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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Cox, E. D., S. C. Hoffmann, B. S. DiMercurio, R. A. Wesley, D. M. Harlan, A. D. Kirk, and P. J. Blair. “Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6.” Transplantation 72, no. 4 (August 27, 2001): 720–26. https://doi.org/10.1097/00007890-200108270-00027.

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Cho, C. S., L. C. Burkly, J. H. Fechner, A. D. Kirk, T. D. Oberley, Y. Dong, K. G. Brunner, et al. “Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.” Transplantation 72, no. 4 (August 27, 2001): 587–97. https://doi.org/10.1097/00007890-200108270-00006.

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Kirk, A. D., D. K. Tadaki, A. Celniker, D. S. Batty, J. D. Berning, J. O. Colonna, F. Cruzata, et al. “Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates.” Transplantation 72, no. 3 (August 15, 2001): 377–84. https://doi.org/10.1097/00007890-200108150-00005.

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Batty, D. S., S. J. Swanson, A. D. Kirk, C. W. Ko, L. Y. Agodoa, and K. C. Abbott. “Hepatitis C virus seropositivity at the time of renal transplantation in the United States: associated factors and patient survival.” Am J Transplant 1, no. 2 (July 2001): 179–84.

Scholars@Duke

Kirk, A. D., P. J. Blair, D. K. Tadaki, H. Xu, and D. M. Harlan. “The role of CD154 in organ transplant rejection and acceptance.” Philos Trans R Soc Lond B Biol Sci 356, no. 1409 (May 29, 2001): 691–702. https://doi.org/10.1098/rstb.2001.0855.

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Hoffmann, S. C., E. M. Stanley, E. D. Cox, N. Craighead, S. P. Perfetto, D. M. Harlan, A. D. Kirk, and P. J. Blair. “The polymorphism at-330 in the interleukin-2 gene results in a significant increase in IL-2 protein following co-stimulation of peripheral blood lymphocytes with anti-CD3/CD28.” In Faseb Journal, 15:A1055–A1055. FEDERATION AMER SOC EXP BIOL, 2001.

Scholars@Duke

Hoffmann, S. C., E. M. Stanley, E. D. Cox, B. S. DiMercurio, D. E. Koziol, D. M. Harlan, A. D. Kirk, and P. J. Blair. “Correlation of cytokine gene polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28 stimulated peripheral blood lymphocytes.” In Faseb Journal, 15:A666–A666. FEDERATION AMER SOC EXP BIOL, 2001.

Scholars@Duke

Abbott, K. C., J. D. Oliver, I. Hypolite, L. L. Lepler, A. D. Kirk, C. W. Ko, C. A. Hawkes, C. A. Jones, and L. Y. Agodoa. “Hospitalizations for bacterial septicemia after renal transplantation in the united states.” Am J Nephrol 21, no. 2 (March 2001): 120–27. https://doi.org/10.1159/000046234.

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Xu, H., E. Elster, D. Batty, J. Berning, L. Burkly, R. Kampen, S. Swanson, D. Tadaki, D. Harlan, and A. Kirk. “Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model.” Transplant Proc 33, no. 1–2 (February 2001): 223–24. https://doi.org/10.1016/s0041-1345(00)01983-7.

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Abbott, K. C., E. S. Sawyers, J. D. Oliver, C. W. Ko, A. D. Kirk, P. G. Welch, T. G. Peters, and L. Y. Agodoa. “Graft loss due to recurrent focal segmental glomerulosclerosis in renal transplant recipients in the United States.” Am J Kidney Dis 37, no. 2 (February 2001): 366–73. https://doi.org/10.1053/ajkd.2001.21311.

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