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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Bradley, Todd, Guido Ferrari, Barton F. Haynes, David M. Margolis, and Edward P. Browne. “Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency..” Cell Reports 25, no. 1 (October 2018): 107-117.e3. https://doi.org/10.1016/j.celrep.2018.09.020.

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Phillips, Bonnie, Genevieve Fouda, Justin Pollara, Pamela Kozlowski, Anthony Moody, Guido Ferrari, Sallie Permar, and Kristina De Parisi. “The optimization of pediatric vaccine regimens to prevent mother-to-child transmission of HIV through breast milk.” In Journal of Medical Primatology, 47:344–45. WILEY, 2018.

Scholars@Duke

Shen, Xiaoying, Zoe Moodie, Arthur McMillan, Derrick Goodman, Nicole Yates, Rachel Spreng, Nicole Grunenberg, et al. “V1V2 IgG and Antibody Fc Effector Functions in a Subtype C ALVAC-HIV and Bivalent Subtype C gp120/MF59 HIV-1 Vaccine Trial in South Africa.” In Aids Research and Human Retroviruses, 34:17–17. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Singh, Shakti, Eric G. Ramírez-Salazar, Rami Doueiri, Antonio Valentin, Margherita Rosati, Xintao Hu, Brandon F. Keele, et al. “Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques..” J Virol 92, no. 15 (August 1, 2018). https://doi.org/10.1128/JVI.00281-18.

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Naggie, Susanna, Marzena Swiderska-Syn, Steve Choi, Sam Lusk, Audrey Lan, Guido Ferrari, Wing-Kin Syn, Cynthia D. Guy, and Anna Mae Diehl. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection..” Open Forum Infect Dis 5, no. 7 (July 2018). https://doi.org/10.1093/ofid/ofy138.

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Garrido, Carolina, Maria Abad-Fernandez, Marina Tuyishime, Justin J. Pollara, Guido Ferrari, Natalia Soriano-Sarabia, and David M. Margolis. “Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo..” J Virol 92, no. 12 (June 15, 2018). https://doi.org/10.1128/JVI.00235-18.

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Saunders, Kevin O., Sampa Santra, Robert Parks, Nicole L. Yates, Laura L. Sutherland, Richard M. Scearce, Harikrishnan Balachandran, et al. “Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates..” J Virol 92, no. 8 (April 15, 2018). https://doi.org/10.1128/JVI.02035-17.

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Ferrari, Guido, Jeffrey Nordstrom, Scott Koenig, Julia Sung, David Margolis, and Barton Haynes. “A-102 Antibody binding to HIV-1 infected cells as mechanism for treatment of HIV infection.” In Jaids Journal of Acquired Immune Deficiency Syndromes, 77:33–33. Ovid Technologies (Wolters Kluwer Health), 2018. https://doi.org/10.1097/01.qai.0000532483.69631.d6.

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Pollara, Justin, Chiara Orlandi, Charles Beck, R Whitney Edwards, Yi Hu, Shuying Liu, Shixia Wang, et al. “Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay..” Cytometry A 93, no. 4 (April 2018): 436–47. https://doi.org/10.1002/cyto.a.23348.

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