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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Shaw, Brian I., Jaclyn R. Espinosa, Linda Stempora, Allison Miller, Bartley Adams, and Allan D. Kirk. “Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression.” J Immunol 206, no. 7 (April 1, 2021): 1668–76. https://doi.org/10.4049/jimmunol.2000736.

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David, Emeraghi, Minghua Zhu, Braden C. Bennett, Daniel Cheng, Paul Schroder, Amanda Nichols, Nancie MacIver, Allan D. Kirk, William Parker, and Eileen T. Chambers. “Undernutrition and Hypoleptinemia Modulate Alloimmunity and CMV-specific Viral Immunity in Transplantation.” Transplantation, March 10, 2021. https://doi.org/10.1097/TP.0000000000003743.

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Moris, Dimitrios, Jun Wang, Maria Angelica Selim, Mingqing Song, Linda Stempora, William Parker, Allan D. Kirk, and Linda C. Cendales. “Vascularized composite allotransplants as a mechanistic model for allograft rejection - an experimental study.” Transpl Int 34, no. 3 (March 2021): 572–84. https://doi.org/10.1111/tri.13820.

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Song, Mingqing, Zachary W. Fitch, Kannan P. Samy, Benjamin M. Martin, Qimeng Gao, Robert Patrick Davis, Francis V. Leopardi, et al. “Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation.” Xenotransplantation, February 22, 2021, e12680. https://doi.org/10.1111/xen.12680.

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Shaw, Brian I., Hui-Jie Lee, Cliburn Chan, Robert Ettenger, Paul Grimm, Meghan Pearl, Elaine F. Reed, et al. “Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation.” Am J Transplant 21, no. 2 (February 2021): 766–75. https://doi.org/10.1111/ajt.16263.

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Schmitz, Robin, Zachary W. Fitch, He Xu, Ada Ghali, Aneesh K. Mehta, Antonio Guasch, and Allan D. Kirk. “Kidney transplantation using alemtuzumab, belatacept, and sirolimus: Five-year follow-up.” Am J Transplant 20, no. 12 (December 2020): 3609–19. https://doi.org/10.1111/ajt.16121.

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Calabrese, Leonard H., Roberto Caporali, Christian U. Blank, and Allan D. Kirk. “Modulating the wayward T cell: New horizons with immune checkpoint inhibitor treatments in autoimmunity, transplant, and cancer.” J Autoimmun 115 (December 2020): 102546. https://doi.org/10.1016/j.jaut.2020.102546.

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Kirk, Allan D., Andrew B. Adams, Antoine Durrbach, Mandy L. Ford, David A. Hildeman, Christian P. Larsen, Flavio Vincenti, David Wojciechowski, and E Steve Woodle. “Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients.” Am J Transplant, October 31, 2020. https://doi.org/10.1111/ajt.16386.

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Vicente, Diego, Seth Schobel, Simone Anfossi, Hannah Hensman, Felipe Lisboa, Thomas Davis, Christopher John Dente, Allan Douglas Kirk, George Calin, and Eric Andrew Elster. “Characterization of Cellular and Viral MicroRNA in Polytrauma Patients.” In Journal of the American College of Surgeons, 231:E59–E59, 2020.

Scholars@Duke

Pages