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Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Kwun, Jean, Alton B. Farris, Hyunjin Song, William T. Mahle, William J. Burlingham, and Stuart J. Knechtle. “Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.” Transplantation 99, no. 12 (December 2015): 2485–93. https://doi.org/10.1097/TP.0000000000000805.

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Burghuber, C. K., J. Kwun, E. J. Kim, F. V. Leopardi, A. C. Gibby, N. N. Iwakoshi, and S. J. Knechtle. “NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS.” In Transplant International, 28:12–12. WILEY-BLACKWELL, 2015.

Scholars@Duke

Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Burghuber, C., J. Kwun, E. Page, A. Gibby, F. Leopardi, A. Farris, N. Iwakoshi, and S. Knechtle. “Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Burghuber, C., J. Kwun, F. Leopardi, A. Gibby, A. Farris, N. Iwakoshi, and S. Knechtle. “Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Kwun, J., B. Oh, H. Song, A. Farris, A. Kirk, W. Mahle, and S. Knechtle. “LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Burghuber, C., J. Kwun, A. Gibby, N. Iwakoshi, and S. Knechtle. “MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Burghuber, C., J. Kwun, E. Page, F. Leopardi, A. Gibby, A. Farris, N. Iwakoshi, and S. Knechtle. “T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Mou, D., J. Espinosa, L. Stempora, J. Kwun, N. Iwakoshi, and A. Kirk. “Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.

Scholars@Duke

Kwun, J., E. Page, J. J. Hong, A. Gibby, J. Yoon, A. B. Farris, F. Villinger, and S. Knechtle. “Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.” Am J Transplant 15, no. 3 (March 2015): 815–22. https://doi.org/10.1111/ajt.13045.

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