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Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, et al. “Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.” Kidney Int 99, no. 1 (January 2021): 161–72. https://doi.org/10.1016/j.kint.2020.08.020.

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Dangi, Anil, Naveen R. Natesh, Irma Husain, Zhicheng Ji, Laura Barisoni, Jean Kwun, Xiling Shen, Edward B. Thorp, and Xunrong Luo. “Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection.” Jci Insight 5, no. 20 (October 15, 2020). https://doi.org/10.1172/jci.insight.141321.

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Dangi, Anil, Shuangjin Yu, Frances T. Lee, Melanie Burnette, Stuart Knechtle, Jean Kwun, and Xunrong Luo. “Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients.” Am J Transplant 20, no. 10 (October 2020): 2728–39. https://doi.org/10.1111/ajt.15878.

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Kwun, Jean, and Stuart Knechtle. “Pharmacological approaches to antibody-mediated rejection-Are we getting closer?” Am J Transplant 20, no. 10 (October 2020): 2637–38. https://doi.org/10.1111/ajt.16061.

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Atia, Andrew, Dimitrios Moris, MacKenzie McRae, Mingqing Song, Linda Stempora, Francis Leopardi, Kyha Williams, et al. “Th17 cell inhibition in a costimulation blockade-based regimen for vascularized composite allotransplantation using a nonhuman primate model.” Transpl Int 33, no. 10 (October 2020): 1294–1301. https://doi.org/10.1111/tri.13612.

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Schmitz, Robin, Paul M. Schroder, Zachary W. Fitch, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Alton B. Farris, et al. “BLOCKING COMPLEMENT C3 IN A SENSITIZED NONHUMAN PRIMATE MODEL OF KIDNEY TRANSPLANTATION.” In Transplantation, 104:S121–S121, 2020.

Scholars@Duke

Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Mingqing Song, Alton B. Farris, et al. “CARFILZOMIB AND LULIZUMAB-BASED DESENSITIZATION PROLONGS ALLOGRAFT SURVIVAL IN SENSITIZED NON-HUMAN PRIMATES KIDNEY TRANSPLANTATION MODEL.” In Transplantation, 104:S46–S46, 2020.

Scholars@Duke

Scheuermann, Uwe, Elisabeth R. Seyferth, Nader Abraham, Samuel J. Kesseli, Samantha E. Halpern, Minghua Zhu, Mingqing Song, et al. “Sirtuin-1 expression and activity is diminished in aged liver grafts.” Sci Rep 10, no. 1 (July 17, 2020): 11860. https://doi.org/10.1038/s41598-020-68314-6.

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Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020). https://doi.org/10.1172/jci.insight.129983.

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Kwun, Jean, and Stuart Knechtle. “Experimental modeling of desensitization: What have we learned about preventing AMR?” Am J Transplant 20 Suppl 4 (June 2020): 2–11. https://doi.org/10.1111/ajt.15873.

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