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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Weight: 
-20

Publications

Luo, Kan, Hua-Xin Liao, Ruijun Zhang, David Easterhoff, Kevin Wiehe, Thaddeus C. Gurley, Lawrence C. Armand, et al. “Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques..” Jci Insight 1, no. 20 (December 8, 2016). https://doi.org/10.1172/jci.insight.88522.

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Ferrari, Guido, Barton F. Haynes, Scott Koenig, Jeffrey L. Nordstrom, David M. Margolis, and Georgia D. Tomaras. “Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection..” Nat Rev Drug Discov 15, no. 12 (December 2016): 823–34. https://doi.org/10.1038/nrd.2016.173.

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Astronomo, Rena D., Sampa Santra, Lamar Ballweber-Fleming, Katharine G. Westerberg, Linh Mach, Tiffany Hensley-McBain, Laura Sutherland, et al. “Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection..” Ebiomedicine 14 (December 2016): 97–111. https://doi.org/10.1016/j.ebiom.2016.11.024.

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Gay, Cynthia L., Sarah J. Willis, Anna B. Cope, JoAnn D. Kuruc, Kara S. McGee, Joe Sebastian, Amanda M. Crooks, et al. “Fixed-dose combination emtricitabine/tenofovir/efavirenz initiated during acute HIV infection; 96-week efficacy and durability..” Aids 30, no. 18 (November 28, 2016): 2815–22. https://doi.org/10.1097/QAD.0000000000001255.

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Costa, Matthew R., Justin Pollara, Regina Whitney Edwards, Michael S. Seaman, Miroslaw K. Gorny, David C. Montefiori, Hua-Xin Liao, Guido Ferrari, Shan Lu, and Shixia Wang. “Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001..” J Virol 90, no. 22 (November 15, 2016): 10362–78. https://doi.org/10.1128/JVI.01458-16.

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Altenburg, Arwen F., Carolien E. van de Sandt, Stella E. van Trierum, Heidi L. M. De Gruyter, Peter R. W. A. van Run, Ron A. M. Fouchier, Kenny Roose, et al. “Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice..” J Virol 90, no. 22 (November 15, 2016): 10209–19. https://doi.org/10.1128/JVI.01633-16.

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Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." MOLECULAR THERAPY 24, no. 11 (November 2016): 2021-2032.

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Negri, Donatella, Maria Blasi, Celia LaBranche, Robert Parks, Harikrishnan Balachandran, Michelle Lifton, Xiaoying Shen, et al. “Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques..” Mol Ther 24, no. 11 (November 2016): 2021–32. https://doi.org/10.1038/mt.2016.123.

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Nemes, Elisa, Wendy A. Burgers, Catherine Riou, Erica Andersen-Nissen, Guido Ferrari, Clive M. Gray, and Thomas Scriba. “Teaching advanced flow cytometry in Africa: 10 years of lessons learned..” Cytometry A 89, no. 11 (November 2016): 971–74. https://doi.org/10.1002/cyto.a.23015.

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Vaccari, Monica, Shari N. Gordon, Slim Fourati, Luca Schifanella, Namal P. M. Liyanage, Mark Cameron, Brandon F. Keele, et al. “Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition..” Nat Med 22, no. 10 (October 6, 2016). https://doi.org/10.1038/nm1016-1192a.

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