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Ralph Randal Bollinger, MD, MS, PhD, MBA

2016 Master Surgeon
Professor Emeritus of Surgery
Office: 113A Bell Bldg, Durham, NC 27710
Campus Mail: DUMC Box 2910 Med Ctr, Durham, NC 27710


The current research effort of the D.B. Amos Transplant Research Laboratory is focused on xenotransplantation and the clinical trials of monoclonal antibody for the treatment of rejection in human renal allograft recipients. A primary accomplishment in 1998 was completion of the fifth successful year of an NIH funded Program Project in Xenotransplantation. Significant accomplishments included prolongation of porcine to baboon cardiac xenografts with transgenic pig hearts expressing human CD59 and DAF or MCP complement regulatory proteins, and the continuation of ex vivo xenograft perfusion of porcine livers by human liver failure patients as a bridge to hepatic transplantation. Studies of the human-antiporcine cellular repertoire made progress. Clinical outcome studies of ileoanal pull through in inflammatory bowel disease patients confirmed excellent function and patient satisfaction. The creation of a Duke Comprehensive Transplant Center continued with the work of organ specific task forces,the opening of a multidisciplinary transplant clinic and the establishment of a Transplant Clinical Business Unit.

Education and Training

  • M.B.A., Duke University, 1997
  • Ph.D., Duke University, 1977
  • M.S., Tulane University, 1970
  • M.D., Tulane University, 1970
  • B.S., Tulane University, 1966


Villeneuve, Chantal, Henry H. Kou, Henrik Eckermann, Antara Palkar, Lauren G. Anderson, Erin A. McKenney, R Randal Bollinger, and William Parker. “Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?” Microbes Infect 20, no. 3 (March 2018): 147–55.

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Sanders, Nathan L., R Randal Bollinger, Ryan Lee, Steven Thomas, and William Parker. “Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology.” World J Gastroenterol 19, no. 34 (September 14, 2013): 5607–14.

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Lee, Yu-Huei, Kuei-Ying Su, Aaron Wyse, Andrew Barbas, Daniel Palestrandt, Karl Shieh, Mary Lou Everett, et al. “Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin.” Microbiol Immunol 55, no. 3 (March 2011): 174–83.

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Lee, Sean M., Aaron Wyse, Aaron Lesher, Mary Lou Everett, Linda Lou, Zoie E. Holzknecht, John F. Whitesides, et al. “Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.” Appl Environ Microbiol 76, no. 14 (July 2010): 4655–63.

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Barbas, Andrew S., Aaron P. Lesher, Anitra D. Thomas, Aaron Wyse, Aditya P. Devalapalli, Yu-Huei Lee, Hung-Enn Tan, Paul E. Orndorff, R Randal Bollinger, and William Parker. “Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel.” Exp Biol Med (Maywood) 234, no. 10 (October 2009): 1174–85.

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Downing, Tacy E., Thomas A. Sporn, R Randal Bollinger, R Duane Davis, William Parker, and Shu S. Lin. “Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.” Exp Biol Med (Maywood) 233, no. 10 (October 2008): 1202–12.

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Bollinger, R Randal, Andrew S. Barbas, Errol L. Bush, Shu S. Lin, and William Parker. “Biofilms in the normal human large bowel: fact rather than fiction.” Gut, October 2007.