Skip to main content

Mechanical Support for Heart and Lung Disease Research

Photo of Mani Ali Daneshmand, MD

Mani Ali Daneshmand, MD

Office: Dept of Surgery, Durham, NC 27710
Campus Mail: Box 3443 Med Ctr, Durham, NC 27710
Phone: 919-681-5925

Scientific Focus

Duke researchers, including Mani A. Daneshmand, MD, are investigating the use of mechanical circulatory support for individuals with acute treatable conditions causing lung or heart failure. Duke has developed multiple research programs in physiology, immunology, vascular biology, hematology, cellular and molecular biology, focusing on the effect of mechanical circulatory support systems.

Dr. Daneshmand and co-investigators seek to study important clinical questions regarding variables that influence outcomes for therapies for advanced heart or lung failure and how mechanical support is best applied in various clinical settings. We've used large databases and registries such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), and the Nationwide Inpatient Sample (NIS) to evaluate cost-effectiveness, safety, and quality of life for mechanical circulatory support therapies.

We've reported our research in national and international forums including the International Society for Heart and Lung Transplantation (ISHLT) and the Society of Thoracic Surgeons (STS) annual meeting. Collaborating postdoctoral fellows include Anthony Castleberry, MD, MSCi; Matthew Schechter, MD; James Meza, MD; Michael Mulvihill, MD; and Muath Bishawi, MD.

Latest Publications

Fierro, MA, Daneshmand, MA, and Bartz, RR. "Perioperative Management of the Adult Patient on Venovenous Extracorporeal Membrane Oxygenation Requiring Noncardiac Surgery." Anesthesiology 128, no. 1 (January 2018): 181-201. (Review)

Full Text

Barac, YD, Alwair, H, Kong, DF, Patel, CB, Daneshmand, MA, Milano, CA, and Schroder, JN. "Migration of Intraaortic Balloon Pump Placed Via the Axillary Artery." The Journal of invasive cardiology 30, no. 1 (January 2018): E11-.


Nicoara, A, Ruffin, D, Cooter, M, Patel, CB, Thompson, A, Schroder, JN, Daneshmand, MA, Hernandez, AF, Rogers, JG, Podgoreanu, MV, Swaminathan, M, Kretzer, A, Stafford-Smith, M, Milano, CA, and Bartz, RR. "Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 14, 2017).

Full Text

Mulvihill, MS, Joseph, JT, Daneshmand, MA, Patel, CB, Milano, CA, and Schroder, JN. "Usefulness of 2 centrifugal ventricular assist devices in a total artificial heart configuration: A preliminary report." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 36, no. 11 (November 2017): 1266-1268. (Letter)

Full Text