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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Farris, A. B., J. Kong, C. Chisolm, H. M. Gebel, R. A. Bray, C. Cohen, D. J. Brat, J. H. Saltz, A. D. Kirk, and R. Hennigar. “HLA-DR Immunohistochemistry Quantitation in Renal Allograft Biopsies: Objective Discrimination of Rejection and Other Pathologic Processes.” In Modern Pathology, 24:344A-344A. NATURE PUBLISHING GROUP, 2011.

Scholars@Duke

Lo, Denise J., Tim A. Weaver, David E. Kleiner, Roslyn B. Mannon, Lynn M. Jacobson, Bryan N. Becker, S John Swanson, Douglas A. Hale, and Allan D. Kirk. “Chemokines and their receptors in human renal allotransplantation.” Transplantation 91, no. 1 (January 15, 2011): 70–77. https://doi.org/10.1097/TP.0b013e3181fe12fc.

Full Text

Lo, D. J., T. A. Weaver, L. Stempora, A. K. Mehta, M. L. Ford, C. P. Larsen, and A. D. Kirk. “Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.” Am J Transplant 11, no. 1 (January 2011): 22–33. https://doi.org/10.1111/j.1600-6143.2010.03317.x.

Full Text

Badell, Idelberto R., Maria C. Russell, Peter W. Thompson, Alexandra P. Turner, Tim A. Weaver, Jennifer M. Robertson, Jose G. Avila, et al. “LFA-1-specific therapy prolongs allograft survival in rhesus macaques.” J Clin Invest 120, no. 12 (December 2010): 4520–31. https://doi.org/10.1172/JCI43895.

Full Text

Beus, Jonathan, Kelly Hamby, Allan D. Kirk, Christian P. Larsen, Samuel H. Speck, and Leslie Kean. “Identification of a Costimulation Blockade Resistant Mechanism of Bone Marrow Allograft Rejection Induced by Infection with a Murine EBV Homologue.” In Blood, 116:625–625. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

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