Skip to main content

Guido Ferrari, MD

Professor in Surgery
Research Professor in Molecular Genetics and Microbiology
Office: 915 S. Lasalle Street, Sorf Building Room 208, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Freel, S. A., R. A. Picking, G. Ferrari, C. Ochsenbauer, J. C. Kappes, J. Kirchherr, K. J. Weinhold, et al. “Ontogeny of CD8+T Cells in Acute HIV-1 that Inhibit Autologous and Heterologous Transmitted/Founder (T/F) Viruses.” In Aids Research and Human Retroviruses, 27:A13–A13. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Pollara, J., L. Morris, N. Meguid, J. Pickeral, J. Hoxie, J. Kappes, C. Ochsenbauer, et al. “Ontogeny, Breadth, and Specificity of Circulating ADCC-Mediating Antibodies in HIV-1 Infected Individuals.” In Aids Research and Human Retroviruses, 27:A66–67. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Franchini, G., P. Pegu, M. Vaccari, S. Gordon, B. Keele, M. Doster, Y. Guan, et al. “Titered Mucosal Challenge of Rhesus Macaques with SIVmac251 Recapitulates HIV Vaccine Efficacy in Humans.” In Aids Research and Human Retroviruses, 27:A4–A4. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Fouda, Genevieve G., Nicole L. Yates, Justin Pollara, Xiaoying Shen, Glenn R. Overman, Tatenda Mahlokozera, Andrew B. Wilks, et al. “HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies.” J Virol 85, no. 18 (September 2011): 9555–67. https://doi.org/10.1128/JVI.05174-11.

Full Text

Pollara, Justin, Lydia Hart, Faraha Brewer, Joy Pickeral, Beverly Z. Packard, James A. Hoxie, Akira Komoriya, et al. “High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.” Cytometry A 79, no. 8 (August 2011): 603–12. https://doi.org/10.1002/cyto.a.21084.

Full Text

Ferrari, Guido, Justin Pollara, Daniel Kozink, Tiara Harms, Mark Drinker, Stephanie Freel, M Anthony Moody, et al. “An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.” J Virol 85, no. 14 (July 2011): 7029–36. https://doi.org/10.1128/JVI.00171-11.

Full Text

Lai, Lilin, Suefen Kwa, Pamela A. Kozlowski, David C. Montefiori, Guido Ferrari, Welkin E. Johnson, Vanessa Hirsch, et al. “Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine.” J Infect Dis 204, no. 1 (July 1, 2011): 164–73. https://doi.org/10.1093/infdis/jir199.

Full Text

Gay, Cynthia, Oliver Dibben, Jeffrey A. Anderson, Andrea Stacey, Ashley J. Mayo, Philip J. Norris, JoAnn D. Kuruc, et al. “Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy.” Plos One 6, no. 5 (May 10, 2011): e19617. https://doi.org/10.1371/journal.pone.0019617.

Full Text

Yamamoto, Takuya, David A. Price, Joseph P. Casazza, Guido Ferrari, Martha Nason, Pratip K. Chattopadhyay, Mario Roederer, et al. “Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.” Blood 117, no. 18 (May 5, 2011): 4805–15. https://doi.org/10.1182/blood-2010-11-317297.

Full Text

Frahm, Marc, Neela D. Goswami, Kouros Owzar, Emily Hecker, Ann Mosher, Emily Cadogan, Payam Nahid, Guido Ferrari, and Jason E. Stout. “Discriminating between latent and active tuberculosis with multiple biomarker responses.” Tuberculosis (Edinb) 91, no. 3 (May 2011): 250–56. https://doi.org/10.1016/j.tube.2011.02.006.

Full Text

Pages