kirk. “Potential of costimulation‐based therapies for composite tissue allotransplantation.” In Microsurgery, 20:430–34. Wiley, 2000. https://doi.org/10.1002/1098-2752(2000)20:8<430::aid-micr14>3.3.co;2-b.

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Kirk, A. D., L. M. Jacobson, D. M. Heisey, N. F. Radke, J. D. Pirsch, and H. W. Sollinger. “Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function.” Transplantation 68, no. 10 (November 27, 1999): 1578–82. https://doi.org/10.1097/00007890-199911270-00024.

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Harlan, D. M., and A. D. Kirk. “The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection?” Jama 282, no. 11 (September 15, 1999): 1076–82. https://doi.org/10.1001/jama.282.11.1076.

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Kenyon, N. S., M. Chatzipetrou, M. Masetti, A. Ranuncoli, M. Oliveira, J. L. Wagner, A. D. Kirk, D. M. Harlan, L. C. Burkly, and C. Ricordi. “Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.” Proc Natl Acad Sci U S A 96, no. 14 (July 6, 1999): 8132–37. https://doi.org/10.1073/pnas.96.14.8132.

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Kenyon, N. S., L. A. Fernandez, R. Lehmann, M. Masetti, A. Ranuncoli, M. Chatzipetrou, G. Iaria, et al. “Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.” Diabetes 48, no. 7 (July 1999): 1473–81. https://doi.org/10.2337/diabetes.48.7.1473.

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