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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Gay, Cynthia L., Ashley J. Mayo, Chelu K. Mfalila, Haitao Chu, Anna C. Barry, JoAnn D. Kuruc, Kara S. McGee, et al. “Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection.” Aids 25, no. 7 (April 24, 2011): 941–49. https://doi.org/10.1097/QAD.0b013e3283463c07.

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Ganusov, Vitaly, Nilu Goonetilleke, Michael Liu, Guido Ferrari, George Shaw, Andrew McMichael, Persephone Borrow, Bette Korber, and Alan Perelson. “Fitness costs and diversity of CTL response determine the rate of CTL escape during the acute and chronic phases of HIV infection.” Journal of Immunology 186 (April 1, 2011).

Scholars@Duke

Keefer, Michael C., Sharon E. Frey, Marnie Elizaga, Barbara Metch, Stephen C. De Rosa, Paulo F. Barroso, Georgia Tomaras, et al. “A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects.” Vaccine 29, no. 10 (February 24, 2011): 1948–58. https://doi.org/10.1016/j.vaccine.2010.12.104.

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Ferrari, Guido, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, et al. “Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.” Plos Pathog 7, no. 2 (February 10, 2011): e1001273. https://doi.org/10.1371/journal.ppat.1001273.

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Weinberg, Adriana, Lin Ye Song, Cindy L. Wilkening, Terry Fenton, John Hural, Raul Louzao, Guido Ferrari, et al. “Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays.” J Immunol Methods 363, no. 1 (December 15, 2010): 42–50. https://doi.org/10.1016/j.jim.2010.09.032.

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Pollara, J., G. Landucci, C. Trac, C. White, N. Yates, J. Kappes, C. Ochsenbauer, et al. “Early Appearance of ADCC- and ADCVI-mediating Antibody Responses Against Autologous HIV-1 Transmitted/Founder Virus.” In Aids Research and Human Retroviruses, 26:A12–A12. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Ferrari, G., B. Korber, E. Turnbull, M. K. Liu, N. Goonetilleke, J. Salazar, M. Betts, et al. “High magnitude and multifunctionality epitope-specific CD8+T-cell responses are associated are associated with selection of escape mutants in acute HIV infection.” In Aids Research and Human Retroviruses, 26:A5–6. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Pollara, J., L. Hart, J. Hoxie, J. Kappes, C. Ochsenbauer, L. Morris, K. Soderberg, et al. “High titers of cross-clade ADCC-mediating antibodies are detectable in plasma samples collected from individuals with broadly neutralizing antibodies.” In Aids Research and Human Retroviruses, 26:A20–21. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Yates, N., X. Shen, P. Liu, S. Barnett, P. Spearman, S. Lu, G. Ferrari, et al. “Vaccine-Elicited IgG Subclasses and Functional Antibodies.” In Aids Research and Human Retroviruses, 26:A157–A157. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Graham, Barney S., M Juliana McElrath, Michael C. Keefer, Kyle Rybczyk, David Berger, Kent J. Weinhold, Janet Ottinger, et al. “Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.” Plos One 5, no. 8 (August 10, 2010): e11995. https://doi.org/10.1371/journal.pone.0011995.

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