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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin, Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Beus, J. M., M. Subramanian, A. K. Mehta, R. Eady, and A. D. Kirk. “CMV and EBV Viremia Occur as Independent Consequences of Immunosuppression.” In American Journal of Transplantation, 11:456–57. WILEY-BLACKWELL, 2011.

Scholars@Duke

Neujahr, D. C., A. Mohammed, O. Ulukpo, F. Fernandez, A. Pickens, E. C. Lawrence, K. C. Easley, S. D. Force, A. D. Kirk, and C. P. Larsen. “Cumulative Exposure to CD8 T Cells with Granzyme B Is Associated with Worse Lung Function Early after Lung Transplantation.” In American Journal of Transplantation, 11:395–395. WILEY-BLACKWELL, 2011.

Scholars@Duke

Neujahr, D. C., A. Mohammed, O. Ulukpo, E. C. Lawrence, F. Fernandez, A. Pickens, S. D. Force, C. P. Larsen, and A. D. Kirk. “Cumulative Exposure to Gamma Interferon Dependent Chemokines CXCL9 and CXCL10 Is Associated with Worse Function after Lung Transplantation.” In American Journal of Transplantation, 11:35–35. WILEY-BLACKWELL, 2011.

Scholars@Duke

Kitchens, W. H., A. D. Kirk, C. P. Larsen, and M. L. Ford. “Defining Populations of Pathogen-Elicited Donor-Specific Memory T Cells with Different Susceptibility to Costimulatory Blockade.” In American Journal of Transplantation, 11:153–153. WILEY-BLACKWELL, 2011.

Scholars@Duke

Cheeseman, J., E. Begley, S. Thomas, R. Eady, S. Monday, K. Bryant, R. Jones, et al. “Development of an Integrated Research Support Service for Clinical Transplant Research.” In American Journal of Transplantation, 11:241–42. WILEY-BLACKWELL, 2011.

Scholars@Duke

Kim, D., J. Beus, A. Gibby, L. Kean, A. D. Kirk, S. J. Knechtle, and J. Kwun. “Differential Effect of Costimulation Blockade on the Primary vs. Latent Infection in Minor Mismatched Skin Transplantation.” In American Journal of Transplantation, 11:523–523. WILEY-BLACKWELL, 2011.

Scholars@Duke

Srinivasan, S. K., A. J. Page, K. Singh, A. D. Kirk, C. P. Larsen, and L. S. Kean. “Identifying a Signature of Transplant Rejection in Non-Human Primates: Upregulation of CD95 Is a Site-Specific Marker That Strongly Correlates with Transplant Rejection.” In American Journal of Transplantation, 11:391–92. WILEY-BLACKWELL, 2011.

Scholars@Duke

Mehta, A. K., M. McCausland, J. Joseph, J. Cheeseman, J. Duraiswamy, P. Mulupuri, T. Gourley, et al. “Immunologic Ramifications of Depletion Induction Therapy and CMV Viremia in a Renal Transplant Cohort.” In American Journal of Transplantation, 11:389–389. WILEY-BLACKWELL, 2011.

Scholars@Duke

Kitchens, W. H., D. Haridas, A. D. Kirk, C. P. Larsen, and M. L. Ford. “Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8(+) Memory T Cells.” In American Journal of Transplantation, 11:477–477. WILEY-BLACKWELL, 2011.

Scholars@Duke

Kirk, A. D., S. Mead, H. Xu, A. Mehta, A. Guasch, J. Cheeseman, J. Joseph, et al. “Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy.” In American Journal of Transplantation, 11:45–45. WILEY-BLACKWELL, 2011.

Scholars@Duke

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