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Ralph Randal Bollinger, MD, MS, PhD, MBA

2016 Master Surgeon
Professor Emeritus of Surgery
Office: 113A Bell Bldg, Durham, NC 27710
Campus Mail: DUMC Box 2910 Med Ctr, Durham, NC 27710

CURRENT RESEARCH EFFORT

The current research effort of the D.B. Amos Transplant Research Laboratory is focused on xenotransplantation and the clinical trials of monoclonal antibody for the treatment of rejection in human renal allograft recipients. A primary accomplishment in 1998 was completion of the fifth successful year of an NIH funded Program Project in Xenotransplantation. Significant accomplishments included prolongation of porcine to baboon cardiac xenografts with transgenic pig hearts expressing human CD59 and DAF or MCP complement regulatory proteins, and the continuation of ex vivo xenograft perfusion of porcine livers by human liver failure patients as a bridge to hepatic transplantation. Studies of the human-antiporcine cellular repertoire made progress. Clinical outcome studies of ileoanal pull through in inflammatory bowel disease patients confirmed excellent function and patient satisfaction. The creation of a Duke Comprehensive Transplant Center continued with the work of organ specific task forces,the opening of a multidisciplinary transplant clinic and the establishment of a Transplant Clinical Business Unit.

Education and Training

  • M.B.A., Duke University, 1997
  • Ph.D., Duke University, 1977
  • M.S., Tulane University, 1970
  • M.D., Tulane University, 1970
  • B.S., Tulane University, 1966

Publications

Villeneuve, C, Kou, HH, Eckermann, H, Palkar, A, Anderson, LG, McKenney, EA, Bollinger, RR, and Parker, W. "Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?." Microbes and Infection 20, no. 3 (March 2018): 147-155. (Review)

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Sanders, NL, Bollinger, RR, Lee, R, Thomas, S, and Parker, W. "Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology." World J Gastroenterol 19, no. 34 (September 14, 2013): 5607-5614. (Review)

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Lee, Y-H, Su, K-Y, Wyse, A, Barbas, A, Palestrandt, D, Shieh, K, Everett, ML, Devalapalli, A, Orndorff, PE, Bollinger, RR, and Parker, W. "Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin." Microbiol Immunol 55, no. 3 (March 2011): 174-183.

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Lee, SM, Wyse, A, Lesher, A, Everett, ML, Lou, L, Holzknecht, ZE, Whitesides, JF, Spears, PA, Bowles, DE, Lin, SS, Tonkonogy, SL, Orndorff, PE, Bollinger, RR, and Parker, W. "Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days." Applied and Environmental Microbiology 76, no. 14 (July 2010): 4655-4663.

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Barbas, AS, Lesher, AP, Thomas, AD, Wyse, A, Devalapalli, AP, Lee, Y-H, Tan, H-E, Orndorff, PE, Bollinger, RR, and Parker, W. "Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel." Exp Biol Med (Maywood) 234, no. 10 (October 2009): 1174-1185.

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Norton, JA, Barie, PS, Bollinger, RR, Chang, AE, Lowry, SF, Mulvihill, SJ, Pass, HI, and Thompson, RW. Preface. December 1, 2008.

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Norton, JA, Barie, PS, Bollinger, RR, Chang, AE, Lowry, SF, Mulvihill, SJ, Pass, HI, and Thompson, RW. Surgery: Basic science and clinical evidence: Second edition. December 1, 2008.

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Bollinger, RR, and Knechtle, SJ. "Vascular access for dialysis, chemotherapy, and nutritional support." In Surgery: Basic Science and Clinical Evidence: Second Edition, 1457-1468. December 1, 2008.

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Downing, TE, Sporn, TA, Bollinger, RR, Davis, RD, Parker, W, and Lin, SS. "Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity." Exp Biol Med (Maywood) 233, no. 10 (October 2008): 1202-1212.

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Bollinger, RR, Barbas, AS, Bush, EL, Lin, SS, and Parker, W. "Biofilms in the normal human large bowel: fact rather than fiction." Gut 56, no. 10 (October 2007): 1481-1482. (Letter)

Scholars@Duke

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