Skip to main content

Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Schroder, P., B. Ezekian, F. Saccoccio, J. Yoon, M. Dennis, K. Freischlag, J. Kwun, S. Permar, and S. Knechtle. “Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates.” In American Journal of Transplantation, 18:899–900. WILEY, 2018.

Scholars@Duke

Freischlag, K., B. Ezekian, P. Schroder, J. Everitt, J. Yoon, M. Swiderska-Syn, W. Parker, A. Diehl, J. Kwun, and S. Knechtle. “Long-Term HIF-1 alpha Stabilization is Associated with Fibrosis in Rat Lung Allografts.” In American Journal of Transplantation, 18:490–91. WILEY, 2018.

Scholars@Duke

Yoon, J., B. Ezekian, M. Manook, J. Kwun, and S. Knechtle. “Rhesus Monkey Have natural Antibody toward Swine That is Not Influenced by Allosensitization nor by Carfilzomib/tocilizumab.” In American Journal of Transplantation, 18:764–764. WILEY, 2018.

Scholars@Duke

Kwun, J., B. Ezekian, M. Manook, J. Park, J. Yoon, J. Sloan-Lancaster, C. Fortier, P. Rao, and S. Knechtle. “Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation.” In American Journal of Transplantation, 18:901–901. WILEY, 2018.

Scholars@Duke

Kwun, J., E. Brian, M. Manook, J. Park, K. Freischlag, J. Yoon, J. Yi, M. Stegall, and S. Knechtle. “Targeting Plasma Cells with Anti-CD38mAb (Daratumumab) and CXCR4 Antagonist (Plerixafor) for Desensitization.” In American Journal of Transplantation, 18:890–890. WILEY, 2018.

Scholars@Duke

Kwun, J., J. Li, C. Rouse, J. Park, A. Kirk, and L. Markert. “Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation.” In American Journal of Transplantation, 18:620–620. WILEY, 2018.

Scholars@Duke

Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119.” Blood Adv 2, no. 2 (January 23, 2018): 89. https://doi.org/10.1182/bloodadvances.2017015446.

Full Text

Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.” Front Immunol 9 (2018): 2323. https://doi.org/10.3389/fimmu.2018.02323.

Full Text

Eppensteiner, John, Robert Patrick Davis, Andrew S. Barbas, Jean Kwun, and Jaewoo Lee. “Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults.” Front Immunol 9 (2018): 190. https://doi.org/10.3389/fimmu.2018.00190.

Full Text

Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.

Full Text

Pages