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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Wang, Chu, Chunlai Jiang, Nan Gao, Kaikai Zhang, Donglai Liu, Wei Wang, Zhe Cong, et al. “Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine..” Viruses 9, no. 6 (June 2, 2017). https://doi.org/10.3390/v9060135.

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Shubin, Zhanna, Weizhong Li, Bhawna Poonia, Guido Ferrari, Celia LaBranche, David Montefiori, Xiaoping Zhu, and C David Pauza. “An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques..” Clin Vaccine Immunol 24, no. 6 (June 2017). https://doi.org/10.1128/CVI.00028-17.

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García-Arriaza, Juan, Beatriz Perdiguero, Jonathan L. Heeney, Michael S. Seaman, David C. Montefiori, Nicole L. Yates, Georgia D. Tomaras, et al. “HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates..” J Virol 91, no. 9 (May 1, 2017). https://doi.org/10.1128/JVI.02182-16.

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Zurawski, Gerard, Xiaoying Shen, Sandra Zurawski, Georgia D. Tomaras, David C. Montefiori, Mario Roederer, Guido Ferrari, et al. “Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses..” J Virol 91, no. 9 (May 1, 2017). https://doi.org/10.1128/JVI.01596-16.

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Ferrari, Guido, Justin Pollara, Georgia D. Tomaras, and Barton F. Haynes. “Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection..” J Infect Dis 215, no. suppl_3 (March 15, 2017): S152–59. https://doi.org/10.1093/infdis/jiw555.

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Chege, Gerald K., Wendy A. Burgers, Tracey L. Müller, Clive M. Gray, Enid G. Shephard, Susan W. Barnett, Guido Ferrari, David Montefiori, Carolyn Williamson, and Anna-Lise Williamson. “DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies..” Vaccine 35, no. 6 (February 7, 2017): 929–37. https://doi.org/10.1016/j.vaccine.2016.12.060.

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Easterhoff, David, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, et al. “Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial..” Plos Pathog 13, no. 2 (February 2017). https://doi.org/10.1371/journal.ppat.1006182.

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Hankins, Catherine A., Sinata Koulla-Shiro, Peter Kilmarx, Guido Ferrari, Mauro Schechter, Coumba Touré Kane, François Venter, et al. “Ending AIDS as a public health threat by 2030: Scientific Developments from the 2016 INTEREST Conference in Yaoundé, Cameroon..” Antivir Ther 22, no. 2 (2017): 179–84. https://doi.org/10.3851/IMP3165.

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Buchbinder, Susan P., Nicole A. Grunenberg, Brittany J. Sanchez, Kelly E. Seaton, Guido Ferrari, M Anthony Moody, Nicole Frahm, et al. “Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia Ankara vaccine boost in healthy HIV-1 uninfected adults..” Plos One 12, no. 7 (2017). https://doi.org/10.1371/journal.pone.0179597.

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