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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Lathey, Janet, Neal Oden, Scott Gregory, Josephine Cox, Guido Ferrari, Susan Zimmermann, Richard Koup, M. Patricia D’Souza, and Isaac Rodriguez-Chavez. “Sa.133. ELISpot Proficiency Testing for International Laboratories Participating in HIV Vaccine Trials.” In Clinical Immunology, 119:S152–S152. Elsevier BV, 2006. https://doi.org/10.1016/j.clim.2006.04.365.

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Goepfert, Paul A., Helen Horton, M Juliana McElrath, Sanjay Gurunathan, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, et al. “High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects..” J Infect Dis 192, no. 7 (October 1, 2005): 1249–59. https://doi.org/10.1086/432915.

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Sempowski, Gregory D., Charles B. Hicks, Joseph J. Eron, John A. Bartlett, Laura P. Hale, Guido Ferrari, Lloyd J. Edwards, Susan Fiscus, and Barton F. Haynes. “Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function..” J Clin Immunol 25, no. 5 (September 2005): 462–72. https://doi.org/10.1007/s10875-005-5635-4.

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Betts, Michael R., Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, et al. “Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection..” Proc Natl Acad Sci U S A 102, no. 12 (March 22, 2005): 4512–17. https://doi.org/10.1073/pnas.0408773102.

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Currier, Jeffrey R., Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. “Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians..” Aids Res Hum Retroviruses 21, no. 3 (March 2005): 239–45. https://doi.org/10.1089/aid.2005.21.239.

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Kaplan, Susan S., Guido Ferrari, Terri Wrin, Nicholas S. Hellmann, Georgia D. Tomaras, Victoria E. Gryszowka, Susan A. Fiscus, Kent J. Weinhold, and Charles B. Hicks. “Longitudinal assessment of immune response and viral characteristics in HIV-infected patients with prolonged CD4(+)/viral load discordance..” Aids Res Hum Retroviruses 21, no. 1 (January 2005): 13–16. https://doi.org/10.1089/aid.2005.21.13.

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Cox, Josephine H., Guido Ferrari, Spyros A. Kalams, Wlodek Lopaczynski, Neal Oden, M Patricia D’souza, and M Patricia Elispot Collaborative Study Group. “Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials..” Aids Res Hum Retroviruses 21, no. 1 (January 2005): 68–81. https://doi.org/10.1089/aid.2005.21.68.

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Ferrari, Guido, Wesley Neal, Janet Ottinger, Anizsa M. Jones, Bradley H. Edwards, Paul Goepfert, Michael R. Betts, et al. “Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele..” J Immunol 173, no. 3 (August 1, 2004): 2126–33. https://doi.org/10.4049/jimmunol.173.3.2126.

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