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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin, Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Pearl, Jonathan P., Edwin Preston, and Allan D. Kirk. “Tolerance: is it achievable in pediatric solid organ transplantation?” Pediatr Clin North Am 50, no. 6 (December 2003): 1261–vii. https://doi.org/10.1016/s0031-3955(03)00120-2.

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Xu, He, Eric A. Elster, Patrick J. Blair, Linda C. Burkly, Douglas K. Tadaki, David M. Harlan, and Allan D. Kirk. “Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation.” Am J Transplant 3, no. 11 (November 2003): 1350–54. https://doi.org/10.1046/j.1600-6135.2003.00235.x.

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Pearl, J. P., M. Roederer, and A. D. Kirk. “Cyclosporine a uniquely inhibits the function of depletion-resistant memory cells.” In Journal of the American College of Surgeons, 197:S90–S90. ELSEVIER SCIENCE INC, 2003.

Scholars@Duke

Hoffmann, Steven C., Jonathan P. Pearl, Patrick J. Blair, and Allan D. Kirk. “Immune profiling: molecular monitoring in renal transplantation.” Front Biosci 8 (September 1, 2003): e444–62. https://doi.org/10.2741/1167.

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Gorbach, Alexander, Donna Simonton, Douglas A. Hale, S John Swanson, and Allan D. Kirk. “Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging.” Am J Transplant 3, no. 8 (August 2003): 988–93. https://doi.org/10.1034/j.1600-6143.2003.00158.x.

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Hirshberg, Boaz, Edwin H. Preston, He Xu, Michel G. Tal, Ziv Neeman, David Bunnell, Scott Soleimanpour, Douglas A. Hale, Allan D. Kirk, and David M. Harlan. “Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.” Transplantation 76, no. 1 (July 15, 2003): 55–60. https://doi.org/10.1097/01.TP.0000068899.48252.1D.

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Kirk, Allan D., Douglas A. Hale, Roslyn B. Mannon, David E. Kleiner, Steven C. Hoffmann, Robert L. Kampen, Linda K. Cendales, Douglas K. Tadaki, David M. Harlan, and S John Swanson. “Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).” Transplantation 76, no. 1 (July 15, 2003): 120–29. https://doi.org/10.1097/01.TP.0000071362.99021.D9.

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Tadaki, D. K., A. Williams, K. P. Lee, A. D. Kirk, and D. M. Harlan. “Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation.” Xenotransplantation 10, no. 3 (May 2003): 252–58. https://doi.org/10.1034/j.1399-3089.2003.02004.x.

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Cendales, Linda C., S John Swanson, Allan D. Kirk, Roslyn B. Mannon, and Douglas A. Hale. “Delayed autotransplantation of a solitary kidney facilitated by pump perfusion preservation.” Surgery 133, no. 4 (April 2003): 438–39. https://doi.org/10.1067/msy.2003.129.

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