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Robin Elizabeth Bachelder, PhD

Associate Professor in Surgery
Associate Professor in Pathology
Division: 
Plastic, Maxillofacial, and Oral Surgery
Office: LSRC B217, Durham, NC 27710
Campus Mail: DUMC LSRC B217, 308 Research Drive, Durham, NC 27710

The long term goal of our laboratory is to identify novel therapeutic targets for triple-negative breast cancer (TNBC), which lacks estrogen receptor, progesterone receptor, and HER2. To reach this goal, we are studying: 1)  molecular determinants of TNBC therapy resistance, and 2) contributions of adipose stem cells to TNBC initiation/ progression.

Education and Training

  • Instructor in Medicine, Medicine, Harvard University , 1997 - 2005
  • Research Fellow, Pediatric Oncology, Harvard University , 1996 - 1997
  • Research Fellow, Medicine, Harvard University , 1995 - 1996
  • Ph.D., Harvard University , 1995

Selected Grants

Publications

Lyes, MA, Payne, S, Ferrell, P, Pizzo, SV, Hollenbeck, ST, and Bachelder, RE. "Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence." Breast Cancer Research and Treatment (December 29, 2018).

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Bachelder, RE. "Cell Surface GRP78: A Targetable Marker of Cancer Stem-Like Cells." In Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 99-109. March 22, 2018.

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Nelson, ER, Li, S, Kennedy, M, Payne, S, Kilibarda, K, Groth, J, Bowie, M, Parilla-Castellar, E, de Ridder, G, Marcom, PK, Lyes, M, Peterson, BL, Cook, M, Pizzo, SV, McDonnell, DP, and Bachelder, RE. "Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface." Oncotarget 7, no. 51 (December 2016): 84030-84042.

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Li, S, Payne, S, Wang, F, Claus, P, Su, Z, Groth, J, Geradts, J, de Ridder, G, Alvarez, R, Marcom, PK, Pizzo, SV, and Bachelder, RE. "Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance." Breast cancer research : BCR 17 (July 4, 2015): 91-.

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Mo, L, Bachelder, RE, Kennedy, M, Chen, P-H, Chi, J-T, Berchuck, A, Cianciolo, G, and Pizzo, SV. "Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78." Molecular Cancer Therapeutics 14, no. 3 (March 2015): 747-756.

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Mo, L, Pospichalova, V, Huang, Z, Murphy, SK, Payne, S, Wang, F, Kennedy, M, Cianciolo, GJ, Bryja, V, Pizzo, SV, and Bachelder, RE. "Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells." Plos One 10, no. 7 (January 2015): e0131579-null.

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Li, S, Payne, S, Wang, F, Claus, P, Su, Z, Groth, J, Geradts, J, Ridder, GD, Alvarez, R, Marcom, PK, Pizzo, SV, and Bachelder, RE. "Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance." Breast Cancer Research (2015).

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Li, S, Kennedy, M, Payne, S, Kennedy, K, Seewaldt, VL, Pizzo, SV, and Bachelder, RE. "Model of tumor dormancy/recurrence after short-term chemotherapy." PloS one 9, no. 5 (January 2014): e98021-.

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Geradts, J, De Herreros, AG, Su, Z, Burchette, J, Broadwater, G, and Bachelder, RE. "Erratum:Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas (Human Pathology (2011) 42 (1125-1131))." Human Pathology 43, no. 10 (October 1, 2012): 1787-null.

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D'Amato, NC, Ostrander, JH, Bowie, ML, Sistrunk, C, Borowsky, A, Cardiff, RD, Bell, K, Young, LJT, Simin, K, Bachelder, RE, Delrow, J, Dawson, A, Yee, LD, Mrózek, K, Clay, TM, Osada, T, and Seewaldt, VL. "Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system." PLoS One 7, no. 9 (2012): e45684-.

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