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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Klintmalm, Goran B., Bruce Kaplan, and Allan D. Kirk. “FDA jeopardizes the lives of lung transplant recipients and in the process severely increases the cost to develop new immunosuppression.” Am J Transplant 19, no. 4 (April 2019): 971–72. https://doi.org/10.1111/ajt.15215.

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Fitch, Z. W., Q. Gao, R. P. Davis, M. S. Mulvihill, M. Song, F. Leopardi, M. Ribeiro, et al. “Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens.” In American Journal of Transplantation, 19:473–74. WILEY, 2019.

Scholars@Duke

Chambers, E. T., O. Martinez, M. Robien, C. Chan, R. Ettenger, P. Grimm, H. Lee, et al. “NK Cells Are Associated with Alloimmune Failure in Transplanted Children.” In American Journal of Transplantation, 19:339–339. WILEY, 2019.

Scholars@Duke

Lubkin, David T., Muath Bishawi, Andrew S. Barbas, Todd V. Brennan, and Allan D. Kirk. “Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.” Crit Care Med 46, no. 12 (December 2018): 2018–28. https://doi.org/10.1097/CCM.0000000000003381.

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Darrabie, Marcus D., Jennifer Cheeseman, Alexander T. Limkakeng, Joseph Borawski, Bruce A. Sullenger, Eric A. Elster, Allan D. Kirk, and Jaewoo Lee. “Toll-like receptor activation as a biomarker in traumatically injured patients.” J Surg Res 231 (November 2018): 270–77. https://doi.org/10.1016/j.jss.2018.05.059.

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Cendales, Linda C., David S. Ruch, Adela R. Cardones, Guy Potter, Joshua Dooley, Daniel Dore, Jonah Orr, et al. “De novo belatacept in clinical vascularized composite allotransplantation.” Am J Transplant 18, no. 7 (July 2018): 1804–9. https://doi.org/10.1111/ajt.14910.

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Belard, Arnaud, Seth Schobel, Matthew Bradley, Benjamin Kyle Potter, Christopher Dente, Timothy Buchman, Allan Kirk, and Eric Elster. “Battlefield to Bedside: Bringing Precision Medicine to Surgical Care.” J Am Coll Surg 226, no. 6 (June 2018): 1093–1102. https://doi.org/10.1016/j.jamcollsurg.2018.02.006.

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Samy, K. P., R. P. Davis, Q. Gao, B. M. Martin, M. Song, J. Cano, A. B. Farris, et al. “Early barriers to neonatal porcine islet engraftment in a dual transplant model.” Am J Transplant 18, no. 4 (April 2018): 998–1006. https://doi.org/10.1111/ajt.14601.

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Xu, He, Victoria A. Bendersky, Todd V. Brennan, Jaclyn R. Espinosa, and Allan D. Kirk. “IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection.” Am J Transplant 18, no. 3 (March 2018): 720–30. https://doi.org/10.1111/ajt.14589.

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