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Joshua Clair Snyder, PhD

Assistant Professor of Surgery
Assistant Professor of Cell Biology
Office: Msrbi Rm 475A, Durham, NC 27710
Campus Mail: DUMC Box 3287 Med Ctr, Durham, NC 27710

I am the PI of the Cancer Initiation and Cancer Cell Behavior lab. Our research objective is to determine how cancer cells adapt and grow before cancer is diagnosed. Our lab is also part of the Center for Applied therapeutics where we share our models as tools for preclinical and translational research. To learn more about our research please visit the Cancer Initiation and Cancer Cell Behavior Lab's homepage.

Education and Training

  • Ph.D., University of Pittsburgh, School of Medicine, 2009

Publications

Osada, Takuya, Erika J. Crosby, Kensuke Kaneko, Joshua C. Snyder, Joshua D. Ginzel, Chaitanya R. Acharya, Xiao-Yi Yang, et al. “HSP90-specific nIR probe identifies aggressive prostate cancers: translation from preclinical models to a human phase I study.” Mol Cancer Ther, October 21, 2021. https://doi.org/10.1158/1535-7163.MCT-21-0334.

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Ginzel, Joshua D., Chaitanya R. Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G. Boone, Lauren K. Rochelle, Wendy L. Roberts, et al. “HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase.” Mol Cancer Res 19, no. 10 (October 2021): 1699–1711. https://doi.org/10.1158/1541-7786.MCR-21-0215.

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Ginzel, Joshua D., Chaitanya R. Acharya, Ping Wang, Alexis Schmid, Peter G. Boone, Lauren K. Rochelle, Wendy Roberts, et al. “Visualizing Cell Competition and Mechanisms of Occult Tumorigenesis Ex Vivo.” In In Vitro Cellular & Developmental Biology Animal, 57:S10–S10, 2021.

Scholars@Duke

Smith, Jeffrey S., Thomas F. Pack, Asuka Inoue, Claudia Lee, Kevin Zheng, Issac Choi, Dylan S. Eiger, et al. “Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors.” Science 371, no. 6534 (March 12, 2021). https://doi.org/10.1126/science.aay1833.

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Hsieh, Michael, Hidetoshi Mori, Jasmine Rosa, Hyeongsun Moon, Louis Schuetter, Qian Chen, Joshua Snyder, and Alexander Borowsky. “Dual Detection of Extracellular and Intracellular Domains of HER2/ERBB2 Reveals Distinct Patterns of Isoform Expression with Mechanistic and Therapeutic Implications.” In Modern Pathology, 34:113–14, 2021.

Scholars@Duke

Hsieh, Michael, Hidetoshi Mori, Jasmine Rosa, Hyeongsun Moon, Louis Schuetter, Qian Chen, Joshua Snyder, and Alexander Borowsky. “Dual Detection of Extracellular and Intracellular Domains of HER2/ERBB2 Reveals Distinct Patterns of Isoform Expression with Mechanistic and Therapeutic Implications.” In Laboratory Investigation, 101:113–14, 2021.

Scholars@Duke

Crosby, Erika J., Chaitanya R. Acharya, Anthony-Fayez Haddad, Christopher A. Rabiola, Gangjun Lei, Jun-Ping Wei, Xiao-Yi Yang, et al. “Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer.” Clin Cancer Res 26, no. 17 (September 1, 2020): 4670–81. https://doi.org/10.1158/1078-0432.CCR-20-0389.

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Kaneko, Kensuke, Takuya Osada, Michael A. Morse, William R. Gwin, Joshua D. Ginzel, Joshua C. Snyder, Xiao-Yi Yang, et al. “Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors.” Commun Biol 3, no. 1 (May 8, 2020): 226. https://doi.org/10.1038/s42003-020-0956-7.

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Boone, Peter G., Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, et al. “A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.” Nat Commun 10, no. 1 (December 2, 2019): 5490. https://doi.org/10.1038/s41467-019-13330-y.

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