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Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Oh, B., R. Ruhil, O. Bulut, J. Kwun, A. Kirk, S. Knechtle, and N. Iwakoshi. “The Effects of Viral Infection on Chronic Anti-Mediated Rejection.” In American Journal of Transplantation, 13:132–132. WILEY-BLACKWELL, 2013.

Scholars@Duke

Kwun, J., B. Oh, A. Gibby, E. Page, N. Iwakoshi, and S. Knechtle. “The Role of CD4(+)CD25(+) T reg Cells on Allo-B Cell Formation and DSA Production in a Chronic Rejection Model after T Cell Depletion.” In American Journal of Transplantation, 13:459–459. WILEY-BLACKWELL, 2013.

Scholars@Duke

Kwun, J., B. C. Oh, A. C. Gibby, R. Ruhil, V. T. Lu, D. W. Kim, E. K. Page, et al. “Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.” Am J Transplant 12, no. 10 (October 2012): 2641–51. https://doi.org/10.1111/j.1600-6143.2012.04181.x.

Full Text

Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, J. B. Jenkins, E. A. Strobert, et al. “Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.” Am J Transplant 12, no. 9 (September 2012): 2395–2405. https://doi.org/10.1111/j.1600-6143.2012.04074.x.

Full Text

Ruhil, R., S. Talebagha, O. P. Bulut, B. Oh, D. Sairsingh, J. Kwun, V. T. Lu, S. Knechtle, and N. Iwakoshi. “Acute Viral Infection Mediates Allosensitization and Abrogates Humoral Tolerance.” In American Journal of Transplantation, 12:39–39. WILEY-BLACKWELL, 2012.

Scholars@Duke

Page, E. K., A. C. Gibby, J. Kwun, F. Leopardi, A. B. Adams, C. L. Courtney, J. B. Jenkins, E. Strobert, N. Iwakoshi, and S. J. Knechtle. “Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques.” In American Journal of Transplantation, 12:276–276. WILEY-BLACKWELL, 2012.

Scholars@Duke

Ruhil, R., D. Sairsingh, O. P. Bulut, S. Talebagha, B. Oh, J. Kwun, V. T. Lu, S. Knechtle, and N. N. Iwakoshi. “Chronic Viral Infection Leads to Distinct Alloreactive B Cell Development and Sustained Allosensitization.” In American Journal of Transplantation, 12:40–40. WILEY-BLACKWELL, 2012.

Scholars@Duke

Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, E. Strobert, J. B. Jenkins, et al. “Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques.” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.

Scholars@Duke

Kwun, J., B. Oh, A. Gibby, R. Ruhil, V. Lu, O. P. Bulut, M. Song, et al. “Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:278–278. WILEY-BLACKWELL, 2012.

Scholars@Duke

Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, V. Lu, D. Kim, et al. “Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:463–463. WILEY-BLACKWELL, 2012.

Scholars@Duke

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