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Zachary Conrad Hartman, PhD

Assistant Professor of Surgery
Assistant Professor in Pathology
Office: Research Drive, Msrbi Rm 414, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

My research interests encompass studies of immunity and inflammation in the context of developing and established cancers. These research interests involve studies of inflammation in the genesis and maintenance of specific cancer types (principally breast and ovarian), as well as the impact of inflammation on tumor metastasis and the tumor microenvironment.  My group is also involved in strategies to modulate the immune response to tumors, which involves the use of novel immunotherapeutic strategies and development of vaccines to specific oncogenic targets.  The major focus of my lab is in uncovering strategies to modulate tumor-derived inflammation and tumor-specific immunity that will translate into clinically efficacious therapies in patients.

Education and Training

  • Post Doctoral Fellow, Md Anderson Cancer Center, University of Texas Medical School at Houston, 2010 - 2012
  • Post-Doctoral Fellow, Duke University, 2006 - 2010
  • Ph.D., Duke University, 2006

Publications

Tsao, Li-Chung, Erika J. Crosby, Timothy N. Trotter, Pankaj Agarwal, Bin-Jin Hwang, Chaitanya Acharya, Casey W. Shuptrine, et al. “CD47 blockade augmentation of Trastuzumab antitumor efficacy dependent upon antibody-dependent-cellular-phagocytosis..” Jci Insight, November 5, 2019. https://doi.org/10.1172/jci.insight.131882.

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Kula, Tomasz, Mohammad H. Dezfulian, Charlotte I. Wang, Nouran S. Abdelfattah, Zachary C. Hartman, Kai W. Wucherpfennig, Herbert Kim Lyerly, and Stephen J. Elledge. “T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes..” Cell 178, no. 4 (August 8, 2019): 1016-1028.e13. https://doi.org/10.1016/j.cell.2019.07.009.

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Crosby, Erika J., William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, et al. “Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study..” Clin Cancer Res 25, no. 9 (May 1, 2019): 2725–36. https://doi.org/10.1158/1078-0432.CCR-18-3102.

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Crosby, E. J., W. R. Gwin, S. Chang, H. T. Maecker, V. Lubkov, J. C. Snyder, G. Broadwater, et al. “Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients.” In Poster Session Abstracts. American Association for Cancer Research, 2019. https://doi.org/10.1158/1538-7445.sabcs18-p2-09-16.

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Crosby, Erika J., Gangjun Lei, Junping Wei, Xiao Yi Yang, Tao Wang, Cong-Xiao Liu, H Kim Lyerly, and Zachary C. Hartman. “Abstract A22: Augmentation of a novel adenoviral vaccine strategy by checkpoint inhibitors.” In Checkpoints and Immunomodulation. American Association for Cancer Research, 2018. https://doi.org/10.1158/2326-6074.tumimm17-a22.

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Osada, Takuya, Zachary C. Hartman, Junping Wei, Gangjun Lei, Amy C. Hobeika, William R. Gwin, Marcio A. Diniz, et al. “Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers..” Breast Cancer Res 20, no. 1 (August 9, 2018). https://doi.org/10.1186/s13058-018-1023-x.

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Crosby, Erika J., Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang, Cong-Xiao Liu, Pankaj Agarwal, et al. “Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors..” Oncoimmunology 7, no. 5 (2018). https://doi.org/10.1080/2162402X.2017.1421891.

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Osada, Takuya, Kensuke Kaneko, William R. Gwin, Michael A. Morse, Amy Hobeika, Brian W. Pogue, Zachary C. Hartman, Philip F. Hughes, Timothy Haystead, and H Kim Lyerly. “In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior..” Clin Cancer Res 23, no. 24 (December 15, 2017): 7531–42. https://doi.org/10.1158/1078-0432.CCR-17-1453.

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Shuptrine, Casey W., Reham Ajina, Elana J. Fertig, Sandra A. Jablonski, H. Kim Lyerly, Zachary C. Hartman, and Louis M. Weiner. “An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection..” Cancer Immunol Immunother 66, no. 12 (December 2017): 1529–44. https://doi.org/10.1007/s00262-017-2047-2.

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