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Roger Keith Reeves, PhD

Professor in Surgery
Professor of Pathology

Formerly of Harvard Medical School and Beth Israel Deaconess Medical Center, Dr. R. Keith Reeves is currently tenured Professor of Surgery at Duke University, as well as Director of the Division of Innate and Comparative Immunology and Head of Innovation Partnerships in the Center for Human Systems Immunology. He is also currently the Director of the Duke CFAR Developmental Core and Editor-in-Chief of AIDS Research and Human Retroviruses. Over his academic career he has published extensively in the field of NK cell biology, providing some of the most comprehensive analyses of NK cells and innate lymphoid cells, including the first characterization of memory NK cells in any primate species.  Dr. Reeves’ research has been supported by NIH for over a decade by individual and consortia grants, and in addition to independent work, he collaborates as part of the HIV Vaccine Trials Network (HVTN) and the BEAT-HIV Martin Delaney HIV Cure Collaboratory.   Dr. Reeves has also served on multiple standing NIH study sections (HIV Immunopathogenesis and Vaccine Development), as well as on standing and ad hoc grant review committees for amfAR, the United States-Israel Binational Science Foundation, the UK Medical Research Council and California Institute of Regenerative Medicine, among others.   Considered a global expert in NK cell biology, Dr. Reeves’ group continues to focus on cutting edge approaches to harness NK cells in the context of vaccines and antiviral therapeutics for HIV, CMV, HCV, influenza and SARSCoV2.

Education and Training

  • Ph.D., University of Alabama Birmingham, 2007
  • B.S., Mississippi State University, 2002

Publications

Huot, Nicolas, Cyril Planchais, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, Marie Lazzerini, Pierre Rosenbaum, et al. “Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection.,” April 25, 2022. https://doi.org/10.21203/rs.3.rs-1561222/v1.

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Kroll, Kyle, Spandan Shah, Olivier Lucar, Thomas Premeaux, Cecilia Shikuma, Michael Corley, Matthew Mosher, Scott Bowler, Lishomwa Ndhlovu, and Keith Reeves. “Disruption of natural killer cell homing as a biomarker in persons aging with or without HIV.” BioRxiv, January 6, 2022. https://doi.org/10.1101/2022.01.05.475089.

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Jones, Rhianna, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan V. Shah, Scott Smith, Valerie Varner, and R Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection.” Immunology 164, no. 2 (October 2021): 348–57. https://doi.org/10.1111/imm.13376.

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Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, et al. “Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.” Sci Rep 11, no. 1 (July 15, 2021): 14507. https://doi.org/10.1038/s41598-021-93918-x.

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Jones, Rhianna, Cordelia Manickam, Daniel Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan Shah, Scott Smith, Valerie Varner, and Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection,” March 20, 2021. https://doi.org/10.1101/2021.03.19.436235.

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Huot, Nicolas, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, et al. “SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.” Nat Commun 12, no. 1 (February 24, 2021): 1282. https://doi.org/10.1038/s41467-021-21402-1.

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Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan Shah, et al. “Probiotic Supplementation Reduces Inflammatory Profiles But Does Not Prevent Oral Immune Perturbations During SIV Infection,” December 18, 2020. https://doi.org/10.1101/2020.12.17.423321.

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Manickam, Cordelia, Sho Sugawara, and R Keith Reeves. “Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020.” Plos Pathog 16, no. 8 (August 2020): e1008820. https://doi.org/10.1371/journal.ppat.1008820.

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