Skip to main content

Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

DREAM Trial Investigators, Rury R., Jackie Bosch, Salim Yusuf, Hertzel C. Gerstein, Janice Pogue, Patrick Sheridan, Gilles Dagenais, et al. “Effect of ramipril on the incidence of diabetes.” N Engl J Med 355, no. 15 (October 12, 2006): 1551–62. https://doi.org/10.1056/NEJMoa065061.

Full Text

Betts, Michael R., Clive M. Gray, Josephine H. Cox, and Guido Ferrari. “Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV development.” Expert Rev Vaccines 5, no. 4 (August 2006): 505–16. https://doi.org/10.1586/14760584.5.4.505.

Full Text

Mulligan, M. J., N. D. Russell, C. Celum, J. Kahn, E. Noonan, D. C. Montefiori, G. Ferrari, et al. “Excellent safety and tolerability of the human immunodeficiency virus type 1 pGA2/JS2 plasmid DNA priming vector vaccine in HIV type 1 uninfected adults.” Aids Res Hum Retroviruses 22, no. 7 (July 2006): 678–83. https://doi.org/10.1089/aid.2006.22.678.

Full Text

Lathey, Janet, Neal Oden, Scott Gregory, Josephine Cox, Guido Ferrari, Susan Zimmermann, Richard Koup, M. Patricia D’Souza, and Isaac Rodriguez-Chavez. “Sa.133. ELISpot Proficiency Testing for International Laboratories Participating in HIV Vaccine Trials.” In Clinical Immunology, 119:S152–S152. Elsevier BV, 2006. https://doi.org/10.1016/j.clim.2006.04.365.

Full Text

Goepfert, Paul A., Helen Horton, M Juliana McElrath, Sanjay Gurunathan, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, et al. “High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects.” J Infect Dis 192, no. 7 (October 1, 2005): 1249–59. https://doi.org/10.1086/432915.

Full Text

Sempowski, Gregory D., Charles B. Hicks, Joseph J. Eron, John A. Bartlett, Laura P. Hale, Guido Ferrari, Lloyd J. Edwards, Susan Fiscus, and Barton F. Haynes. “Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.” J Clin Immunol 25, no. 5 (September 2005): 462–72. https://doi.org/10.1007/s10875-005-5635-4.

Full Text

Betts, Michael R., Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, et al. “Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.” Proc Natl Acad Sci U S A 102, no. 12 (March 22, 2005): 4512–17. https://doi.org/10.1073/pnas.0408773102.

Full Text

Currier, Jeffrey R., Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. “Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians.” Aids Res Hum Retroviruses 21, no. 3 (March 2005): 239–45. https://doi.org/10.1089/aid.2005.21.239.

Full Text

Kaplan, Susan S., Guido Ferrari, Terri Wrin, Nicholas S. Hellmann, Georgia D. Tomaras, Victoria E. Gryszowka, Susan A. Fiscus, Kent J. Weinhold, and Charles B. Hicks. “Longitudinal assessment of immune response and viral characteristics in HIV-infected patients with prolonged CD4(+)/viral load discordance.” Aids Res Hum Retroviruses 21, no. 1 (January 2005): 13–16. https://doi.org/10.1089/aid.2005.21.13.

Full Text

Pages