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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Currier, Jeffrey R., Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. “Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians.” Aids Res Hum Retroviruses 21, no. 3 (March 2005): 239–45. https://doi.org/10.1089/aid.2005.21.239.

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Kaplan, Susan S., Guido Ferrari, Terri Wrin, Nicholas S. Hellmann, Georgia D. Tomaras, Victoria E. Gryszowka, Susan A. Fiscus, Kent J. Weinhold, and Charles B. Hicks. “Longitudinal assessment of immune response and viral characteristics in HIV-infected patients with prolonged CD4(+)/viral load discordance.” Aids Res Hum Retroviruses 21, no. 1 (January 2005): 13–16. https://doi.org/10.1089/aid.2005.21.13.

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Cox, Josephine H., Guido Ferrari, Spyros A. Kalams, Wlodek Lopaczynski, Neal Oden, M Patricia D’souza, and M Patricia Elispot Collaborative Study Group. “Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials.” Aids Res Hum Retroviruses 21, no. 1 (January 2005): 68–81. https://doi.org/10.1089/aid.2005.21.68.

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Ferrari, Guido, Wesley Neal, Janet Ottinger, Anizsa M. Jones, Bradley H. Edwards, Paul Goepfert, Michael R. Betts, et al. “Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele.” J Immunol 173, no. 3 (August 1, 2004): 2126–33. https://doi.org/10.4049/jimmunol.173.3.2126.

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Ferrari, Guido, Jeffrey R. Currier, Matthew E. Harris, Stella Finkelstein, Angelica de Oliveira, Debra Barkhan, Josephine H. Cox, et al. “HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.” Hum Immunol 65, no. 6 (June 2004): 648–59. https://doi.org/10.1016/j.humimm.2004.02.031.

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Cox, J. H., G. Ferrari, R. T. Bailer, and R. A. Koup. “Automating Procedures for Processing, Cryopreservation, Storage, and Manipulation of Human Peripheral Blood Mononuclear Cells.” Journal of Laboratory Automation 9, no. 1 (January 1, 2004): 16–23. https://doi.org/10.1016/S1535-5535-03-00202-8.

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Harris, Matthew E., Shlomo Maayan, Bohye Kim, Michael Zeira, Guido Ferrari, Deborah L. Birx, and Francine E. McCutchan. “A cluster of HIV type 1 subtype C sequences from Ethiopia, observed in full genome analysis, is not sustained in subgenomic regions.” Aids Res Hum Retroviruses 19, no. 12 (December 2003): 1125–33. https://doi.org/10.1089/088922203771881220.

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Sufka, Susan A., Guido Ferrari, Victoria E. Gryszowka, Terri Wrin, Susan A. Fiscus, Georgia D. Tomaras, Herman F. Staats, et al. “Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control.” J Infect Dis 187, no. 7 (April 1, 2003): 1027–37. https://doi.org/10.1086/368359.

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Sempowski, G. D., C. Hicks, L. Edwards, G. Ferrari, J. Eron, and B. F. Haynes. “Naive T cells are maintained in the periphery during acute HIV infection.” In Faseb Journal, 16:A297–A297. FEDERATION AMER SOC EXP BIOL, 2002.

Scholars@Duke

Pages