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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Belard, Arnaud, Seth Schobel, Matthew Bradley, Benjamin Kyle Potter, Christopher Dente, Timothy Buchman, Allan Kirk, and Eric Elster. “Battlefield to Bedside: Bringing Precision Medicine to Surgical Care.” J Am Coll Surg 226, no. 6 (June 2018): 1093–1102. https://doi.org/10.1016/j.jamcollsurg.2018.02.006.

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Samy, K. P., R. P. Davis, Q. Gao, B. M. Martin, M. Song, J. Cano, A. B. Farris, et al. “Early barriers to neonatal porcine islet engraftment in a dual transplant model.” Am J Transplant 18, no. 4 (April 2018): 998–1006. https://doi.org/10.1111/ajt.14601.

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Xu, He, Victoria A. Bendersky, Todd V. Brennan, Jaclyn R. Espinosa, and Allan D. Kirk. “IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection.” Am J Transplant 18, no. 3 (March 2018): 720–30. https://doi.org/10.1111/ajt.14589.

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Belard, Arnaud, Timothy Buchman, Christopher J. Dente, Benjamin K. Potter, Allan Kirk, and Eric Elster. “The Uniformed Services University's Surgical Critical Care Initiative (SC2i): Bringing Precision Medicine to the Critically Ill.” In Mil Med, 183:487–95, 2018. https://doi.org/10.1093/milmed/usx164.

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Song, M., M. S. Mulvihill, K. D. Williams, B. H. Collins, and A. D. Kirk. “Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque.” Journal of Medical Primatology 47, no. 1 (February 2018): 81–84. https://doi.org/10.1111/jmp.12285.

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Lamanna, Jason J., Juanmarco Gutierrez, Jaclyn R. Espinosa, Jacob Wagner, Lindsey N. Urquia, Cheryl Moreton, C. Victor Hurtig, et al. “Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord.” J Clin Neurosci 48 (February 2018): 173–80. https://doi.org/10.1016/j.jocn.2017.10.033.

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Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119.” Blood Adv 2, no. 2 (January 23, 2018): 89. https://doi.org/10.1182/bloodadvances.2017015446.

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Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.” Front Immunol 9 (2018): 2323. https://doi.org/10.3389/fimmu.2018.02323.

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Daneshmand, M. A., and A. D. Kirk. “Immunosuppression in organ transplantation.” In Fischer’s Mastery of Surgery, Seventh Edition, 1:141–50, 2018.

Scholars@Duke

Espinosa, Jaclyn R., Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, et al. “T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.” Frontiers in Immunology 9 (January 2018): 1371. https://doi.org/10.3389/fimmu.2018.01371.

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