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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Yates, N., X. Shen, P. Liu, S. Barnett, P. Spearman, S. Lu, G. Ferrari, et al. “Vaccine-Elicited IgG Subclasses and Functional Antibodies.” In Aids Research and Human Retroviruses, 26:A157–A157. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Graham, Barney S., M Juliana McElrath, Michael C. Keefer, Kyle Rybczyk, David Berger, Kent J. Weinhold, Janet Ottinger, et al. “Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.” Plos One 5, no. 8 (August 10, 2010): e11995. https://doi.org/10.1371/journal.pone.0011995.

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Freel, Stephanie A., Laurie Lamoreaux, Pratip K. Chattopadhyay, Kevin Saunders, David Zarkowsky, R Glenn Overman, Christina Ochsenbauer, et al. “Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination.” J Virol 84, no. 10 (May 2010): 4998–5006. https://doi.org/10.1128/JVI.00138-10.

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Cella, Marina, Rachel Presti, William Vermi, Kerry Lavender, Emma Turnbull, Christina Ochsenbauer-Jambor, John C. Kappes, et al. “Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.” Eur J Immunol 40, no. 4 (April 2010): 949–54. https://doi.org/10.1002/eji.200940234.

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Janetzki, Sylvia, L. Price, C. M. Britten, S. H. van der Burg, J. Caterini, J. R. Currier, G. Ferrari, et al. “Performance of serum-supplemented and serum-free media in IFNgamma Elispot Assays for human T cells.” Cancer Immunol Immunother 59, no. 4 (April 2010): 609–18. https://doi.org/10.1007/s00262-009-0788-2.

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Makedonas, George, Natalie Hutnick, Danielle Haney, Alexandra C. Amick, Jay Gardner, Gabriela Cosma, Adam R. Hersperger, et al. “Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.” Plos Pathog 6, no. 3 (March 5, 2010): e1000798. https://doi.org/10.1371/journal.ppat.1000798.

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Goonetilleke, Nilu, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, et al. “The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.” J Exp Med 206, no. 6 (June 8, 2009): 1253–72. https://doi.org/10.1084/jem.20090365.

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Lambotte, Olivier, Guido Ferrari, Christiane Moog, Nicole L. Yates, Hua-Xin Liao, Robert J. Parks, Charles B. Hicks, et al. “Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers.” Aids 23, no. 8 (May 15, 2009): 897–906. https://doi.org/10.1097/QAD.0b013e328329f97d.

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Wood, Natasha, Tanmoy Bhattacharya, Brandon F. Keele, Elena Giorgi, Michael Liu, Brian Gaschen, Marcus Daniels, et al. “HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC.” Plos Pathog 5, no. 5 (May 2009): e1000414. https://doi.org/10.1371/journal.ppat.1000414.

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Cristillo, A. D., G. Ferrari, L. Hudacik, D. Thompson, B. Bowen, B. Lewis, L. Galmin, et al. “P11-21. Induction of persistent mucosal humoral and cellular responses following immunization of mice with HIV-1 envelope protein in inulin-derived adjuvants.” In Retrovirology, 6:P166–P166, 2009. https://doi.org/10.1186/1742-4690-6-S3-P166.

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