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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Tzakis, A. G., T. Kato, S. Nishida, D. Levi, J. Madariaga, W. De Faria, J. Nery, G. Neff, A. D. Kirk, and P. Ruiz. “Campath-1H in intestinal and multivisceral transplantation: preliminary data.” Transplant Proc 34, no. 3 (May 2002): 937. https://doi.org/10.1016/s0041-1345(02)02679-9.

Full Text

Montgomery, Sean P., Steven R. Mog, He Xu, Douglas K. Tadaki, Boaz Hirshberg, Justin D. Berning, John Leconte, David M. Harlan, Douglas Hale, and Allan D. Kirk. “Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model.” Am J Transplant 2, no. 4 (April 2002): 381–85. https://doi.org/10.1034/j.1600-6143.2002.20415.x.

Full Text

Irwin, G., A. D. Kirk, I. Mackay, and J. Nera. “Photochemistry and photophysics of Cr(III) macrocyclic complexes.” Inorg Chem 41, no. 4 (February 25, 2002): 874–83. https://doi.org/10.1021/ic010236j.

Full Text

Swanson, S John, Iman O. Hypolite, Lawrence Y. C. Agodoa, D Scott Batty, Paul B. Hshieh, David Cruess, Allan D. Kirk, Thomas G. Peters, and Kevin C. Abbott. “Effect of donor factors on early graft survival in adult cadaveric renal transplantation.” Am J Transplant 2, no. 1 (January 2002): 68–75. https://doi.org/10.1034/j.1600-6143.2002.020112.x.

Full Text

Becker, B. N., L. M. Jacobson, D. A. Hullett, N. A. Radke, T. D. Oberley, P. C. Brazy, and A. D. Kirk. “Type 2 angiotensin II receptor expression in human renal allografts: an association with chronic allograft nephropathy.” Clinical Nephrology 57, no. 1 (January 1, 2002): 19–26.

Scholars@Duke

Becker, B. N., L. M. Jacobson, D. A. Hullett, N. A. Radke, T. D. Oberley, P. C. Brazy, and A. D. Kirk. “Type 2 angiotensin II receptor expression in human renal allografts: an association with chronic allograft nephropathy.” Clin Nephrol 57, no. 1 (January 2002): 19–26. https://doi.org/10.5414/cnp57019.

Full Text

Kleiner, D. E., S. M. Hewitt, D. A. Hale, R. B. Mannon, S. J. Swanson, and A. D. Kirk. “Unusual immunologic response to renal allografts in patients receiving CAMPATH-1H as a sole immunosuppressant.” In Modern Pathology, 15:278A-278A. NATURE PUBLISHING GROUP, 2002.

Scholars@Duke

Kleiner, D. E., S. M. Hewitt, D. A. Hale, R. B. Mannon, S. J. Swanson, and A. D. Kirk. “Unusual immunologic response to renal allografts in patients receiving CAMPATH-1H as a sole immunosuppressant.” In Laboratory Investigation, 82:278A-278A. NATURE PUBLISHING GROUP, 2002.

Scholars@Duke

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