Overview
Our research program focuses on modulating the pre-formed alloimmune response to donor antigen in sensitized recipients. Advances in organ transplantation, B cell immunology, and hematologic malignancy research led me to expand my goals to include identifying strategies for both desensitization and treating AMR by targeting components of the post-transplant humoral immune response. In addition, we applied the knowledge gained by studying the alloimmune response to xenotransplantation, with the goal of improving long-term outcomes of kidney xenotransplantation by decreasing xeno-reactive antibodies as well as alleviating post-xenotransplant AMR.
The six primary research interests of TIRTL are,
- Pre-clinical models for organ transplantation
- Desensitization strategies – Preclinical/Clinical
- Xenotransplantation
- Antibody-mediated rejection (AMR) treatment
- Optimal immunosuppression
- Tolerance
Lab Members
Current Lab Members
Shengli Song, PhD (Faculty)
Instructor of Surgery, 2022.4 – Present
Elinor Mannon, MD, PhD
Post-doctoral Fellow (Duke Surgery PGY3), 2026.7 — Present
Janghoon Yoon, BS
Project/Lab manager, 2015.6 – Present
Rafaella Belloni, BS
Research Technician, 2022.6 – Present
Zheng Chen, BS, MMSc
Research Analyst, 2024.1 – Present
Tao Wang
Research Analyst, 2025.6-Present
Airong Wan
Research Analyst, 2025,6-Present
Mingqing Song, PhD
Research Analyst, 2025.6-Present
Allison Miller, BS
Lab manager, 2026. 6 - Present
David Woo, MS
Graduate Student (PhD course), 2025.6 - Present
Zishen Li (Duke U, undergraduate Student)
Summer intern, 2024. 6 – 2024. 8
Volunteer undergrad student, 2024.8 – Present
Mei-Mei Hu (Duke U, undergraduate Student)
Summer intern, 2025.6-2025.8
Volunteer undergrad student, 2025.8 - Present
Jacqueline Kwun (Duke U, undergraduate Student)
Summer intern, 2025.6-2026.8
Hongbeom Kim, MD, PhD
Visiting Scholar (Samsung Medical Center, Korea), 2026. 9 - Present
Hyung Soon Lee, MD, PhD
Visiting Scholar (National Health Insurance service, Ilsan Hospital, Korea), 2025.8 - 2026.7
Davide Schiliro, MD
Post-doctoral Fellow, 2023. 5 – 2026.6
Sang Hyun Shin, MD, PhD
Visiting Scholar (Samsung Medical Center, South Korea), 2024.8 - 2025.7
Alessandro Martinino, MD
Post-doctoral Fellow, 2023. 11 – 2025.6
Nagham Bazzi, MD
Post-doctoral Fellow, 2024.1 – 2025.6
Matthew Tunbridge, MD
Post-doctoral Fellow, PhD candidate, 2023.8 – 2026.4
Emma Fatzaun, BS
Research Technician, 2023.8 – 2025.7
Angela Park, BS
Research Technician, 2023.1-2025.4
Meghan Hu, BS (MS2)
Duke Medical Student (DUMC), 2023.10-2025.6(2023 Bollinger Scholarship recipients)
Kyo Won Lee, MD, PhD
Visiting Scholar (Samsung Medical Center, South Korea), 2023.8- 2024.7
Min Jung Kim, MD, PhD
Visiting Scholar (Seoul Medical Center, South Korea), 2023.8 – 2024.7
Joseph Ladowski, MD, PhD (PGY3)
Duke research Resident (DUMC), 2022.7-2024.6
Allie Schwalb, BS (MS2)
Duke Medical Student (DUMC), 2023.9-2024.6 (2023 ASTS Presidential Student Mentor Grant recipients)
Imran Anwar, MD (PGY4)
Duke Research Resident (DUMC), 2021.7-Present
Isabel DeLaura, BS (MS2)
Duke Medical Student (DUMC), 2021.9-Present (2022 ASTS Presidential Student Mentor Grant recipients)
Miriam Manook, MD, PhD
Visiting Research Resident (Kings College, UK), 9/2015-8/2016
Visiting Research Resident (Kings College, UK), 9/2019-8/2021
Currently at the University of Cambridge, UK
Danae Olaso, MD
Duke Medical Student (DUMC), 6/2019-8-2019 (2019 ASTS Presidential Student Mentor Grant recipients)
Duke Medical Student (DUMC), 10/2020-6/2021 (Bollinger Scholarship)
Currently at UC San Diego (General Surgery Resident)
Robert Baldi, BS
Research Technician, 2021 - 2022
Yeeun Bae, BS
Research Technician, 2020-2021
Currently, PhD Student at Virginia Tech, Blacksburg, VA
Robin Schmitz, MD
Duke Research Resident (DUMC), 7/2018-6/2020
Currently at the University of Pittsburg (Fellow – Surgical Oncology)
Zachery Fitch, MD
Duke Research Resident (DUMC), 7/2018-6/2020
Ashley Choi, MD
Duke Medical Student (DUMC), 7/2018-4/2020
Currently at Stanford University, CA (Surgery resident)
Paul Schroder, MD, PhD
Duke Research Resident (DUMC), 7/2017-6/2019
Currently at the University of Wisconsin-Madison (Transplant Fellow)
Kyle Freischlag, MD
2nd year Medical Student (DUMC), 9/2016-6/2018
Currently at the University of Iowa (Surgery resident)
Brian Ezekian, MD
Duke Research Resident (DUMC), 7/2016-6/2018
Currently at the University of Toronto (Transplant Fellow)
Jae Berm Park, MD, PhD
Visiting Scholar, 7/2015-7/2016
Currently at Samsung Medical Center (Division Chair), Seoul, South Korea
Christopher Burghuber, MD
