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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Singh, K., L. Stempora, A. D. Kirk, C. P. Larsen, B. B. Blazar, and L. S. Kean. “Rhesus Macaque Natural CD4 Regulatory T Cells Exhibit Decreased Proliferation But Enhanced Suppression After Pulsing with Sirolimus.” In Biology of Blood and Marrow Transplantation, 18:S201–S201. Elsevier BV, 2012. https://doi.org/10.1016/j.bbmt.2011.12.523.

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Page, A., S. Srinivasan, K. Singh, M. Russell, K. Hamby, T. Deane, S. Sen, et al. “CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.” Am J Transplant 12, no. 1 (January 2012): 115–25. https://doi.org/10.1111/j.1600-6143.2011.03737.x.

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Kitchens, W. H., D. Haridas, M. E. Wagener, M. Song, A. D. Kirk, C. P. Larsen, and M. L. Ford. “Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.” Am J Transplant 12, no. 1 (January 2012): 69–80. https://doi.org/10.1111/j.1600-6143.2011.03762.x.

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Badell, I. R., P. W. Thompson, A. P. Turner, M. C. Russell, J. G. Avila, J. A. Cano, J. M. Robertson, et al. “Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.” Am J Transplant 12, no. 1 (January 2012): 126–35. https://doi.org/10.1111/j.1600-6143.2011.03736.x.

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Kirk, Allan D. “Where Has All the Science Gone?” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.

Scholars@Duke

Sam, Wai-Johnn, Christine E. Chamberlain, Su-Jun Lee, Joyce A. Goldstein, Douglas A. Hale, Roslyn B. Mannon, Allan D. Kirk, and Yuen Yi Hon. “A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.” Transplantation 92, no. 12 (December 27, 2011): 1342–47. https://doi.org/10.1097/TP.0b013e3182384ae2.

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Ferrer, Ivana R., Maylene E. Wagener, Minqing Song, Allan D. Kirk, Christian P. Larsen, and Mandy L. Ford. “Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.” Proc Natl Acad Sci U S A 108, no. 51 (December 20, 2011): 20701–6. https://doi.org/10.1073/pnas.1105500108.

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Mohammed, A., O. Ulukpo, E. C. Lawrence, F. Fernandez, A. Pickens, A. A. Gal, S. D. Force, et al. “Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.” Transplant Proc 43, no. 10 (December 2011): 3892–98. https://doi.org/10.1016/j.transproceed.2011.09.072.

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Thompson, P., I. R. Badell, M. Lowe, J. Cano, M. Song, F. Leopardi, J. Avila, et al. “Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.” Am J Transplant 11, no. 12 (December 2011): 2593–2602. https://doi.org/10.1111/j.1600-6143.2011.03720.x.

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Reisman, Natalie M., Tamara L. Floyd, Maylene E. Wagener, Allan D. Kirk, Christian P. Larsen, and Mandy L. Ford. “LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.” Blood 118, no. 22 (November 24, 2011): 5851–61. https://doi.org/10.1182/blood-2011-04-347252.

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