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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

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Publications

Xu, H., D. K. Tadaki, P. J. Blair, D. M. Harlan, and A. D. Kirk. “Porcine endothelium costimulates human T cells in the absence of human antigen presenting cells (APCs)..” In Transplantation, 69:S258–S258. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Elster, E. A., H. Xu, L. C. Burkly, J. D. Berning, R. E. Baumgartner, R. L. Kampen, N. B. Patterson, D. K. Tadaki, D. M. Harlan, and A. D. Kirk. “Primary skin allograft acceptance with anti-CD154 in a non-human primate model..” In Transplantation, 69:S239–S239. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Kirk, A. D., D. K. Tadaki, H. Xu, E. A. Elster, L. C. Burkley, A. Celniker, D. S. Batty, et al. “Primate allotransplantation using costimulation blockade..” Transplantation 69, no. 8 (April 27, 2000): S414–S414.

Scholars@Duke

Becker, B. N., L. M. Jacobson, D. A. Hullett, Y. T. Becker, T. D. Oberley, and A. D. Kirk. “Type 2 angiotensin II receptor mRNA expression in human renal allografts is associated with chronic rejection..” In Transplantation, 69:S400–S400. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Becker, B. N., L. M. Jacobson, Y. T. Becker, N. A. Radke, D. M. Heisey, T. D. Oberley, J. D. Pirsch, H. W. Sollinger, P. C. Brazy, and A. D. Kirk. “Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function..” Transplantation 69, no. 7 (April 15, 2000): 1485–91. https://doi.org/10.1097/00007890-200004150-00046.

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Burlingham, W. J., P. J. O’Connell, L. M. Jacobson, B. N. Becker, A. D. Kirk, V. Pravica, and I. V. Hutchinson. “Tumor necrosis factor-alpha and tumor growth factor-beta1 genotype: partial association with intragraft gene expression in two cases of long-term peripheral tolerance to a kidney transplant..” Transplantation 69, no. 7 (April 15, 2000): 1527–30. https://doi.org/10.1097/00007890-200004150-00058.

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Rayhill, S. C., A. M. D’Alessandro, J. S. Odorico, S. J. Knechtle, J. D. Pirsch, D. M. Heisey, A. D. Kirk, W. Van der Werf, and H. W. Sollinger. “Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: is there a difference in survival?.” Ann Surg 231, no. 3 (March 2000): 417–23. https://doi.org/10.1097/00000658-200003000-00015.

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Blair, P. J., J. L. Riley, D. M. Harlan, R. Abe, D. K. Tadaki, S. C. Hoffmann, L. White, et al. “CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis..” J Exp Med 191, no. 4 (February 21, 2000): 651–60. https://doi.org/10.1084/jem.191.4.651.

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Kirk, Allan D., and David M. Harlan. “Reply to Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand.” Nature Medicine 6, no. 2 (February 2000): 114–114. https://doi.org/10.1038/72164.

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Kawai, T., D. Andrews, R. B. Colvin, D. H. Sachs, and A. B. Cosimi. “Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand..” Nat Med, February 2000. https://doi.org/10.1038/72162.

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