Visiting Research Resident (Medical University of Vienna, Austria), 6/2013-5/2015
Currently, Vascular Surgeon at the Medical University of Vienna, Austria
Eugenia Page, MD
Emory research Resident, 7/2010-6/2012
Emory research Resident, 7/2014-1/2015
Currently at Atlanta Plastic & Reconstructive Specialists, Atlanta, GA
Andrew Page, MD
Emory research Resident, 7/2008-6/2010
Currently at Piedmont Hospital, Atlanta, GA
Silke V. Niederhaus, MD
Research Resident (University of Wisconsin-Madison), 6/2005-6/2007 (2006-2008 ASTS Jon Fryer Resident Scientist Scholarship recipient)
Currently at the University of Maryland School of Medicine, Baltimore, MD
Wasim Dar, MD, PhD
Research Resident/PhD (University of Wisconsin-Madison), 2002-2007
Currently at Hartford HealthCare Medical Group, Hartford Hospital Transplant & Comprehensive Liver Center, Hartford, CT
Andrea Proneth, MD
Visiting Medical Student from University Hospital Regensburg, Regensburg, Germany, 2004-2005
Beate Exner, MD
Visiting Resident from University Hospital Regensburg, Regensburg, Germany, 2004-2005
Drew Roenneburg, PA-C
Laboratory histologist, 2003 – 2007
Currently at SSM Health, Madison, WI
Turan Kanmaz, MD
Visiting Scholar/Research fellow (University of Wisconsin-Madison), 2002-2003
Currently at Koç University Hospital, Zeytinburnu/İstanbul, Türkiye
Debora Bloom, PhD
Post-doc Fellow (University of Wisconsin-Madison), 2002-2007
Currently at Covance (Scientific Specialist)
Zen Davis, PhD
Research associate (University of Wisconsin-Madison), 2002 - 2007
Retired
Huaizhong Hu, PhD
Faculty/Assistant Professor (University of Wisconsin-Madison)
Currently, VP of Preclinical Development at CANbridge Life Science, Beijing, China
Ping Feng, PhD
Post-doc Fellow (University of Wisconsin-Madison), 2001-2003
Currently, Chief Medical Officer at Medbanks Network Technology, Shanghai, China
Yinching Dong, BS
Lab Technician, ~2007
Presumed Retired
Jacqueline Schultz, BS
Lab Technician/histologist, ~2003
Retired
John Fechner, MS
Lab manager, ~2007
Currently at University of Wisconsin-Madison
Edward Geissler, PhD
PhD Student
Currently, Professor of Experimental Surgery, University of Regensburg, Germany
Yuan Zhai, PhD
PhD Student, 1992-1998
Currently, Professor at Department of Surgery, Medical University of South Carolina
Jacqueline Kwun (Duke U, undergraduate Student)
Summer intern, 2026.6-2026.8
Emma Shin (University of North Carolina, undergraduate student)
Summer intern, 2025.6 – 2025.8
Summer intern, 2026.6 – 2026.8
Mei-Mei Hu (Duke U, undergraduate Student)
Summer intern, 2025.6-2025.8
Volunteer undergrad student, 2025.8 – Present
Independent study (Spring 2025)
Zishen Li (Duke U, undergraduate Student)
Summer intern, 2024. 6 – 2024. 8
Volunteer undergrad student, 2024.8 – Present
Independent Study (Spring 2024, Spring 2025)
Ryan Spangler
Volunteer undergrad student (Duke University). 2022.10-2023.1; Independent Study (Project Term: Spring 2023). 2023.1-2023. 5
Simon Keating
Summer Research Intern (Gordon College), 6/2023-8/2023
Ryan Spangler
Summer Research Intern (Duke University), 6/2023-8/2023
Joshua Sun
Summer Research Intern (Baylor University), 6/2022-8/2022
Jenny Hong
Summer high school student intern (NC math and science), 7/2019
Eunseo Maeng
Summer Research Intern (Gordon College), 6/2019-8/2019
Tochi Anioke
Summer Research Intern (Gordon College), 6/2019-8/2019
Yeeun Bae
Summer Research Intern (Gordon College), 6/2018-8/2018
Yewoo Lee
Summer Research Intern (Gordon College), 6/2018-8/2018
Joshua Cochran
Summer Research Intern (Gordon College), 6/2017-8/2017
Kayla Kroning
Summer Research Intern (Gordon College), 6/2017-8/2017
Verna Caufman
Summer Research Intern (Gordon College), 6/2016-9/2016
Evelyn Braum
Summer Research Intern (Wake Forest U), 6/2016-9/2016
David Parr
Summer Research Intern (Gordon College), 6/2015-9/2015
John (Janghoon) Yoon
Summer Research Intern (Gordon College), 6/2014-8/2014
Hyunjin Song
Junior (Emory U), Laboratory research, currently a medical student at medical college of Georgia, 2013-2014
Dongwon Kim
Junior/Senior (Emory U), Laboratory research, Independent study (highest honor) 2010-2012
Funded Projects and Publications
View Dr. Knechtle's funded projects and publications on his Duke Surgery profile.
View Dr. Kwun's funded projects and publications on his Duke Surgery profile.
Lab Activities
Judges: Drs. Hartwig, Jackson, Kirk, Kwun, and Luo
Winner: Isaac Alderete (Duke DEVOL Lab)
Contact
Transplant Immune Regulation & Tolerance Lab (TIRTL) at Duke University
Jean Kwun, DMV, PhD
404-775-7406
jean.kwun@duke.edu
207 Research Dr, Jones 365
Duke University, NC 27710