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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Ferrari, G., K. King, K. Rathbun, C. A. Place, M. V. Packard, J. A. Bartlett, D. P. Bolognesi, and K. J. Weinhold. “IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp).” Clin Exp Immunol 101, no. 2 (August 1995): 239–48. https://doi.org/10.1111/j.1365-2249.1995.tb08345.x.

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FERRARI, G., C. PLACE, J. BARTLETT, D. MOODY, J. TARTAGLIA, E. PAOLETTI, and K. WEINHOLD. “ANTIGEN-SPECIFIC ACTIVATION/EXPANSION OF HUMAN ANTI-HIV CTL USING RECOMBINANT ALVAC (CANARYPOX)-BASED VECTORS.” In Journal of Cellular Biochemistry, 219–219. WILEY-LISS, 1995.

Scholars@Duke

Ferrari, G., C. A. Place, P. M. Ahearne, S. M. Nigida, L. O. Arthur, D. P. Bolognesi, and K. J. Weinhold. “Comparison of anti-HIV-1 ADCC reactivities in infected humans and chimpanzees.” J Acquir Immune Defic Syndr (1988) 7, no. 4 (April 1994): 325–31.

Scholars@Duke

WEINHOLD, K. J., K. T. RATHBUN, C. A. PLACE, G. FERRARI, and D. P. BOLOGNESI. “CYTOTOXIC T-LYMPHOCYTE REACTIVITIES AMONG HIV-1 VACCINE RECIPIENTS IN THE AIDS VACCINE EVALUATION NETWORK.” In Aids Research and Human Retroviruses, 10:S89–S89. MARY ANN LIEBERT INC PUBL, 1994.

Scholars@Duke

FERRARI, G., K. KING, M. PACKARD, J. A. BARTLETT, J. TARTAGLIA, J. TOSO, and K. J. WEINHOLD. “THE EFFECT OF INTERLEUKIN-7 ON FUNCTIONAL AND PHENOTYPIC PROPERTIES OF ANTIGEN-DRIVEN CTL.” In Journal of Cellular Biochemistry, 354–354. WILEY-LISS, 1994.

Scholars@Duke

Ferrari, G., J. Ottinger, C. Place, S. M. Nigida, L. O. Arthur, and K. J. Weinhold. “The impact of HIV-1 infection on phenotypic and functional parameters of cellular immunity in chimpanzees.” Aids Res Hum Retroviruses 9, no. 7 (July 1993): 647–56. https://doi.org/10.1089/aid.1993.9.647.

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FERRARI, G., M. V. PACKARD, J. A. BARTLETT, and K. J. WEINHOLD. “TH1 AND TH2 CD4 SUBSET RESPONSES IN HIV-1 INFECTED INDIVIDUALS AT VARIOUS STAGES OF DISEASE.” In Journal of Cellular Biochemistry, 78–78. WILEY-LISS, 1993.

Scholars@Duke

Boeri, E., A. Giri, F. Lillo, G. Ferrari, O. E. Varnier, A. Ferro, S. Sabbatani, W. C. Saxinger, and G. Franchini. “In vivo genetic variability of the human immunodeficiency virus type 2 V3 region.” J Virol 66, no. 7 (July 1992): 4546–50.

Scholars@Duke

WEINHOLD, K. J., G. FERRARI, and L. O. ARTHUR. “COMPARISON OF CELLULAR ANTIVIRAL CYTOTOXICITIES PRESENT IN HIV-1 INFECTED HUMANS AND CHIMPANZEES.” In Aids Research and Human Retroviruses, 8:938–938. MARY ANN LIEBERT INC PUBL, 1992.

Scholars@Duke

Boeri, E., A. Giri, F. Lillo, G. Ferrari, O. E. Varnier, A. Ferro, S. Sabbatani, W. C. Saxinger, and G. Franchini. “In vivo genetic variability of the human immunodeficiency virus type 2 V3 region.” Journal of Virology 66, no. 7 (1992): 4546–50. https://doi.org/10.1128/jvi.66.7.4546-4550.1992.

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