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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris Iii, Maragatha Kuchibhatla, Joseph W. Turek, Stuart Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implementation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight, April 30, 2020. https://doi.org/10.1172/jci.insight.129983.

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Bradley, Matthew, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G. Buchman, and Eric Elster. “Correction to: Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.” World J Surg, April 19, 2020. https://doi.org/10.1007/s00268-020-05520-3.

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Atia, Andrew, Dimitrios Moris, MacKenzie McRae, Mingqing Song, Linda Stempora, Francis Leopardi, Kyha Williams, et al. “Th17 cell inhibition in a costimulation blockade-based regimen for vascularized composite allotransplantation using a nonhuman primate model.” Transpl Int, April 11, 2020. https://doi.org/10.1111/tri.13612.

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Aronson, Solomon, Gavin Martin, Padma Gulur, Mike E. Lipkin, Sandhya A. Lagoo-Deenadayalan, Christopher R. Mantyh, David E. Attarian, Joseph P. Mathew, and Allan D. Kirk. “Preoperative Optimization: A Continued Call to Action.” Anesth Analg 130, no. 4 (April 2020): 808–10. https://doi.org/10.1213/ANE.0000000000004492.

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Aronson, Solomon, Sutton Murray, Gavin Martin, Jeanna Blitz, Timothy Crittenden, Mike E. Lipkin, Christopher R. Mantyh, et al. “Roadmap for Transforming Preoperative Assessment to Preoperative Optimization.” Anesth Analg 130, no. 4 (April 2020): 811–19. https://doi.org/10.1213/ANE.0000000000004571.

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Corey, Kristin M., Joshua Helmkamp, Morgan Simons, Lesley Curtis, Keith Marsolo, Suresh Balu, Michael Gao, et al. “Assessing Quality of Surgical Real-World Data from an Automated Electronic Health Record Pipeline.” J Am Coll Surg 230, no. 3 (March 2020): 295-305.e12. https://doi.org/10.1016/j.jamcollsurg.2019.12.005.

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Xu, He, Aneesh K. Mehta, Qimeng Gao, Hui-Jie Lee, Ada Ghali, Antonio Guasch, and Allan D. Kirk. “B cell reconstitution following alemtuzumab induction under a belatacept-based maintenance regimen.” Am J Transplant 20, no. 3 (March 2020): 653–62. https://doi.org/10.1111/ajt.15639.

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Dente, Christopher John, Edda Styrmisdottir, Audrey Shi, Seth Schobel, Vivek Khatri, Benjamin K. Potter, Jonathan A. Forsberg, Timothy Buchman, Allan D. Kirk, and Eric Elster. “Driving biology: The effect of standardized wound management on wound biomarker profiles.” J Trauma Acute Care Surg 88, no. 3 (March 2020): 379–89. https://doi.org/10.1097/TA.0000000000002568.

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Blew, Kathryn H., Annabelle Chua, John Foreman, Rasheed Gbadegesin, Annette Jackson, Shashi Nagaraj, Rebecca Sadun, Del Wigfall, Allan D. Kirk, and Eileen T. Chambers. “Tailored use of belatacept in adolescent kidney transplantation.” Am J Transplant 20, no. 3 (March 2020): 884–88. https://doi.org/10.1111/ajt.15611.

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Lee, Frances T., Anil Dangi, Sahil Shah, Melanie Burnette, Yong-Guang Yang, Allan D. Kirk, Bernhard J. Hering, Stephen D. Miller, and Xunrong Luo. “Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells.” Am J Transplant, December 28, 2019. https://doi.org/10.1111/ajt.15763.

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