Skip to main content

Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Li, Rui-Mei, Roslyn B. Mannon, David Kleiner, Maria Tsokos, Michelle Bynum, Allen D. Kirk, and Jeffrey B. Kopp. “BK virus and SV40 co-infection in polyomavirus nephropathy.” Transplantation 74, no. 11 (December 15, 2002): 1497–1504. https://doi.org/10.1097/00007890-200212150-00004.

Full Text

Montgomery, Sean P., He Xu, Douglas K. Tadaki, Abbie Celniker, Linda C. Burkly, Justin D. Berning, Francis Cruzata, et al. “Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.” Transplantation 74, no. 10 (November 27, 2002): 1365–69. https://doi.org/10.1097/00007890-200211270-00002.

Full Text

Swanson, S John, Douglas A. Hale, Roslyn B. Mannon, David E. Kleiner, Linda C. Cendales, Christine E. Chamberlain, Shirley M. Polly, David M. Harlan, and Allan D. Kirk. “Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.” Lancet 360, no. 9346 (November 23, 2002): 1662–64. https://doi.org/10.1016/S0140-6736(02)11606-0.

Full Text

Xu, He, Douglas K. Tadaki, Eric A. Elster, Linda C. Burkly, Justin D. Berning, Francis Cruzata, Robert L. Kampen, et al. “Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.” Transplantation 74, no. 7 (October 15, 2002): 940–43. https://doi.org/10.1097/00007890-200210150-00007.

Full Text

Hoffmann, Steven C., Robert L. Kampen, Shashi Amur, Muhammad A. Sharaf, David E. Kleiner, Keith Hunter, S. John Swanson, et al. “Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury.” Transplantation 74, no. 7 (October 15, 2002): 916–23. https://doi.org/10.1097/00007890-200210150-00003.

Full Text

Swanson, S. J., A. D. Kirk, C. W. Ko, C. A. Jones, L. Y. Agodoa, and K. C. Abbott. “Impact of HIV seropositivity on graft and patient survival after cadaveric renal transplantation in the United States in the pre highly active antiretroviral therapy (HAART) era: an historical cohort analysis of the United States Renal Data System.” Transpl Infect Dis 4, no. 3 (September 2002): 144–47. https://doi.org/10.1034/j.1399-3062.2002.01009.x.

Full Text

Hoffmann, Steven C., Eran M. Stanley, E Darrin Cox, Barbara S. DiMercurio, Deloris E. Koziol, David M. Harlan, Allan D. Kirk, and Patrick J. Blair. “Ethnicity greatly influences cytokine gene polymorphism distribution.” Am J Transplant 2, no. 6 (July 2002): 560–67. https://doi.org/10.1034/j.1600-6143.2002.20611.x.

Full Text

Hirshberg, Boaz, Sean Montgomery, Michael G. Wysoki, He Xu, Doug Tadaki, Janet Lee, Kenneth Hines, et al. “Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site.” Diabetes 51, no. 7 (July 2002): 2135–40. https://doi.org/10.2337/diabetes.51.7.2135.

Full Text

Rother, K. I., A. E. Sumner, B. Hirshberg, J. Lee, J. Gaglia, K. Hines, N. Patterson, E. J. Read, A. D. Kirk, and D. M. Harlan. “Assessment of insulin and C-peptide secretion after islet transplantation.” In Diabetes, 51:A33–A33. AMER DIABETES ASSOC, 2002.

Scholars@Duke

Hirshberg, B., K. I. Rother, J. Lee, J. Gaglia, K. Hines, N. Patterson, E. J. Reed, et al. “Islet transplantation: The NIH experience.” In Diabetes, 51:A33–A33. AMER DIABETES ASSOC, 2002.

Scholars@Duke

Pages