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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Goonetilleke, Nilu, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, et al. “The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.” J Exp Med 206, no. 6 (June 8, 2009): 1253–72. https://doi.org/10.1084/jem.20090365.

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Lambotte, Olivier, Guido Ferrari, Christiane Moog, Nicole L. Yates, Hua-Xin Liao, Robert J. Parks, Charles B. Hicks, et al. “Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers.” Aids 23, no. 8 (May 15, 2009): 897–906. https://doi.org/10.1097/QAD.0b013e328329f97d.

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Wood, Natasha, Tanmoy Bhattacharya, Brandon F. Keele, Elena Giorgi, Michael Liu, Brian Gaschen, Marcus Daniels, et al. “HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC.” Plos Pathog 5, no. 5 (May 2009): e1000414. https://doi.org/10.1371/journal.ppat.1000414.

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Spearman, Paul, Spyros Kalams, Marnie Elizaga, Barbara Metch, Ya-Lin Chiu, Mary Allen, Kent J. Weinhold, et al. “Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial.” Vaccine 27, no. 2 (January 7, 2009): 243–49. https://doi.org/10.1016/j.vaccine.2008.10.051.

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Cristillo, A. D., G. Ferrari, L. Hudacik, D. Thompson, B. Bowen, B. Lewis, L. Galmin, et al. “P11-21. Induction of persistent mucosal humoral and cellular responses following immunization of mice with HIV-1 envelope protein in inulin-derived adjuvants.” In Retrovirology, 6:P166–P166, 2009. https://doi.org/10.1186/1742-4690-6-S3-P166.

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Sichangi, M. W., J. Bartlett, G. Ferrari, J. Crump, A. Muisyo, J. Puleo, T. Moody, B. Haynes, and J. Shao. “Detection of Cross-Clade T- and B-Cell-Mediated Immune Responses among HIV-1 Infected Individuals in Northern Tanzania.” In Aids Research and Human Retroviruses, 24:92–92. MARY ANN LIEBERT INC, 2008.

Scholars@Duke

Ferrari, G., A. Garcia-Louzao, J. Cox, A. Sambor, P. D’Souza, C. Gray, M. Jaimes, et al. “Establishing PBMC Repository for T Cell Assays Optimization and Proficiency Testing in CTC-VIMC Laboratories.” In Aids Research and Human Retroviruses, 24:127–28. MARY ANN LIEBERT INC, 2008.

Scholars@Duke

Ferrari, G., M. Liu, C. Marking, N. Goonetilleke, M. Betts, C. Gray, B. Haynes, A. McMichael, and K. Weinhold. “Lack of Highly Poly-Functional Epitope-Specific CD8+Memory T Cell Responses during Spontaneous Control of Viremia.” In Aids Research and Human Retroviruses, 24:20–20. MARY ANN LIEBERT INC, 2008.

Scholars@Duke

Liu, M. K., G. Ferrari, J. Salazar, B. Keele, R. L. Tanner, E. Turnbull, M. Mlotshwa, et al. “T Cell Escape in Subjects with Acute HIV-1 Infection.” In Aids Research and Human Retroviruses, 24:6–7. MARY ANN LIEBERT INC, 2008.

Scholars@Duke

Gasper-Smith, Nancy, Deanna M. Crossman, John F. Whitesides, Nadia Mensali, Janet S. Ottinger, Steven G. Plonk, M Anthony Moody, et al. “Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design.” J Virol 82, no. 15 (August 2008): 7700–7710. https://doi.org/10.1128/JVI.00605-08.

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