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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Ford, M. L., N. M. Reisman, T. L. Floyd, M. E. Wagener, A. D. Kirk, and C. P. Larsen. “LFA-1 Blockade Induces Effector and Regulatory T Cell Enrichment in Lymph Nodes and Increases Effector T Cell Death.” In American Journal of Transplantation, 11:153–153. WILEY-BLACKWELL, 2011.

Scholars@Duke

Srinivasan, S., A. Page, K. Singh, K. Hamby, A. Kirk, C. Larsen, and L. Kean. “New Evidence for Synergy between Combined Blockade of the CD40 and CD28/mTOR Pathways in a Rhesus Macaque Transplant Model.” In American Journal of Transplantation, 11:174–75. WILEY-BLACKWELL, 2011.

Scholars@Duke

Beus, J. M., D. Duan, S. H. Speck, C. P. Larsen, A. D. Kirk, and L. S. Kean. “Overcoming Heterologous Immunity: Virus-Mediated, Costimulation Blockade-Resistant Transplant Rejection Is Reversed by Blocking T Cell Adhesion Pathways.” In American Journal of Transplantation, 11:29–29. WILEY-BLACKWELL, 2011.

Scholars@Duke

Ferrer, I. R., M. E. Wagener, A. D. Kirk, C. P. Larsen, and M. L. Ford. “Rapamycin Augments CD8(+) T Cell Responses to Latent and Chronic Viral Infections but Not Heterologous Immune Graft-Reactive Responses.” In American Journal of Transplantation, 11:153–153. WILEY-BLACKWELL, 2011.

Scholars@Duke

Haridas, D., M. E. Wagener, A. D. Kirk, C. P. Larsen, and M. L. Ford. “Targeting the "Therapeutic Window" in Transplantation Via Differential Expression of LFA-1 on Pathogen vs. Allograft-Specific CD8(+) T Cells.” In American Journal of Transplantation, 11:474–474. WILEY-BLACKWELL, 2011.

Scholars@Duke

Xu, H., E. J. Kim, C. Larsen, and A. D. Kirk. “The Chemokines CXCL10 and CXCL11 Are Produced Directly by Renal Proximal Tubular Epithelial Cells in Response to Monocyte Derived TNF-alpha.” In American Journal of Transplantation, 11:233–233. WILEY-BLACKWELL, 2011.

Scholars@Duke

Mehta, A. K., P. L. Turner, H. Xu, L. L. Stempora, S. Nadler, A. D. Kirk, and C. P. Larsen. “The Effect of Costimulation Blockade with Belatacept on EBV Specific Immunity.” In American Journal of Transplantation, 11:346–346. WILEY-BLACKWELL, 2011.

Scholars@Duke

Freitas, A. M., A. J. Page, E. Dai, A. B. Farris, F. Leopardi, M. Song, E. Strobert, A. D. Kirk, and L. C. Cendales. “Vascularized Composite Allografts: Experience with Costimulation Blockade in Non-Human Primates.” In American Journal of Transplantation, 11:283–84. WILEY-BLACKWELL, 2011.

Scholars@Duke

Turner, A. P., V. O. Shaffer, K. Araki, C. Martens, P. L. Turner, S. Gangappa, M. L. Ford, R. Ahmed, A. D. Kirk, and C. P. Larsen. “Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.” Am J Transplant 11, no. 3 (March 2011): 613–18. https://doi.org/10.1111/j.1600-6143.2010.03407.x.

Full Text

Farris, A. B., J. Kong, C. Chisolm, H. M. Gebel, R. A. Bray, C. Cohen, D. J. Brat, J. H. Saltz, A. D. Kirk, and R. Hennigar. “HLA-DR Immunohistochemistry Quantitation in Renal Allograft Biopsies: Objective Discrimination of Rejection and Other Pathologic Processes.” In Laboratory Investigation, 91:344A-344A. NATURE PUBLISHING GROUP, 2011.

Scholars@Duke

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