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Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Fitch, Zachary W., Lillian Kang, Jie Li, Stuart J. Knechtle, Joseph W. Turek, Allan D. Kirk, M Louise Markert, and Jean Kwun. “Introducing thymus for promoting transplantation tolerance.” J Allergy Clin Immunol, June 9, 2022. https://doi.org/10.1016/j.jaci.2022.05.006.

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Anwar, Imran J., Isabel DeLaura, Qimeng Gao, Stuart Knechtle, and Jean Kwun. “Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life sustaining NHP renal allo- and xeno-transplants by Firl and Markmann.” Am J Transplant, February 18, 2022. https://doi.org/10.1111/ajt.17007.

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Song, Shengli, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, and Garnett Kelsoe. “A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines.” Commun Biol 4, no. 1 (November 25, 2021): 1338. https://doi.org/10.1038/s42003-021-02881-w.

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Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, et al. “C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.” Nat Commun 12, no. 1 (September 15, 2021): 5456. https://doi.org/10.1038/s41467-021-25745-7.

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Jelly, Evan T., Jean Kwun, Robin Schmitz, Alton B. Farris, Zachary A. Steelman, Debra L. Sudan, Stuart J. Knechtle, and Adam Wax. “Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe.” J Biomed Opt 26, no. 9 (September 2021). https://doi.org/10.1117/1.JBO.26.9.096008.

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Olaso, Danae, Miriam Manook, Dimitrios Moris, Stuart Knechtle, and Jean Kwun. “Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient.” J Clin Med 10, no. 16 (August 18, 2021). https://doi.org/10.3390/jcm10163656.

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Kwun, J., E. David, Y. Gu, Z. Ma, M. Kuchibhatla, G. Arepally, T. J. Huang, and E. T. Chambers. “Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model.” In American Journal of Transplantation, 21:401–401, 2021.

Scholars@Duke

Kwun, J., R. Schmitz, M. Manook, Z. Fitch, D. Olaso, A. Choi, J. Yoon, Y. Bae, J. Lambris, and S. Knechtle. “Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model.” In American Journal of Transplantation, 21:476–476, 2021.

Scholars@Duke

Schmitz, R., Z. W. Fitch, M. Manook, J. Yoon, A. B. Farris, J. Kwun, and S. J. Knechtle. “Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model.” In American Journal of Transplantation, 21:521–521, 2021.

Scholars@Duke

Olaso, D., M. Manook, J. Yoon, Y. Bae, A. Barbas, A. Adams, S. Knechtle, and J. Kwun. “Impact of Allosensitization on Xenotransplantation.” In American Journal of Transplantation, 21:477–78, 2021.

Scholars@Duke

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