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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Freitas, A. M., A. B. Farris, F. Leopardi, M. Song, E. Strobert, A. D. Kirk, and L. C. Cendales. “Costimulation Blockade Based Regimens Prolong Graft Survival of Vascularized Composite Allografts in Non-Human Primates.” In American Journal of Transplantation, 12:33–33. WILEY-BLACKWELL, 2012.

Scholars@Duke

Kwun, J., B. Oh, A. Gibby, R. Ruhil, V. Lu, O. P. Bulut, M. Song, et al. “Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:278–278. WILEY-BLACKWELL, 2012.

Scholars@Duke

Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, V. Lu, D. Kim, et al. “Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:463–463. WILEY-BLACKWELL, 2012.

Scholars@Duke

Turgeon, Nicole A., Sebastian Perez, Max Mondestin, S Scott Davis, Edward Lin, Sudha Tata, Allan D. Kirk, Christian P. Larsen, Thomas C. Pearson, and John F. Sweeney. “The impact of renal function on outcomes of bariatric surgery.” J Am Soc Nephrol 23, no. 5 (May 2012): 885–94. https://doi.org/10.1681/ASN.2011050476.

Full Text

Srinivasan, S. K., H. L. Triemer, and A. D. Kirk. “Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade.” In Immunotherapy in Transplantation: Principles and Practice, 407–28, 2012. https://doi.org/10.1002/9781444355628.ch28.

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Neujahr, D. C., S. D. Perez, A. Mohammed, O. Ulukpo, E. C. Lawrence, F. Fernandez, A. Pickens, et al. “Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant.” Am J Transplant 12, no. 2 (February 2012): 438–46. https://doi.org/10.1111/j.1600-6143.2011.03857.x.

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Singh, K., L. Stempora, A. D. Kirk, C. P. Larsen, B. B. Blazar, and L. S. Kean. “Rhesus Macaque Natural CD4 Regulatory T Cells Exhibit Decreased Proliferation But Enhanced Suppression After Pulsing with Sirolimus.” In Biology of Blood and Marrow Transplantation, 18:S201–S201. Elsevier BV, 2012. https://doi.org/10.1016/j.bbmt.2011.12.523.

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Page, A., S. Srinivasan, K. Singh, M. Russell, K. Hamby, T. Deane, S. Sen, et al. “CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.” Am J Transplant 12, no. 1 (January 2012): 115–25. https://doi.org/10.1111/j.1600-6143.2011.03737.x.

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Kitchens, W. H., D. Haridas, M. E. Wagener, M. Song, A. D. Kirk, C. P. Larsen, and M. L. Ford. “Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.” Am J Transplant 12, no. 1 (January 2012): 69–80. https://doi.org/10.1111/j.1600-6143.2011.03762.x.

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Badell, I. R., P. W. Thompson, A. P. Turner, M. C. Russell, J. G. Avila, J. A. Cano, J. M. Robertson, et al. “Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.” Am J Transplant 12, no. 1 (January 2012): 126–35. https://doi.org/10.1111/j.1600-6143.2011.03736.x.

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