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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

David, Emeraghi, Minghua Zhu, Braden C. Bennett, Daniel Cheng, Paul Schroder, Amanda Nichols, William Parker, Allan D. Kirk, Nancie MacIver, and Eileen T. Chambers. “Undernutrition and Hypoleptinemia Modulate Alloimmunity and CMV-specific Viral Immunity in Transplantation.” Transplantation 105, no. 12 (December 1, 2021): 2554–63. https://doi.org/10.1097/TP.0000000000003743.

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Dente, Christopher J., Michael J. Mina, Bryan C. Morse, Hannah Hensman, Seth Schobel, Rondi B. Gelbard, Arnaud Belard, Timothy G. Buchman, Allan D. Kirk, and Eric A. Elster. “Predicting the need for massive transfusion: Prospective validation of a smartphone-based clinical decision support tool.” Surgery 170, no. 5 (November 2021): 1574–80. https://doi.org/10.1016/j.surg.2021.04.034.

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Xu, He, Hui-Jie Lee, Robin Schmitz, Brian I. Shaw, Shu Li, and Allan D. Kirk. “Age-related effects on thymic output and homeostatic T cell expansion following depletional induction in renal transplant recipients.” Am J Transplant 21, no. 9 (September 2021): 3163–74. https://doi.org/10.1111/ajt.16625.

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Breslin, Adam W., Alexander T. Limkakeng, Elizabeth Silvius, Catherine A. Staton, Chandra Almond, Mary-Beth Joshi, Bartley Adams, et al. “Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.” Clin Transl Sci 14, no. 5 (September 2021): 1791–98. https://doi.org/10.1111/cts.13022.

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Shaw, Brian I., Robin Schmitz, Walter J. Flores, Diogo M. Magnani, Jie Li, Mingqing Song, and Allan D. Kirk. “A comparative study of human-and rhesus-specific antithymocyte globulins in Rhesus macaques.” Clin Transplant 35, no. 8 (August 2021): e14369. https://doi.org/10.1111/ctr.14369.

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Vicente, Diego, Seth A. Schobel, Simone Anfossi, Hannah Hensman, Felipe Lisboa, Henry Robertson, Vivek Khatri, et al. “Viral Micro-RNAs Are Detected in the Early Systemic Response to Injury and Are Associated With Outcomes in Polytrauma Patients.” Crit Care Med, July 2, 2021. https://doi.org/10.1097/CCM.0000000000005181.

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Song, Mingqing, Zachary W. Fitch, Kannan P. Samy, Benjamin M. Martin, Qimeng Gao, Robert Patrick Davis, Francis V. Leopardi, et al. “Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation.” Xenotransplantation 28, no. 3 (May 2021): e12680. https://doi.org/10.1111/xen.12680.

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Kirk, Allan D., Andrew B. Adams, Antoine Durrbach, Mandy L. Ford, David A. Hildeman, Christian P. Larsen, Flavio Vincenti, David Wojciechowski, and E Steve Woodle. “Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients.” Am J Transplant 21, no. 5 (May 2021): 1691–98. https://doi.org/10.1111/ajt.16386.

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Shaw, Brian I., Jaclyn R. Espinosa, Linda Stempora, Allison Miller, Bartley Adams, and Allan D. Kirk. “Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression.” J Immunol 206, no. 7 (April 1, 2021): 1668–76. https://doi.org/10.4049/jimmunol.2000736.

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