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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin, Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Czapiga, Meggan, Allan D. Kirk, and Julie Lekstrom-Himes. “Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation.” Exp Hematol 32, no. 2 (February 2004): 135–39. https://doi.org/10.1016/j.exphem.2003.11.004.

Full Text

Xu, H., X. J. Zhang, R. B. Mannon, and A. D. Kirk. “A nuclear factor-kappa B inhibitor, BAY 11-7082, inhibits interactions between human endothelial cells, T-cells, and monocytes.” In American Journal of Transplantation, 4:286–286. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Pearl, J. P., H. Xu, K. L. Christopher, F. Leopardi, E. Preston, L. Cendales, D. Hale, and A. D. Kirk. “Aggressive lymphocyte depletion does not eliminate immune memory.” In American Journal of Transplantation, 4:302–302. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Dhanireddy, K. K., H. Xu, E. H. Preston, J. P. Pearl, F. V. Leopardi, L. B. Johnson, and A. D. Kirk. “Alloantibody develops coincident with rejection of skin and renal allografts in non-human primates treated with the anti CD-154 monoclonal antibody IDEC-131 combined with donor specific transfusion (DST) and sirolimus.” In American Journal of Transplantation, 4:332–332. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Mannon, R. B., D. Post, R. Kowalski, A. D. Kirk, D. Hale, and J. Britz. “Assessing immune reconsitution: Monitoring lymphocyte immune function following depletional therapy using the ImmunKnow (TM) assay.” In American Journal of Transplantation, 4:222–222. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Cendales, L. C., D. Kleiner, M. A. Eckhaus, R. Kampen, and A. D. Kirk. “Characterization of human and non-human primate composite tissue allograft rejection.” In American Journal of Transplantation, 4:341–341. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Cendales, L. C., X. J. Zhang, H. Xu, J. Bacher, and A. D. Kirk. “Composite tissue allotransplantation: Development of a non-human primate model.” In American Journal of Transplantation, 4:508–508. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Elster, E. A., D. Hale, L. B. Cendales, D. Kleiner, M. Ring, B. Niles, S. J. Swanson, R. B. Mannon, and A. D. Kirk. “Correlation of renal resistance index and biopsy proven chronic allograft nephropathy: A part of the general transplant physical exam.” In American Journal of Transplantation, 4:485–485. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Mannon, R. B., S. C. Hoffman, R. Kampen, O. H. Cheng, D. Hale, A. D. Kirk, and D. E. Kleiner. “Death and destruction: The molecular and cellular events of polyomavirus nephropathy (PVN).” In American Journal of Transplantation, 4:307–307. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

Hoffmann, S., L. M. Jacobson, R. J. Muehrer, A. D. Kirk, S. Knechtle, and B. N. Becker. “Distinct fibrosis patterns characterize Campath-1H plus rapamycin versus traditional therapy with calcineurin inhibition.” In American Journal of Transplantation, 4:160–160. BLACKWELL MUNKSGAARD, 2004.

Scholars@Duke

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