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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Reisman, Natalie M., Tamara L. Floyd, Maylene E. Wagener, Allan D. Kirk, Christian P. Larsen, and Mandy L. Ford. “LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.” Blood 118, no. 22 (November 24, 2011): 5851–61.

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Singh, Karnail, Natalia Kozyr, Linda Stempora, Allan D. Kirk, Christian P. Larsen, Bruce R. Blazar, and Leslie S. Kean. “Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells.” In Blood, 118:461–461. AMER SOC HEMATOLOGY, 2011.


Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos R. Abramowsky, Stuart J. Knechtle, and Allan D. Kirk. “PORTAL VENOUS FLOW ABNORMALITIES ARE PRESENT AND ARE ACCENTUATED AFTER ISCHEMIA REPERFUSION INJURY OF A STEATOTIC LIVER.” In Hepatology, 54:1168A-1168A. WILEY-BLACKWELL, 2011.


Jackson, J. A., E. J. Kim, B. Begley, J. Cheeseman, T. Harden, S. D. Perez, S. Thomas, B. Warshaw, and A. D. Kirk. “Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection.” Am J Transplant 11, no. 10 (October 2011): 2228–34.

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Safley, Susan A., Norma S. Kenyon, Dora M. Berman, Antonello Pileggi, Norman Kenyon, Hong Cui, Idelberto Badell, et al. “Function of microencapsulated adult porcine islet xenografts in streptozotocin-diabetic non-human primates.” In Xenotransplantation, 18:277–277. WILEY-BLACKWELL, 2011.


Bradley, J. A., W. M. Baldwin, A. Bingaman, C. Ellenrieder, H. M. Gebel, D. Glotz, and A. D. Kirk. “Antibody-mediated rejection--an ounce of prevention is worth a pound of cure.” Am J Transplant 11, no. 6 (June 2011): 1131–39.

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Thompson, P., K. Cardona, M. Russell, I. R. Badell, V. Shaffer, G. Korbutt, G. R. Rayat, et al. “CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.” Am J Transplant 11, no. 5 (May 2011): 947–57.

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Kim, E. J., J. Kwun, A. J. Page, F. Leopardi, A. C. Gibby, A. D. Kirk, and S. J. Knechtle. “A Non-Human Primate Model for Alloantibody Production after T Cell Depletion.” In American Journal of Transplantation, 11:369–369. WILEY-BLACKWELL, 2011.