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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Kirk, Allan D. “Where Has All the Science Gone?” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.

Scholars@Duke

Sam, Wai-Johnn, Christine E. Chamberlain, Su-Jun Lee, Joyce A. Goldstein, Douglas A. Hale, Roslyn B. Mannon, Allan D. Kirk, and Yuen Yi Hon. “A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.” Transplantation 92, no. 12 (December 27, 2011): 1342–47. https://doi.org/10.1097/TP.0b013e3182384ae2.

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Ferrer, Ivana R., Maylene E. Wagener, Minqing Song, Allan D. Kirk, Christian P. Larsen, and Mandy L. Ford. “Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.” Proc Natl Acad Sci U S A 108, no. 51 (December 20, 2011): 20701–6. https://doi.org/10.1073/pnas.1105500108.

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Mohammed, A., O. Ulukpo, E. C. Lawrence, F. Fernandez, A. Pickens, A. A. Gal, S. D. Force, et al. “Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.” Transplant Proc 43, no. 10 (December 2011): 3892–98. https://doi.org/10.1016/j.transproceed.2011.09.072.

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Thompson, P., I. R. Badell, M. Lowe, J. Cano, M. Song, F. Leopardi, J. Avila, et al. “Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.” Am J Transplant 11, no. 12 (December 2011): 2593–2602. https://doi.org/10.1111/j.1600-6143.2011.03720.x.

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Reisman, Natalie M., Tamara L. Floyd, Maylene E. Wagener, Allan D. Kirk, Christian P. Larsen, and Mandy L. Ford. “LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.” Blood 118, no. 22 (November 24, 2011): 5851–61. https://doi.org/10.1182/blood-2011-04-347252.

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Singh, Karnail, Natalia Kozyr, Linda Stempora, Allan D. Kirk, Christian P. Larsen, Bruce R. Blazar, and Leslie S. Kean. “Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells.” In Blood, 118:461–461. AMER SOC HEMATOLOGY, 2011.

Scholars@Duke

Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos R. Abramowsky, Stuart J. Knechtle, and Allan D. Kirk. “PORTAL VENOUS FLOW ABNORMALITIES ARE PRESENT AND ARE ACCENTUATED AFTER ISCHEMIA REPERFUSION INJURY OF A STEATOTIC LIVER.” In Hepatology, 54:1168A-1168A. WILEY-BLACKWELL, 2011.

Scholars@Duke

Jackson, J. A., E. J. Kim, B. Begley, J. Cheeseman, T. Harden, S. D. Perez, S. Thomas, B. Warshaw, and A. D. Kirk. “Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection.” Am J Transplant 11, no. 10 (October 2011): 2228–34. https://doi.org/10.1111/j.1600-6143.2011.03680.x.

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Safley, Susan A., Norma S. Kenyon, Dora M. Berman, Antonello Pileggi, Norman Kenyon, Hong Cui, Idelberto Badell, et al. “Function of microencapsulated adult porcine islet xenografts in streptozotocin-diabetic non-human primates.” In Xenotransplantation, 18:277–277. WILEY-BLACKWELL, 2011.

Scholars@Duke

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