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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Levitsky, Josh, Bryna E. Burrell, Sai Kanaparthi, Laurence A. Turka, Sunil Kurian, Alberto Sanchez-Fueyo, Juan J. Lozano, et al. “Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus.” Hepatology 72, no. 2 (August 2020): 569–83. https://doi.org/10.1002/hep.31036.

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Bradley, Matthew, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G. Buchman, and Eric Elster. “Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.” World J Surg 44, no. 7 (July 2020): 2255–62. https://doi.org/10.1007/s00268-019-05294-3.

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Gerardo, C. J., E. Silvius, S. Schobel, J. Eppensteiner, L. McGowan, A. T. Limkakeng, A. D. Kirk, and E. A. Elster. “ASSOCIATION OF A CYTOKINE RESPONSE NETWORK WITH FUNCTIONAL RECOVERY FROM SNAKEBITE ENVENOMING.” In Toxicon, 182:S15–16, 2020.

Scholars@Duke

Bradley, Matthew, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G. Buchman, and Eric Elster. “Correction to: Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.” World J Surg 44, no. 7 (July 2020): 2263. https://doi.org/10.1007/s00268-020-05520-3.

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Muñoz, Beau, Seth A. Schobel, Felipe A. Lisboa, Vivek Khatri, Scott F. Grey, Christopher J. Dente, Allan D. Kirk, Timothy Buchman, and Eric A. Elster. “Clinical risk factors and inflammatory biomarkers of post-traumatic acute kidney injury in combat patients.” Surgery, June 27, 2020. https://doi.org/10.1016/j.surg.2020.04.064.

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Schmitz, Robin, Zachary W. Fitch, He Xu, Ada Ghali, Aneesh K. Mehta, Antonio Guasch, and Allan D. Kirk. “Kidney transplantation using alemtuzumab, belatacept, and sirolimus: Five-year follow-up.” Am J Transplant, June 8, 2020. https://doi.org/10.1111/ajt.16121.

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Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020). https://doi.org/10.1172/jci.insight.129983.

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Lee, Frances T., Anil Dangi, Sahil Shah, Melanie Burnette, Yong-Guang Yang, Allan D. Kirk, Bernhard J. Hering, Stephen D. Miller, and Xunrong Luo. “Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells.” Am J Transplant 20, no. 6 (June 2020): 1538–50. https://doi.org/10.1111/ajt.15763.

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Atia, Andrew, Dimitrios Moris, MacKenzie McRae, Mingqing Song, Linda Stempora, Francis Leopardi, Kyha Williams, et al. “Th17 cell inhibition in a costimulation blockade-based regimen for vascularized composite allotransplantation using a nonhuman primate model.” Transpl Int, April 11, 2020. https://doi.org/10.1111/tri.13612.

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Aronson, Solomon, Gavin Martin, Padma Gulur, Mike E. Lipkin, Sandhya A. Lagoo-Deenadayalan, Christopher R. Mantyh, David E. Attarian, Joseph P. Mathew, and Allan D. Kirk. “Preoperative Optimization: A Continued Call to Action.” Anesth Analg 130, no. 4 (April 2020): 808–10. https://doi.org/10.1213/ANE.0000000000004492.

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