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Robin Elizabeth Bachelder, PhD

Associate Professor in Surgery
Associate Professor in Pathology
Division: 
Plastic, Maxillofacial, and Oral Surgery
Program: 
Integrated Plastic and Reconstructive Surgery Residency Program
Office: LSRC B217, Durham, NC 27710
Campus Mail: DUMC LSRC B217, 308 Research Drive, Durham, NC 27710

The long term goal of our laboratory is to identify novel therapeutic targets for triple-negative breast cancer (TNBC), which lacks estrogen receptor, progesterone receptor, and HER2. To reach this goal, we are studying: 1)  molecular determinants of TNBC therapy resistance, and 2) contributions of adipose stem cells to TNBC initiation/ progression.

Education and Training

  • Instructor in Medicine, Medicine, Harvard University , 1997 - 2005
  • Research Fellow, Pediatric Oncology, Harvard University , 1996 - 1997
  • Research Fellow, Medicine, Harvard University , 1995 - 1996
  • Ph.D., Harvard University , 1995

Selected Grants

Publications

Lyes, Matthew A., Sturgis Payne, Paul Ferrell, Salvatore V. Pizzo, Scott T. Hollenbeck, and Robin E. Bachelder. “Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.” Breast Cancer Res Treat 174, no. 2 (April 2019): 413–22. https://doi.org/10.1007/s10549-018-05103-w.

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Zhao, Ruya, Rayan Kaakati, Xinjian Liu, Lingfan Xu, Andrew K. Lee, Robin Bachelder, Chuan-Yuan Li, and Scott T. Hollenbeck. “CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression.” Plast Reconstr Surg 143, no. 3 (March 2019): 747–56. https://doi.org/10.1097/PRS.0000000000005316.

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Nelson, Erik R., Shenduo Li, Margaret Kennedy, Sturgis Payne, Kelly Kilibarda, Jeffrey Groth, Michelle Bowie, et al. “Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.” Oncotarget 7, no. 51 (December 20, 2016): 84030–42. https://doi.org/10.18632/oncotarget.12767.

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Li, Shenduo, Sturgis Payne, Fang Wang, Peter Claus, Zuowei Su, Jeffrey Groth, Joseph Geradts, et al. “Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance.” Breast Cancer Res 17 (July 4, 2015): 91. https://doi.org/10.1186/s13058-015-0590-3.

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Mo, Lihong, Robin E. Bachelder, Margaret Kennedy, Po-Han Chen, Jen-Tsan Chi, Andrew Berchuck, George Cianciolo, and Salvatore V. Pizzo. “Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78.” Mol Cancer Ther 14, no. 3 (March 2015): 747–56. https://doi.org/10.1158/1535-7163.MCT-14-0579.

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Mo, Lihong, Vendula Pospichalova, Zhiqing Huang, Susan K. Murphy, Sturgis Payne, Fang Wang, Margaret Kennedy, et al. “Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.” Plos One 10, no. 7 (2015): e0131579. https://doi.org/10.1371/journal.pone.0131579.

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Li, S., S. Payne, F. Wang, P. Claus, Z. Su, J. Groth, J. Geradts, et al. “Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance.” Breast Cancer Research, 2015. https://doi.org/10.1186/s13058-015-0590-3.

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Li, Shenduo, Margaret Kennedy, Sturgis Payne, Kelly Kennedy, Victoria L. Seewaldt, Salvatore V. Pizzo, and Robin E. Bachelder. “Model of tumor dormancy/recurrence after short-term chemotherapy.” Plos One 9, no. 5 (2014): e98021. https://doi.org/10.1371/journal.pone.0098021.

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Geradts, J., A. G. De Herreros, Z. Su, J. Burchette, G. Broadwater, and R. E. Bachelder. “Erratum:Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas (Human Pathology (2011) 42 (1125-1131)).” Human Pathology 43, no. 10 (October 1, 2012): 1787. https://doi.org/10.1016/j.humpath.2012.07.001.

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