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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Krummey, S. M., J. A. Cheeseman, J. A. Conger, P. S. Jang, A. K. Mehta, A. D. Kirk, C. P. Larsen, and M. L. Ford. “High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.” Am J Transplant 14, no. 3 (March 2014): 607–14.

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Rosenblum, Joshua M., and Allan D. Kirk. “Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.” Immunol Rev 258, no. 1 (March 2014): 167–82.

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Xu, H., S. D. Perez, J. Cheeseman, A. K. Mehta, and A. D. Kirk. “The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation.” Am J Transplant 14, no. 2 (February 2014): 319–32.

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Kim, E. J., J. Kwun, A. C. Gibby, J. J. Hong, A. B. Farris, N. N. Iwakoshi, F. Villinger, A. D. Kirk, and S. J. Knechtle. “Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.” Am J Transplant 14, no. 1 (January 2014): 59–69.

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Lo, D. J., A. B. Farris, M. Song, F. Leopardi, D. J. Anderson, E. A. Strobert, S. Ramakrishnan, et al. “Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates.” Am J Transplant 13, no. 12 (December 2013): 3085–93.

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Koura, Divya T., John T. Horan, Amelia A. Langston, Muna Qayed, Aneesh Mehta, Hanna J. Khoury, R Donald Harvey, et al. “In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial.” Biol Blood Marrow Transplant 19, no. 11 (November 2013): 1638–49.

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Pena, Juan A., Lauren Titus, Jennifer Jackson, Allan D. Kirk, and Jennifer L. Gooch. “Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem.” Transplantation 96, no. 3 (August 15, 2013): 239–44.

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O’Leary, J. G., H. M. Gebel, R. Ruiz, R. A. Bray, J. D. Marr, X. J. Zhou, S. M. Shiller, B. M. Susskind, A. D. Kirk, and G. B. Klintmalm. “Class II alloantibody and mortality in simultaneous liver-kidney transplantation.” Am J Transplant 13, no. 4 (April 2013): 954–60.

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