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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Samy, KP, Davis, RP, Gao, Q, Martin, BM, Song, M, Cano, J, Farris, AB, McDonald, A, Gall, EK, Dove, CR, Leopardi, FV, How, T, Williams, KD, Devi, GR, Collins, BH, and Kirk, AD. "Early barriers to neonatal porcine islet engraftment in a dual transplant model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 18, no. 4 (April 2018): 998-1006.

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Song, M, Mulvihill, MS, Williams, KD, Collins, BH, and Kirk, AD. "Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque." Journal of medical primatology 47, no. 1 (February 2018): 81-84.

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Lamanna, JJ, Gutierrez, J, Espinosa, JR, Wagner, J, Urquia, LN, Moreton, C, Victor Hurtig, C, Tora, M, Kirk, AD, Federici, T, and Boulis, NM. "Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord." Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 48 (February 2018): 173-180.

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Xu, H, Bendersky, VA, Brennan, TV, Espinosa, JR, and Kirk, AD. "IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 14, 2017).

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Adams, AB, Goldstein, J, Garrett, C, Zhang, R, Patzer, RE, Newell, KA, Turgeon, NA, Chami, AS, Guasch, A, Kirk, AD, Pastan, SO, Pearson, TC, and Larsen, CP. "Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 11 (November 2017): 2922-2936.

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Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119.

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Dente, CJ, Bradley, M, Schobel, S, Gaucher, B, Buchman, T, Kirk, AD, and Elster, E. "Towards precision medicine: Accurate predictive modeling of infectious complications in combat casualties." The journal of trauma and acute care surgery 83, no. 4 (October 2017): 609-616.

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Ettenger, R, Chin, H, Kesler, K, Bridges, N, Grimm, P, Reed, EF, Sarwal, M, Sibley, R, Tsai, E, Warshaw, B, and Kirk, AD. "Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 6 (June 2017): 1549-1562.

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Samy, KP, Anderson, DJ, Lo, DJ, Mulvihill, MS, Song, M, Farris, AB, Parker, BS, MacDonald, AL, Lu, C, Springer, TA, Kachlany, SC, Reimann, KA, How, T, Leopardi, FV, Franke, KS, Williams, KD, Collins, BH, and Kirk, AD. "Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 5 (May 2017): 1193-1203.

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Modena, BD, Milam, R, Harrison, F, Cheeseman, JA, Abecassis, MM, Friedewald, JJ, Kirk, AD, and Salomon, DR. "Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 3 (March 2017): 712-723.

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