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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Li, Shu, He Xu, and Allan D. Kirk. “Modulation of Xenogeneic T-cell Proliferation by B7 and mTOR Blockade of T Cells and Porcine Endothelial Cells.” Transplantation 106, no. 5 (May 1, 2022): 950–62. https://doi.org/10.1097/TP.0000000000003920.

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Li, Shu, He Xu, Mingqing Song, Brian I. Shaw, Qi-Jing Li, and Allan D. Kirk. “IFI16-STING-NF-κB signaling controls exogenous mitochondrion-induced endothelial activation.” Am J Transplant, March 24, 2022. https://doi.org/10.1111/ajt.17034.

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Walsh, Evan S., Tammy S. Tollison, Hayden N. Brochu, Brian I. Shaw, Kayleigh R. Diveley, Hsuan Chou, Lynn Law, Allan D. Kirk, Michael Gale, and Xinxia Peng. “Single-Cell-Based High-Throughput Ig and TCR Repertoire Sequencing Analysis in Rhesus Macaques.” J Immunol 208, no. 3 (February 1, 2022): 762–71. https://doi.org/10.4049/jimmunol.2100824.

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Martin, Gavin, Clif Flintom, Kate Ulrich, and Allan D. Kirk. “The Accreditation Council for Graduate Medical Education Special Report on Clinical Learners in Procedural Environments: Several Elephants in a Very Small Room.” Anesthesiology 136, no. 2 (February 1, 2022): 265–67. https://doi.org/10.1097/ALN.0000000000004059.

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Vicente, Diego, Seth A. Schobel, Simone Anfossi, Hannah Hensman, Felipe Lisboa, Henry Robertson, Vivek Khatri, et al. “Viral Micro-RNAs Are Detected in the Early Systemic Response to Injury and Are Associated With Outcomes in Polytrauma Patients.” Crit Care Med 50, no. 2 (February 1, 2022): 296–306. https://doi.org/10.1097/CCM.0000000000005181.

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Bradley, Matthew, A. Shi, V. Khatri, S. Schobel, E. Silvius, A. Kirk, T. Buchman, J. Oh, and E. Elster. “Prediction of venous thromboembolism using clinical and serum biomarker data from a military cohort of trauma patients.” Bmj Mil Health 167, no. 6 (December 2021): 402–7. https://doi.org/10.1136/bmjmilitary-2019-001393.

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David, Emeraghi, Minghua Zhu, Braden C. Bennett, Daniel Cheng, Paul Schroder, Amanda Nichols, William Parker, Allan D. Kirk, Nancie MacIver, and Eileen T. Chambers. “Undernutrition and Hypoleptinemia Modulate Alloimmunity and CMV-specific Viral Immunity in Transplantation.” Transplantation 105, no. 12 (December 1, 2021): 2554–63. https://doi.org/10.1097/TP.0000000000003743.

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Gao, Qimeng, Robert Davis, Zachary Fitch, Michael Mulvihill, Brian Ezekian, Paul Schroder, Robin Schmitz, et al. “Anti-thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival.” Xenotransplantation 28, no. 6 (November 2021): e12713. https://doi.org/10.1111/xen.12713.

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Dente, Christopher J., Michael J. Mina, Bryan C. Morse, Hannah Hensman, Seth Schobel, Rondi B. Gelbard, Arnaud Belard, Timothy G. Buchman, Allan D. Kirk, and Eric A. Elster. “Predicting the need for massive transfusion: Prospective validation of a smartphone-based clinical decision support tool.” Surgery 170, no. 5 (November 2021): 1574–80. https://doi.org/10.1016/j.surg.2021.04.034.

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