Skip to main content

Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Himes, Jonathon E., Ria Goswami, Riley J. Mangan, Amit Kumar, Thomas L. Jeffries, Joshua A. Eudailey, Holly Heimsath, et al. “Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys..” Mucosal Immunol 11, no. 6 (November 2018): 1716–26. https://doi.org/10.1038/s41385-018-0067-7.

Full Text

Phillips, Bonnie, Koen K. A. Van Rompay, Jennifer Rodriguez-Nieves, Clarisse Lorin, Marguerite Koutsoukos, Mark Tomai, Christopher B. Fox, et al. “Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques..” J Virol 92, no. 20 (October 15, 2018). https://doi.org/10.1128/JVI.01051-18.

Full Text

Bradley, Todd, Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W. Cain, Ricardo Henao, Vaishnavi Venkat, et al. “RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses..” Cell 175, no. 2 (October 4, 2018): 387-399.e17. https://doi.org/10.1016/j.cell.2018.08.064.

Full Text

Pollara, Justin, Dorothy I. Jones, Tori Huffman, Maria Dennis, Grace Li, Derrick Goodman, R Whitney Edwards, et al. “Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models.” In Aids Research and Human Retroviruses, 34:129–129. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Wang, Shixia, Justin Pollara, Sherry Stanfield-Oakley, Diego Farfan-Arribas, Shuying Liu, Guido Ferrari, and Shan Lu. “Cross-clade ADCC Activities in Human Volunteer Sera Elicited by a Polyvalent DNA Prime-protein Boost HIV Vaccine DP6-001.” In Aids Research and Human Retroviruses, 34:129–129. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Williams, LaTonya, Matthew Zirui Tay, Xiaoying Shen, Sheetal Sawant, Lindsay Dahora, Nicole Yates, David Easterhoff, et al. “Delayed and Repetitive Boosting of RV144 Vaccinees Improves Antiviral Immunity Associated With Correlates of HIV-1 Infection Risk.” In Aids Research and Human Retroviruses, 34:88–88. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Felber, Barbara, Shakti Singh, Antonio Valentin, Margherita Rosati, Eric Ramierz, Rami Doueiri, Xintao Hu, et al. “DNA and protein co-delivery vaccines using TLR-4-based adjuvants induce potent immune responses able to delay heterologous SIV acquisition.” In Journal of Medical Primatology, 47:313–313. WILEY, 2018.

Scholars@Duke

Msafiri, Frank, Agricola Joachim, Raquel Matavele Chissumba, Christof Geldmacher, Said Aboud, Wolfgang Stohr, Edna Viegas, et al. “Frequent Anti-V1V2 Responses Induced by HIV-DNA Followed by HIV-MVA With or Without CN54rgp140/GLA-AF in Healthy Tanzanian and Mozambican Volunteers.” In Aids Research and Human Retroviruses, 34:119–20. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Mielke, Dieter, Rutendo Ziki, Colin Anthony, Christina Ochsenbauer, Nigel Garrett, Salim S Abdool Karim, David Montefiori, et al. “Neutralizing and ADCC Activity of Anti-HIV-1 Antibodies Against Acute Subtype C Envs: Implications for Prevention and Treatment of HIV-1 Infection.” In Aids Research and Human Retroviruses, 34:53–53. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Tuyishime, Marina, Carolina Garrido, Shalini Jha, Anthony DeVico, Barton Haynes, David Margolis, and Guido Ferrari. “Recognition and Elimination of HIV-1-infected Cells by ADCC-mediating mAbs for Prevention and Treatment of HIV-1 Infection.” In Aids Research and Human Retroviruses, 34:126–126. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Pages